The osteogenic, inflammatory and osteo-immunomodulatory performances of biomedical Ti-Ta metal–metal composite with Ca- and Si-containing bioceramic coatings

Huang, Qianli; Li, Xuezhong; Elkhooly, Tarek A.; Xu, Shenghang; Liu, Xujie; Feng, Qingling; Wu, Hong; Liu, Yong

doi:10.1016/j.colsurfb.2018.05.010

Cited by 31 publications

(21 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Collagen synthesis and calcium deposition are indicators reflecting the middle and late stages of osteoblast differentiation, respectively. 51 As shown in Fig. 7B, the amount of collagen synthesis of BMSCs was significantly enhanced on the PA–Fe/Cu 5 surface compared to the control group after culturing for 10 days.…”

Section: Resultsmentioning

confidence: 73%

One-stepin situdeposition of phytic acid–metal coordination complexes for combinedPorphyromonas gingivalisinfection prevention and osteogenic induction

et al. 2022

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 73%

One-stepin situdeposition of phytic acid–metal coordination complexes for combinedPorphyromonas gingivalisinfection prevention and osteogenic induction

et al. 2022

View full text Add to dashboard Cite

show abstract

“…This strongly proves that CAG promoted macrophage polarization toward M2 phenotype more substantially than BAG or AG ( 50 ). Cytokine secretion was detected by quantitative reverse transcription polymerase chain reaction (qRT-PCR) to determine the inflammatory factor release of macrophages after hydrogel treatment ( 51 ). The expression of tumor necrosis factor–α (TNF-α), interleukin-1β (IL-1β), and IL-6 was decreased in CAG group compared with those in other groups ( P < 0.05; Fig.…”

Section: Resultsmentioning

confidence: 99%

“…5H ). In this regard, CAG was considered to promote the M2 phenotype transition and a local anti-inflammatory microenvironment, probably by up-regulating the expression of IL-10 and down-regulating the expression of TNF-α, IL-1β, and IL-6 ( 51 ).…”

Section: Resultsmentioning

confidence: 99%

A biopolymer hydrogel electrostatically reinforced by amino-functionalized bioactive glass for accelerated bone regeneration

et al. 2021

View full text Add to dashboard Cite

show abstract

“…TNFα is a master cytokine during inflammation and a potent inducer of other proinflammatory chemokines and cytokines. When focussing on inflammatory cytokines, the Ta-based surface seems to exert an anti-inflammatory effect compared to the Ti-based surface [43], suggesting that Ta substrates are more biologically inert and may provide a more favorable environment when applied as biomaterial. However, other studies reported that Ta-based surfaces could be more inflammatory than Ti-based [44] surfaces.…”

Section: Discussionmentioning

confidence: 99%

Investigation of Cytotoxicity, Oxidative Stress, and Inflammatory Responses of Tantalum Nanoparticles in THP-1-Derived Macrophages

Zhang

Haddouti

Beckert

et al. 2020

Mediators of Inflammation

View full text Add to dashboard Cite

Tantalum (Ta) is gaining attention as a biomaterial in bone tissue engineering. Although the clinical advantage of Ta-based implants for primary and revision total joint replacement (TJA) has been well documented, few studies investigated the effect of wear products of Ta implants on peri-implant cells, and their potential contribution to aseptic implant loosening. This study is aimed at examining the cytotoxicity, oxidative stress, and proinflammatory potential of Ta and TiO2 nanoparticles (NPs) on macrophages in vitro. NPs were characterized using scanning electron microscopy, dynamic light scattering, and energy-dispersive X-ray. To test the NP-mediated cellular response in macrophages, THP-1-derived macrophages were challenged with both NPs, and cytotoxicity was analyzed using CCK-8 and LDH assays. Flow cytometry was used to investigate particle uptake and their internalization routes. NP-mediated oxidative stress was investigated by measuring the production of reactive oxygen species, and their proinflammatory potential was determined by quantifying the production of TNFα and IL-1β in cell culture supernatants using ELISA. We found that both Ta and TiO2 NPs were taken up through actin-dependent phagocytosis, although TiO2 NPs did also show some involvement of macropinocytosis and clathrin-mediated endocytosis. Ta NPs caused no apparent toxicity, while TiO2 NPs demonstrated significant cytotoxicity at a concentration of over 100μg/mL at 24 h. Ta NPs induced negligible ROS generation and proinflammatory cytokines (TNFα, IL-1β) in macrophages. In contrast, TiO2 NPs markedly induced these effects in a dose-dependent manner. Our findings indicate that Ta NPs are inert, nontoxic, and noninflammatory. Therefore, Ta could be considered an excellent biomaterial in primary and revision joint arthroplasty implants.

show abstract

The osteogenic, inflammatory and osteo-immunomodulatory performances of biomedical Ti-Ta metal–metal composite with Ca- and Si-containing bioceramic coatings

Cited by 31 publications

References 39 publications

One-stepin situdeposition of phytic acid–metal coordination complexes for combinedPorphyromonas gingivalisinfection prevention and osteogenic induction

One-stepin situdeposition of phytic acid–metal coordination complexes for combinedPorphyromonas gingivalisinfection prevention and osteogenic induction

A biopolymer hydrogel electrostatically reinforced by amino-functionalized bioactive glass for accelerated bone regeneration

Investigation of Cytotoxicity, Oxidative Stress, and Inflammatory Responses of Tantalum Nanoparticles in THP-1-Derived Macrophages

Contact Info

Product

Resources

About