The osteogenic activity of strontium loaded titania nanotube arrays on titanium substrates

Zhao, Lei; Wang, Hairong; Huo, Kaifu; Zhang, Xuming; Wang, Wei; Zhang, Yumei; Wu, Zhifen; Chu, Paul K.

doi:10.1016/j.biomaterials.2012.09.041

Cited by 213 publications

(161 citation statements)

References 47 publications

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“…The materials can be fabricated easily by simple and economic anodizing, and the nanotube dimensions can be precisely controlled. 6,19,23,26 Recently, other nanofeatures have emerged as a new class of nanoscales because of their physical and chemical properties. Because of some advantages such as appropriate crystallization temperature, environmental friendliness, controllability of reaction conditions, low energy consumption, and low cost, the hydrothermal method has been considered a suitable synthetic route.…”

Section: Introductionmentioning

confidence: 99%

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Osteogenic activity of titanium surfaces with nanonetwork structures

Huan¹,

Komasa²,

Taguchi³

et al. 2014

IJN

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Background Titanium surfaces play an important role in affecting osseointegration of dental implants. Previous studies have shown that the titania nanotube promotes osseointegration by enhancing osteogenic differentiation. Only relatively recently have the effects of titanium surfaces with other nanostructures on osteogenic differentiation been investigated. Methods In this study, we used NaOH solutions with concentrations of 2.5, 5.0, 7.5, 10.0, and 12.5 M to develop a simple and useful titanium surface modification that introduces the nanonetwork structures with titania nanosheet (TNS) nanofeatures to the surface of titanium disks. The effects of such a modified nanonetwork structure, with different alkaline concentrations on the osteogenic differentiation of rat bone marrow mesenchymal stem cells (BMMSCs), were evaluated. Results The nanonetwork structures with TNS nanofeatures induced by alkali etching markedly enhanced BMMSC functions of cell adhesion and osteogenesis-related gene expression, and other cell behaviors such as proliferation, alkaline phosphatase activity, extracellular matrix deposition, and mineralization were also significantly increased. These effects were most pronounced when the concentration of NaOH was 10.0 M. Conclusion The results suggest that nanonetwork structures with TNS nanofeatures improved BMMSC proliferation and induced BMMSC osteogenic differentiation. In addition, the surfaces formed with 10.0 M NaOH suggest the potential to improve the clinical performance of dental implants.

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Section: Introductionmentioning

confidence: 99%

“…19,20 There are numerous ways that the implant surface can be modified to have nanoscale features added to these surfaces in combination. The most common are chemical processes such as alkaline hydrothermal 20,24,25 or acid 6,15,17,22 oxidation on titanium surfaces to create different nanoscale topographies.…”

Section: Introductionmentioning

confidence: 99%

Osteogenic activity of titanium surfaces with nanonetwork structures

Huan¹,

Komasa²,

Taguchi³

et al. 2014

IJN

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“…These methods include strontium-substituted hydroxyapatite implants, modification of metal oxide layers with a strontium-containing salt, generation of strontium titanate nanotubes on the surfaces of metal implants, bioactive glass comprising strontium, and incorporation of strontium into metal oxide layers on implant surfaces. [23][24][25][26][27] Strontium that is incorporated into bone cements has been found to improve bone formation and reduce bone resorption in vivo. 28 Sabareeswaran et al investigated the bioactive fixation of strontium-containing glass ceramics and found out that it led to osseointegration during shortterm implementation.…”

Section: Discussionmentioning

confidence: 99%

Histopathological evaluation of the effect of locally administered strontium on healing time in mandibular fractures: An experimental study

Durmuş¹,

Turgut²,

Doğan³

et al. 2017

Adv Clin Exp Med

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“…8,28 Although the NT-Sr surface showed lower cell adhesion than the MT surface did, the proliferation and ALP activity of the two groups were significantly enhanced, and a similar phenomenon was observed by Zhao et al who found that the microtexture induces inconsistent osteoblast functions with enhanced initial cell adhesion and osteogenesis-related gene expressions but depressed effects on other cell behaviors including proliferation, ALP activity, and mineralization. 22,29 Cell behaviors consist of adhesion, intracellular protein synthesis, proliferation, differentiation, extracellular matrix deposition, and mineralization. Cell adhesion is only the initial step during the functional process of osteoblasts.…”

Section: Discussionmentioning

confidence: 99%

“…13,29 Furthermore, the local administration of Sr has been attempted, including Sr-substituted hydroxyapatites modification, modification of metal-oxide layers with an Sr-containing salt, generation of strontium titanate (SrTiO 3 ) nanotubes on the surface of metal implants, 26 bioactive glasses comprising Sr, 32 and Sr incorporation into metal-oxide layers on implant surfaces. [33][34][35] In our animal experiment, although the NT-Sr surface decreased in BIC% and maximal pullout force, enhanced bone-mineralization deposition rate was observed on Sr-loaded surfaces.…”

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confidence: 99%

Effects of a micro/nano rough strontium-loaded surface on osseointegration

Li¹,

Qi²,

Gao³

et al. 2015

IJN

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We developed a hierarchical hybrid micro/nanorough strontium-loaded Ti (MNT-Sr) surface fabricated through hydrofluoric acid etching followed by magnetron sputtering and evaluated the effects of this surface on osseointegration. Samples with a smooth Ti (ST) surface, micro Ti (MT) surface treated with hydrofluoric acid etching, and strontium-loaded nano Ti (NT-Sr) surface treated with SrTiO 3 target deposited via magnetron sputtering technique were investigated in parallel for comparison. The results showed that MNT-Sr surfaces were prepared successfully and with high interface bonding strength. Moreover, slow Sr release could be detected when the MNT-Sr and NT-Sr samples were immersed in phosphate-buffered saline. In in vitro experiments, the MNT-Sr surface significantly improved the proliferation and differentiation of osteoblasts compared with the other three groups. Twelve weeks after the four different surface implants were inserted into the distal femurs of 40 rats, the bone–implant contact in the ST, MT, NT-Sr, and MNT-Sr groups were 39.70%±6.00%, 57.60%±7.79%, 46.10%±5.51%, and 70.38%±8.61%, respectively. In terms of the mineral apposition ratio, the MNT-Sr group increased by 129%, 58%, and 25% compared with the values of the ST, MT, and NT-Sr groups, respectively. Moreover, the maximal pullout force in the MNT-Sr group was 1.12-, 0.31-, and 0.69-fold higher than the values of the ST, MT, and NT-Sr groups, respectively. These results suggested that the MNT-Sr surface has a synergistic effect of hierarchical micro/nano-topography and strontium for enhanced osseointegration, and it may be a promising option for clinical use. Compared with the MT surface, the NT-Sr surface significantly improved the differentiation of osteoblasts in vitro. In the in vivo animal experiment, the MT surface significantly enhanced the bone-implant contact and maximal pullout force than the NT-Sr surface.

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The osteogenic activity of strontium loaded titania nanotube arrays on titanium substrates

Cited by 213 publications

References 47 publications

Osteogenic activity of titanium surfaces with nanonetwork structures

Osteogenic activity of titanium surfaces with nanonetwork structures

Histopathological evaluation of the effect of locally administered strontium on healing time in mandibular fractures: An experimental study

Effects of a micro/nano rough strontium-loaded surface on osseointegration

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