The other side of atopic dermatitis: An evaluation of psychosocial comorbidities

Pandher, Karan; Patel, Keshav; Wang, Jordan V; Saedi, Nazanin

doi:10.1016/j.clindermatol.2020.07.002

Cited by 6 publications

(6 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Accumulating evidence has demonstrated that neuropsychiatric disorders like depression and anxiety occur frequently in AD patients and animal models . The psychological stress and mental disorders could exacerbate the pruritus and impair the skin barrier, thus evoking the vicious cycle implicated in the progression of AD . In the present study, FST, TST, OFT, and EZM were performed to evaluate the psychological behaviors of each mouse.…”

Section: Discussionmentioning

confidence: 97%

“…40 The psychological stress and mental disorders could exacerbate the pruritus and impair the skin barrier, thus evoking the vicious cycle implicated in the progression of AD. 41 In the present study, FST, TST, OFT, and EZM were performed to evaluate the psychological behaviors of each mouse. The OFT was adopted to observe the locomotor activity and exploration desire of animals, FST/ TST was adopted to measure depression-like behaviors, and EZM was adopted to detect anxiety-like disorders.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Dietary Galacto-oligosaccharides Ameliorate Atopic Dermatitis-like Skin Inflammation and Behavioral Deficits by Modulating Gut Microbiota–Brain–Skin Axis

Tang,

Cao,

Chen

et al. 2024

J. Agric. Food Chem.

View full text Add to dashboard Cite

Atopic dermatitis (AD), a chronic, highly pruritic, and inflammatory skin disorder, often coexists with psychiatric comorbidities including anxiety and depression, posing considerable challenges for treatment. The current research aims at evaluating the efficacy and potential therapeutic mechanism of galacto-oligosaccharides (GOS) on AD-like skin lesions and comorbid anxiety/depressive disorders. Macroscopical and histopathological examination showed that GOS could markedly relieve skin inflammation by decreasing the production of IgE, IL-4, IL-13, IFN-γ, and TNF-α and regulating the PPAR-γ/NF-κB signaling in DNFB-induced AD mice. Moreover, GOS significantly improved the anxiety- and depressive-like symptoms as mirrored by the behavior tests including FST, TST, OFT, and EZM through normalizing the neurotransmitter levels of 5-HT, DA, NE, and CORT in the brain. Mechanistically, by virtue of the high-throughput 16S rRNA gene sequencing and GC-MS techniques, GOS restructured the gut microbiota and specifically induced the proliferation of Lactobacillus and Alloprevotella, leading to an increase in the total content of fecal SCFAs, in particular acetate and butyrate. Pearson correlation analysis found a marked correlation among the altered gut microbiota/SCFAs, AD-associated skin manifestations, and comorbid behavioral phenotypes. Collectively, this work highlights that GOS is a promising strategy against both AD and associated depressive symptoms by modulating the gut microbiota-brain–skin axis.

show abstract

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Dietary Galacto-oligosaccharides Ameliorate Atopic Dermatitis-like Skin Inflammation and Behavioral Deficits by Modulating Gut Microbiota–Brain–Skin Axis

Tang,

Cao,

Chen

et al. 2024

J. Agric. Food Chem.

View full text Add to dashboard Cite

show abstract

“…First, due to the cross-sectional study design, it was difficult to explain the causality between AD and suicidal behaviors in adolescent defectors. Second, it is unclear from the data whether dermatological treatments have an impact on suicidal behavior [ 48 , 49 ]. Therefore, dermatologists should take steps to prevent suicide among adolescent AD patients [ 50 , 51 ].…”

Section: Discussionmentioning

confidence: 99%

“…Second, it is unclear from the data whether dermatological treatments have an impact on suicidal behavior. 48,49 Therefore, dermatologists should take steps to prevent suicide among adolescent AD patients. 50,51 Furthermore, the confirmation of association between AD and suicidal behaviors in this vulnerable population suggests that the clinical presentation of AD may represent a valuable opportunity for primary care physicians to initiate discussions about mental healthcare, which may otherwise be stigmatized or inaccessible in this population.…”

Section: Discussionmentioning

confidence: 99%

Association Between Atopic Dermatitis and Suicidal Behaviors in North Korean Adolescent Defectors From 2011 to 2019

Jang,

Seo,

Kim

et al. 2024

Psychiatry Investig

View full text Add to dashboard Cite

Objective To evaluate the association between atopic dermatitis (AD) and suicidal behaviors in adolescent defectors among residents who escaped from North Korean (adolescent defectors, n=423) and adolescents with South Korean parents (Korean adolescents, n=540,265).Methods The study used data from the Korea Youth Risk Behavior Survey conducted from 2011 to 2019. Differences in general characteristics, health behaviors, suicidal ideation, suicide plans, suicide attempts, and AD between adolescent defectors and Korean adolescents were examined. Multiple logistic regression analysis was used to determine the association between AD and suicidal behaviors.Results The adolescent defectors group had lower AD (16.3% vs. 24.2%), poorer subjective health (10% vs. 6%), smoked more (47% vs. 18%), drank more (60% vs. 43%), lived with family less frequently (56% vs. 96%), and were more than twice as likely to have depression (42% vs. 27%), suicidal ideation (30% vs. 14%), a suicide plan (23% vs. 5%), or have made a prior suicide attempt (19% vs. 3%) compared with the Korean adolescent group (p<0.001). The adjusted odds ratio for the adolescent defectors group compared to the Korean adolescent group was 1.66 for suicidal ideation, 3.59 for suicide plans, and 4.34 for suicide attempts (p<0.001). AD was found to be associated with suicide plans and attempts in adolescent defectors and associated with suicidal ideation in Korean adolescents.Conclusion AD was significantly associated with suicide plans and suicidal attempts among adolescent defectors and suicidal ideation in Korean adolescents, based on a random sample of middle- and high-school students.

show abstract

“… 5 Additional publications linked AD to risk of suicide, stress, and overall dissatisfaction with life in both patients and caregivers. 6 , 7 Many medical conditions may unmask or exacerbate behavioural health conditions. However, chronic itch represents a special, underappreciated case wherein the biologic pathology of pruritis is related to the pathology of anxiety, beyond the psychosocial impacts of the disease.…”

Section: Tablementioning

confidence: 99%

What are patients saying about their experience with atopic dermatitis? Insights from a machine learning analysis of online comments

Yin

Capozza

Shao

et al. 2022

Skin Health and Disease

View full text Add to dashboard Cite

The other side of atopic dermatitis: An evaluation of psychosocial comorbidities

Cited by 6 publications

References 21 publications

Dietary Galacto-oligosaccharides Ameliorate Atopic Dermatitis-like Skin Inflammation and Behavioral Deficits by Modulating Gut Microbiota–Brain–Skin Axis

Dietary Galacto-oligosaccharides Ameliorate Atopic Dermatitis-like Skin Inflammation and Behavioral Deficits by Modulating Gut Microbiota–Brain–Skin Axis

Association Between Atopic Dermatitis and Suicidal Behaviors in North Korean Adolescent Defectors From 2011 to 2019

What are patients saying about their experience with atopic dermatitis? Insights from a machine learning analysis of online comments

Contact Info

Product

Resources

About