The outcomes of a low-cost, non-valved glaucoma drainage device using mitomycin-C: 1-year results

Abstract

Purpose To evaluate the indications, outcomes, and complications of the usage of Aurolab Aqueous Drainage Implant (AADI) using mitomycin-C. Methods A retrospective case series of patients who underwent AADI placement using mitomycin-C between April 2018 and June 2020 at Ain Shams University Hospitals, Cairo, Egypt. The data was extracted from the records of the patients with a minimum of 1 year of follow-up. Complete success was defined as IOP ≥ 5 mmHg and ≤ 21 mmHg or reduction of IOP by ≥ 20% from baseline without antiglaucoma medications (AGMs). Qualified success was defined as reaching the same IOP range with the aid of AGM. Results A total of 50 eyes of 48 patients were included. Neovascular glaucoma represented the commonest indication (13 patients, 26%). The mean preoperative IOP was 34.0 ± 7.1 mmHg, with a median number of AGM of 3 (mean ± SD = 2.84 ± 1), while the mean IOP after 12 months was 14.3 ± 4 with a median number of AGM of 0. (mean ± SD = 0.52 ± 0.89) (p < 0.001). Complete success was achieved in 33 patients (66%). Qualified success was achieved in 14 patients (28%). Thirteen eyes (26%) had variable postoperative complications; none of them required explantation of the device or affected the visual acuity (except one patient). Conclusion AADI with using mitomycin-C and ripcord during the surgery is an effective and relatively safe method of control of IOP in refractory and advanced cases of glaucoma, with an overall success rate of 94%.

Treatment of Pediatric Glaucoma

“…53 The Paul glaucoma implant (Advanced Ophthalmic Innovations, Singapore, Republic of Singapore) is a newer medical-grade silicone implant designed with a smaller tube diameter (0.127-mm internal diameter and 0.467-mm external diameter) and a plate size of 342 mm 2 that shows good results in pediatric glaucoma patients and potentially reduces the risk of hypotony, tube erosion, and endothelial cell loss. 54…”

Wound modulation in glaucoma surgery: The role of anti-scarring agents

“…Intraoperative MMC during tube-shunt surgery has shown mixed results, with some authors reporting beneficial effects[ 21 22 ] while others reported no benefits. [ 23 ] A randomized trial by Costa et al .…”