The Osteoarthritis Knee Model: Psychophysical Characteristics and Putative Outcomes

Harden, R. Norman; Wallach, G.; Gagnon, Christine; Zereshki, Arzhang; Mukai, Ai; Saraçoğlu, Mehmet; Kuroda, Maxine M.; Graciosa, Joseph R.; Bruehl, Stephen

doi:10.1016/j.jpain.2012.11.009

Cited by 27 publications

(24 citation statements)

References 66 publications

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“…The main methods for the physical characteristics are the Von Frey method, the thermal wind-up method and the functional wind-up method [27]. The functional wind-up method was selected to evaluate the pain caused by OA.…”

Section: Discussionmentioning

confidence: 99%

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Preparation of Low Molecular Weight Chondroitin Sulfates, Screening of a High Anti-Complement Capacity of Low Molecular Weight Chondroitin Sulfate and Its Biological Activity Studies in Attenuating Osteoarthritis

Feng

et al. 2016

IJMS

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Chondroitin sulfate (CS) plays important roles in the complement system. However, the CS structure is complicated due to different sources and the number and positions of sulfate groups. The objective of this study was to prepare different low molecular weight chondroitin sulfates (LMWCSs) and to investigate the biological activity in anti-complement capacity. A series of LMWCSs was prepared from different sources and characterized by ultraviolet-visible (UV) spectroscopy, high-performance liquid chromatography (HPLC), size exclusion chromatography-multiangle laser light scattering (SEC-MALLS) and nuclear magnetic resonance (NMR) spectroscopy. Hemolytic, anti-complement 3 deposition capacity and cell viability assays were carried out to investigate the biological activities in vitro. The results showed that LMWCS prepared from shark cartilage with the oxidative degradation method (LMWCS-S-O) had the best anti-complement capacity. LMWCS-S-O could inhibit the alternative pathway of the complement system and protect chondrocytes from cell death. The attenuating effect of LMWCS-S-O on Osteoarthritis (OA) was investigated by destabilization of the medial meniscus (DMM) model in vivo. Functional wind-up, histological and C5b-9 analyses were used to evaluate the treatment effect on the OA model. In vivo results showed that LMWCS-S-O could attenuate OA. LMWCS-S-O with a high content of ΔDi-2,6diS and ΔDi-6S could be used for attenuating OA through regulating the complement system.

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Section: Discussionmentioning

confidence: 99%

“…A modified FWU method [27] was used to measure the supporting force difference of two hind legs after 12 weeks of surgery. A climbing task with a 60 degree angle was performed.…”

Section: Methodsmentioning

confidence: 99%

Preparation of Low Molecular Weight Chondroitin Sulfates, Screening of a High Anti-Complement Capacity of Low Molecular Weight Chondroitin Sulfate and Its Biological Activity Studies in Attenuating Osteoarthritis

Feng

et al. 2016

IJMS

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“…Although knee OA has been considered the archetypal model of noninflammatory or nociceptive pain5 it is now recognized that some patients with knee OA also exhibit features of neuropathic pain,6 which may be associated with sensory deficits and widespread multimodality hyperalgesia 7…”

mentioning

confidence: 99%

Cold Pain Threshold Identifies a Subgroup of Individuals With Knee Osteoarthritis That Present With Multimodality Hyperalgesia and Elevated Pain Levels

