“The other side of the coin”: understanding noninvasive follicular tumor with papillary-like nuclear features in unifocal and multifocal settings

Canberk, Şule; Montezuma, Diana; Taştekin, Ebru; Grangeia, Diana; Demirhas, Mehmet Polat; Akbas, Meryem; Tokat, Fatma; İnce, Ümit; Soares, Paula; Schmitt, Fernando

doi:10.1016/j.humpath.2018.10.040

Cited by 25 publications

(20 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The predictions, which were based on retrospective data from four institutions (three Italian and one American), resulted in a calculated rate of NIFTP of 18.6% among all PTC cases (4). After more than 3 years from the introduction of the new nomenclature, it appears that the initial calculations were overestimated (8,9,10,11,12,13,14,15,16,17,18,19,20,21).…”

Section: Epidemiologymentioning

confidence: 99%

Section: Clinical and Ultrasonographic Featuresmentioning

confidence: 99%

“…In clinical practice, NIFTP presents as a single nodule (10) or a lesion in the context of a multinodular background (27, 40, 41). The multifocal form of NIFTP is present in 2.7-14.7% of patients (10,40,42). The coexistence of a malignant lesion in the same or in the second lobe of the thyroid may affect 14.9-46.3% of NIFTP patients (it most often coexists with papillary thyroid microcarcinoma) (10,21,41).…”

Section: Clinical and Ultrasonographic Featuresmentioning

confidence: 99%

Section: Treatment and Monitoringmentioning

confidence: 99%

“…Decisions on the extent of surgery should consider that bilateral disease and multifocal disease are part of the spectrum of NIFTP neoplasms (10,40,42). The coexistence of malignant lesions in the same or the other thyroid lobe may affect up to 15-46% of NIFTP patients (10,21,41). In the study by Canberk et al, 15% of NIFTP cases (11/74) were accompanied by malignant lesions in the contralateral thyroid lobe, including five PTCs, five microcarcinoma FVPTCs and one IFVPTC; two of the contralateral malignancies showed microscopic extrathyroidal extension (10).…”

Section: Treatment and Monitoringmentioning

confidence: 99%

See 4 more Smart Citations

Noninvasive follicular thyroid neoplasm with papillary-like nuclear features: a problematic entity

Zajkowska

Kopczyński

Góźdż

et al. 2020

Endocrine Connections

View full text Add to dashboard Cite

Noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is a borderline thyroid tumour formerly known as noninvasive encapsulated follicular variant of papillary thyroid carcinoma. The prevalence of NIFTP is estimated at 4.4–9.1% of all papillary thyroid carcinomas worldwide; however, the rate of occurrence of NIFTP is eight times lower in Asian countries than in Western Europe and America. At the molecular level, NIFTP is characterised by the lack of BRAF V600E and BRAF V600E-like mutations or other high-risk mutations (TERT, TP53) and a high rate of RAS mutations, which is similar to other follicular-pattern thyroid tumours. The diagnosis of NIFTP can only be made after histological examination of the entire tumour removed during surgery and is based on strictly defined inclusion and exclusion criteria. Although the diagnosis is postoperative, the combination of certain findings of preoperative tests including ultrasonography, cytology, and molecular testing may raise suspicion of NIFTP. These tumours can be effectively treated by lobectomy, although total thyroidectomy remains an option for some patients. Radioactive iodine and thyroid stimulating hormone suppression therapy are not required. NIFTP has an extremely good prognosis, even when treated conservatively with lobectomy alone. Nevertheless, it cannot be considered as a benign lesion. The risk of adverse outcomes, including lymph node and distant metastases, is low but not negligible.

show abstract