The Outcome of Antidepressant Use in the Medically Ill

Popkin, Michael K.; Callies, Allan L.; Mackenzie, Thomas B.

doi:10.1001/archpsyc.1985.01790350034007

Cited by 178 publications

(54 citation statements)

References 12 publications

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“…In addition, they also demonstrated that response to MPH therapy was significantly faster than response to nortriptyline therapy (2.4 vs. 27 days). This is consistent with the clinical experience where traditional antidepressant therapy often fails due to intolerance in up to one third of patients [23] or delayed onset of action [24]. The prevalence of depression in our study population is in line with that reported in other studies where in females, depression ranged from 5.9 to 78.3% [25] and in males from 4.7% [26] to 65.2% [27].…”

Section: Discussionsupporting

confidence: 92%

Effect of Methylphenidate and/or Levodopa Combined with Physiotherapy on Mood and Cognition after Stroke: A Randomized, Double-Blind, Placebo-Controlled Trial

Delbari¹,

Roghani

Lökk

2011

Eur Neurol

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Background/Aim: Stimulant medications can enhance mood and cognition in stroke rehabilitation, but human clinical trial results are inconclusive. We sought to prospectively study the effects of levodopa (LD) and/or methylphenidate (MPH) in combination with physiotherapy on mood and cognition following stroke in human subjects. Methods: Ischemic stroke patients were enrolled in our study 15 to 180 days after stroke onset. The patients were randomized into four medication groups (MPH, LD, MPH + LD, or placebo) and received a 15-day course of medication therapy (1 dose daily) and 45-min standard physiotherapy treatment daily. Mood and cognitive function were assessed at the study onset and 15, 90 and 180 days after study enrollment. Results: The strongest improvement of mood and cognition was found between baseline and the first follow-up immediately after the intervention. A significant improvement in mood was also found in the combined treatment group (MPH + LD) at 90 and 180 days, compared to the placebo group. Conclusions: A 15-day course of daily MPH + LD combined with physiotherapy over a 3-week period was safe and significantly improved mood status in ischemic stroke patients. Future studies are needed which determine the optimal therapeutic window for and dosage of psychostimulants as well as identify those stroke patients who might benefit the most from treatment.

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Section: Discussionsupporting

confidence: 92%

Effect of Methylphenidate and/or Levodopa Combined with Physiotherapy on Mood and Cognition after Stroke: A Randomized, Double-Blind, Placebo-Controlled Trial

Delbari¹,

Roghani

Lökk

2011

Eur Neurol

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“…If someone has met the criteria for MDE for more than 2 weeks shortly after they have been assaulted, divorced or suffered a myocardial infarct, we do not say they are not depressed and consider their reaction 'normal. ' Rather, we make the diagnosis of MDE and consider the most appropriate treatment options (Popkin et al 1985 ;Glassman et al 2002).…”

Section: Discussionmentioning

confidence: 99%

Is bereavement-related depression different than non-bereavement-related depression?

2007

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“…For mild depressive syndromes the initial treatment is to offer advice, information, explanation and practical support to people with diabetes and their families (Popkin et al, 1985). For more persistent cases, specific psychological treatment such as problem-solving therapy, cognitive-behavioural therapy or interpersonal psychotherapy may be used (although the lack of published studies of psychotherapy for depression in diabetes mean that this approach lacks an evidence base).…”

Section: Treatment Of Depression In Diabetesmentioning

confidence: 99%

Psychiatric aspects of diabetes mellitus

Trigwell¹,

Peveler²

1998

Adv. psychiatr. treat

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In 1899, Maudsley wrote:“Diabetes is a disease which often shows itself in families in which insanity prevails: whether one disease predisposes in any way to the other or not, or whether they are independent outcomes of a common neurosis, they are certainly found to run side by side, or alternately with one another more often than can be accounted for by accidental coincidence or sequence”.Recent research confirms that a range of psychological problems and psychiatric disorders are common in people with diabetes. Such problems are important not only because of the suffering caused, but also because of their impact upon the management and outcome of the diabetes itself. This article reviews the psychosocial impact of diabetes and its treatment, describes the range of psychological problems and psychiatric disorders which commonly occur in people with diabetes, and outlines the role of the psychiatrist in the recognition and management of these clinical problems.

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The Outcome of Antidepressant Use in the Medically Ill

Cited by 178 publications

References 12 publications

Effect of Methylphenidate and/or Levodopa Combined with Physiotherapy on Mood and Cognition after Stroke: A Randomized, Double-Blind, Placebo-Controlled Trial

Effect of Methylphenidate and/or Levodopa Combined with Physiotherapy on Mood and Cognition after Stroke: A Randomized, Double-Blind, Placebo-Controlled Trial

Is bereavement-related depression different than non-bereavement-related depression?

Psychiatric aspects of diabetes mellitus

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