The Outcome of Major Hepatectomies Following Different Durations of Portal Vein Ligation in Rats

Bülbüloğlu, Ertan; Şahi̇n, Mustafa; Kantarçeken, Bülent; Çıralık, Harun; Çetinkaya, Ali; İnanç, Fatma; Ezbercı, Fikret

doi:10.29333/ejgm/82269

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Portal Vein Ligation (Pvl)1

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2023

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Cited by 2 publications

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“…Alongside the length of the portal vein 10-20 gauge needle was held and 2-3 silk ligatures were tied around the portal vein. The needle was then watchfully slipped out of the ligatures allowing the portal vein to open to a diameter equal to that of a 20-gauge needle and the abdomen was closed [97]. Appropriate facilities and trained operator [112] G. S. Bhakuni et al…”

Section: Portal Vein Ligation (Pvl)mentioning

confidence: 99%

Animal models of hepatotoxicity

et al. 2015

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Section: Portal Vein Ligation (Pvl)mentioning

confidence: 99%

Animal models of hepatotoxicity

et al. 2015

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Development on Animal Models for Drug/Chemical Induced Liver Injury

Bhatia

Yogeeta

Goyal³

et al. 2023

Biomed. Pharmacol. J.

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In the human body, the largest gland is the liver and does a lot of essential work of the body. Liver damage is the cause of mortality and increasing day by day. Liver disease is caused by multiple factors, such as an autoimmune condition, toxic chemical exposure, viral infection, and dietary factors. Drug-induced liver injury (DILI) is a critical issue in drug development because DILI causes failures in clinical trials and the withdrawal of approved drugs from the market and leading to pathological changes result, including increase in SGOT, SGPT and bilirubin as well as the free radical generation. In this review, contains the animal model of hepatotoxicity with a different cause, their action mech., and procedure with dose. These models include the toxicity caused by chemical, drug, radiation, metal, diet, and high-fat this will lead to pathological changes resulting in hepatotoxicity.

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The Outcome of Major Hepatectomies Following Different Durations of Portal Vein Ligation in Rats

Cited by 2 publications

References 26 publications

Animal models of hepatotoxicity

Animal models of hepatotoxicity

Development on Animal Models for Drug/Chemical Induced Liver Injury

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