The OTSC® proctology clip system for the closure of refractory anal fistulas

Mennigen, Rudolf; Laukötter, M; Senninger, N.; Rijcken, Emile

doi:10.1007/s10151-015-1284-7

Cited by 59 publications

(40 citation statements)

References 12 publications

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“…In a small retrospective study of 10 patients with refractory anal fistulas, including 6 patients with perianal CD, the procedure was technically successful in all patients and permanent fistula closure was achieved in 7/10 (70 %) within a median time for healing of 72 days 86. Its long-term efficacy remains to be investigated.…”

Section: The Role Of Endoscopy In the Management Of Perianal Fistulasmentioning

confidence: 99%

Modern management of perianal fistulas in Crohn’s disease: future directions

Kotze

Shen

Lightner

et al. 2018

Gut

135

104

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Perianal fistulae in patients with Crohn's disease (CD) can be associated with significant morbidity resulting in negative impact on quality of life. The last two decades have seen significant advancements in the management of perianal fistulas in CD, which has evolved into a multidisciplinary approach that includes gastroenterologists, colorectal surgeons, endoscopists and radiologists. Despite the introduction of new medical therapies such as antitumour necrosis factor and novel models of care delivery, the best fistula healing rates reported with combined medical and surgical approaches are approximately 50%. More recently, newer biologics, cell-based therapies as well as novel endoscopic and surgical techniques have been introduced raising new hopes that outcomes can be improved upon. In this review, we describe the modern management and the most recent advances in the management of complex perianal fistulising CD, which will likely impact clinical practice. We will explore optimal use of both older and newer biological agents, as well as new data on cell-based therapies. In addition, new techniques in endoscopic and surgical approaches will be discussed.

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Section: The Role Of Endoscopy In the Management Of Perianal Fistulasmentioning

confidence: 99%

Modern management of perianal fistulas in Crohn’s disease: future directions

Kotze

Shen

Lightner

et al. 2018

Gut

135

104

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“…A summary of study characteristics is shown in Table 1, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75.…”

Section: Resultsmentioning

confidence: 99%

“…A single case series68 reported the use of OTSC ® in anal fistula. Of the ten patients treated, six had fistula associated with Crohn's disease.…”

Section: Resultsmentioning

confidence: 99%

Systematic review of surgical interventions for Crohn's anal fistula

Lee

Heywood²,

Adegbola

et al. 2017

BJS Open

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BackgroundAnal fistula occurs in approximately one in three patients with Crohn's disease and is typically managed through a multimodal approach. The optimal surgical therapy is not yet clear. The aim of this systematic review was to identify and assess the literature on surgical treatments of Crohn's anal fistula.MethodsA systematic review was conducted that analysed studies relating to surgical treatment of Crohn's anal fistula published on MEDLINE, Embase and Cochrane databases between January 1995 and March 2016. Studies reporting specific outcomes of patients treated for Crohn's anal fistula were included. The primary outcome was fistula healing rate. Bias was assessed using the Cochrane ROBINS‐I and ROB tool as appropriate.ResultsA total of 1628 citations were reviewed. Sixty‐three studies comprising 1584 patients were ultimately selected in the analyses. There was extensive reporting on the use of setons, advancement flaps and fistula plugs. Randomized trials were available only for stem cells and fistula plugs. There was inconsistency in outcome measures across studies, and a high degree of bias was noted.ConclusionData describing surgical intervention for Crohn's anal fistula are heterogeneous with a high degree of bias. There is a clear need for standardization of outcomes and description of study cohorts for better understanding of treatment options.

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“…En 3 de los 7 pacientes con cierre de la fístula, se pudo retirar el clip posteriormente. 31 9) Estoma derivativo. Proctectomía En 2016 se publicó un estudio prospectivo en el que se analizaron los resultados tras realizar un estoma derivativo indicado por afectación colónica o perianal de la enfermedad de Crohn 32 .…”

Section: ) Over-the-scope-clip (Otsc)unclassified

Situación Actual en el Tratamiento de la Enfermedad de Crohn Perianal.

Alcolea

2019

Arch. coloproctol.

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La afectación perianal tiene lugar en un tercio de los pacientes con enfermedad de Crohn, impactando negativamente en su calidad de vida. A pesar de su frecuencia, actualmente carecemos de evidencia clínica suficiente para realizar un consenso de manejo de la enfermedad. La presente revisión tiene como objetivo resumir los resultados obtenidos en los estudios publicados en los últimos diez años.

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The OTSC® proctology clip system for the closure of refractory anal fistulas

Abstract: The novel OTSC(®) proctology system is a safe and effective method for the closure of even complex and recurrent fistulas.

Cited by 59 publications

References 12 publications

Modern management of perianal fistulas in Crohn’s disease: future directions

Modern management of perianal fistulas in Crohn’s disease: future directions

Systematic review of surgical interventions for Crohn's anal fistula

Situación Actual en el Tratamiento de la Enfermedad de Crohn Perianal.

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