Wright

Benson

Will³

et al. 2017

The Clinical Journal of Pain

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Objectives: Cold hyperalgesia has been established as an important marker of pain severity in a number of conditions. This study aimed to establish the extent to which patients with knee osteoarthritis (OA) demonstrate widespread cold, heat, and pressure hyperalgesia. OA participants with widespread cold hyperalgesia were compared with the remaining OA cohort to determine whether they could be distinguished in terms of hyperalgesia, pain report, pain quality, and physical function.Methods: A total of 80 participants with knee OA and 40 matched healthy, pain-free controls participated. OA participants completed a washout of their usual medication. Quantitative sensory testing was completed at 3 sites using standard methods. Cold pain threshold (CPT) and heat pain thresholds (HPT) were tested using a Peltier thermode and pressure pain thresholds (PPT) using a digital algometer. All participants completed the short-form health survey questionnaire and OA participants completed the PainDETECT, Western Ontario and McMaster Universities Osteoarthritis Index of the Knee (WOMAC), and pain quality assessment scale questionnaires.Results: OA participants demonstrated widespread cold hyperalgesia (P < 0.0001), had lower PPT at the index knee (P < 0.0001) compared with controls and reported decreased physical health on the SF-36 (P = 0.01). The OA subcohort with high global CPT (Z12.251C) exhibited multimodality sensitization compared with the remaining OA cohort (PPT P < 0.0001; CPT P < 0.0001; HPT P = 0.021 index knee). This group also reported increased pain, decreased function, and more features of neuropathic pain.Discussion: This study identified a specific subgroup of patients with knee OA who exhibited widespread, multimodality hyperalgesia, more pain, more features of neuropathic pain, and greater functional impairment. Identification of patients with this pain phenotype may permit more targeted and effective pain management.

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“…Bajaj et al [19] reported that both the area and intensity of secondary hyperalgesia were increased in subjects with knee OA, following hypertonic saline injection into the tibialis anterior muscle. Temporal summation is also significantly facilitated in this patient group [15,17]. Studies have also found conditioned pain modulation processes to be significantly reduced in patients with OA compared with normals [20].…”

Section: Introductionmentioning

confidence: 56%

“…Thus it has been proposed that even in an apparently localised musculoskeletal condition such as OA there may be significant central augmentation of nociceptive input [17,18]. This hypothesis is also supported by studies that have reported changes in other centrally mediated pain phenomena in subjects with OA.…”

Section: Introductionmentioning

confidence: 88%

Subjects with Knee Osteoarthritis Exhibit Widespread Hyperalgesia to Pressure and Cold

Moss¹,

Knight²,

Wright³

2015

J Pain Relief

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Hyperalgesia to mechanical and thermal stimuli are characteristics of a range of disorders such as tennis elbow, whiplash and fibromyalgia. This study evaluated the presence of mechanical and thermal hyperalgesia in individuals with knee osteoarthritis (OA), compared to healthy control subjects.Twenty-three subjects with knee OA and 23 healthy controls, matched for age, gender and BMI, were recruited for the study. Volunteers with any additional chronic pain conditions were excluded. Pain thresholds to pressure (PPT), cold (CPT) and heat (HPT) were tested at the knee, ipsilateral heel and elbow, in randomized order, using standardised methodology. Significant between-groups differences for PPT and CPT were found: OA subjects demonstrated significantly increased sensitivity to both pressure (p=0.018) and cold (p=0.003), but not to heat (p=0.167) stimuli, compared with controls. A similar pattern of results extended to the pain-free ipsilateral ankle and elbow indicating widespread pressure and cold hyperalgesia. This study found widespread elevated pain thresholds in subjects with painful knee OA, suggesting that altered nociceptive system processing may play a role in ongoing arthritic pain for some patients.

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The Osteoarthritis Knee Model: Psychophysical Characteristics and Putative Outcomes

Cited by 27 publications

References 66 publications

Preparation of Low Molecular Weight Chondroitin Sulfates, Screening of a High Anti-Complement Capacity of Low Molecular Weight Chondroitin Sulfate and Its Biological Activity Studies in Attenuating Osteoarthritis

Preparation of Low Molecular Weight Chondroitin Sulfates, Screening of a High Anti-Complement Capacity of Low Molecular Weight Chondroitin Sulfate and Its Biological Activity Studies in Attenuating Osteoarthritis

Cold Pain Threshold Identifies a Subgroup of Individuals With Knee Osteoarthritis That Present With Multimodality Hyperalgesia and Elevated Pain Levels

Subjects with Knee Osteoarthritis Exhibit Widespread Hyperalgesia to Pressure and Cold

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