The osteo-odonto-keratoprosthesis

Zarei-Ghanavati, Mehran; Avadhanam, Venkata; Perez, Alfonso Vasquez; Liu, Christopher

doi:10.1097/icu.0000000000000388

Cited by 28 publications

(23 citation statements)

References 23 publications

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“…OOKP was challenging in both cases due to the demanding surgery in eyes with previous multiple adnexal and ocular surface procedures. The absence of extraocular rectus muscles represented a drawback for the BM graft as they provide vascular supply and reduce the risk of ulcerations 8, 9. Both of our cases developed BM ulcerations being more severe in our first patient in whom we only identified the lateral rectus.…”

Section: Discussionmentioning

confidence: 68%

“…In the long run, both resulted in severe dryness and corneal scarring. In this scenario, the hostile environment of the ocular surface carries a poor prognosis for corneal transplantation or even Boston KPro Type 1 6, 9. Having only one eye, both cases were referred to our center because only biological KPro could provide long-term anatomical and visual success.…”

Section: Discussionmentioning

confidence: 99%

“…Osteo-odonto-keratoprosthesis (OOKP) is a biological and the most enduring type of KPro that offers visual rehabilitation in end-stage ocular surface diseases with severe dryness 7, 8, 9. The procedure is performed in two stages: in stage 1, an alveo-dental lamina is made from a single rooted tooth (usually the canine) which harbors an optical cylinder on its center.…”

Section: Introductionmentioning

confidence: 99%

“…At the same sitting, the ocular surface is prepared and buccal mucous membrane is grafted onto the eye. During this stage (usually 2–4 months later), the lamina is retrieved, the mucosa is lifted off the globe followed by removal of the central cornea, iris, lens and anterior vitreous, and the lamina is then sutured to the sclera, which is finally covered by the buccal mucosa (BM) 7, 8, 9…”

Section: Introductionmentioning

confidence: 99%

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The Osteo-odonto-keratoprosthesis to restore vision after severe dog bite injury

Zarei-Ghanavati

Vasquez-Perez

Bardan

et al. 2019

Journal of Current Ophthalmology

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Purpose To present our experience in Osteo-odonto-keratoprosthesis (OOKP) as the only option to restore vision after severe ocular dog bite injuries. Methods We describe our results in OOKP performed in two patients with previous severe dog bite facial injuries that required exenteration of one eye and facial reconstruction. Results Both cases achieved initially successful anatomical and visual outcome; however, one case suffered retinal detachment after one year. Buccal mucosa (BM) ulcerations and tilted lamina were present as a result of extraocular muscles loss, and both were difficult to treat. Conclusion OOKP has the capability to restore vision in the most challenging cases of ocular trauma; however, refractory BM ulcerations and tilted lamina could be expected as a result of an ischemic ocular surface and orbital pulleys loss.

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Section: Discussionmentioning

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The Osteo-odonto-keratoprosthesis to restore vision after severe dog bite injury

Zarei-Ghanavati

Vasquez-Perez

Bardan

et al. 2019

Journal of Current Ophthalmology

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“…Moreover, technical improvements were done for treatment of postoperative complications including endoscopic vitrectomy, tube shunt operation for glaucoma, and augmentation of OOKP lamina by bone morphogenetic protein. [12][13][14]…”

Section: Current Choices Of Kprosmentioning

confidence: 99%

Keratoprosthesis: Current Choices and Future Development

Zarei-Ghanavati

Liu

2019

Asia-Pacific Journal of Ophthalmology

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Keratoprosthesis (KPro) is the last resort for corneal blindness. Boston KPro I and osteo-odonto-keratoprosthesis (OOKP) have the most favorable outcomes for their respective indications. Recently, better outcomes have been achieved for these 2 devices mainly because of improvements in postoperative care and modifications in complication management through years of experience and research. Unfortunately, some patients cannot benefit from these KPros due to lack of access to devices, trained surgeons, or both. Boston KPro I is heading toward a more affordable variation particularly for patients in developing countries. In addition, more patients with severely compromised ocular surface will be candidates for Boston KPro II variants. Biosynthetic or synthetic OOKP analogues will make the operation less complex and suitable for patients without canine tooth.

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High modulus hydrogels for ophthalmic and related biomedical applications

Bhamra

Tighe

2018

J Biomed Mater Res

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This paper presents three families of semi‐interpenetrating polymer network (SIPN) hydrogels based on an ester‐based polyurethane (EBPU) and hydrophilic monomers: N,N‐dimethylacrylamide (NNDMA), N‐vinyl pyrrolidone (NVP) and acryloylmorpholine (AMO) as potential materials for keratoprosthesis, orthokeratology and mini‐scleral lens application. Hydrogels sheets were synthesized via free‐radical polymerization with methods developed in‐house. SIPN hydrogels were characterized for their equilibrium water content, mechanical and surface properties. Three families of optically clear SIPN‐based hydrogels have been synthesized in the presence of water with >10% of composition attributable to EBPU. Water contents of SIPN materials ranged from 30% to 70%. SIPNs with ≤15% EBPU of total composition showed little influence to mechanical properties, whereas >15% EBPU contributed significantly to an increase in material stiffness. In the hydrated state, SIPNs with ≤15% EBPU of total composition show little difference in polar component (γp) of surface free energy, whereas for >15% EBPU there is a decrease in γp. The EBPU SIPN hydrogels display complementary material properties for keratoprosthesis, orthokeratology, and mini‐scleral applications. © 2018 The Authors. Journal of Biomedical Materials Research Part B: Applied Biomaterials published by Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B: 1645–1653, 2019.

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The osteo-odonto-keratoprosthesis

Abstract: The osteo-odonto-keratoprosthesis is the procedure of choice for rehabilitation of corneal blindness for end-stage ocular surface disease, serving a completely different patient group to the Boston Type 1 KPro.

Cited by 28 publications

References 23 publications

The Osteo-odonto-keratoprosthesis to restore vision after severe dog bite injury

The Osteo-odonto-keratoprosthesis to restore vision after severe dog bite injury

Keratoprosthesis: Current Choices and Future Development

High modulus hydrogels for ophthalmic and related biomedical applications

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