The orthomolecular treatment of cancer

Cameron, Ewan; Campbell, Allan; Jack, Thomas

doi:10.1016/0009-2797(75)90007-1

Cited by 73 publications

(18 citation statements)

References 5 publications

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“…The value of P (one-tailed) is the area of the standardized normal distribution curve beyond ZV. [5] Effect of Vitamin C. Values of the development of first lesions ofvarious sizes in the groups receiving chow alone or chow [6] plus 0.3%, 5%, or 10% ascorbic acid at each ofthe nine readings…”

Section: Resultsmentioning

confidence: 99%

“…Interest in vitamin C and other dietary factors in relation to the incidence of and mortality from cancer in human beings has been stimulated by the studies of the value of vitamin C for patients with advanced cancer in Vale of Leven Hospital (Loch Lomondside, Scotland) from 1971 on (1)(2)(3)(4)(5)(6)(7)(8)(9). In 1973 it was suggested to one of us (L.P.) that we carry on studies of vitamin C in relation to cancer in animals (8).…”

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confidence: 99%

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Effects of intake of L-ascorbic acid on the incidence of dermal neoplasms induced in mice by ultraviolet light.

Dunham¹,

Zuckerkandl²,

Reynolds³

et al. 1982

Proc. Natl. Acad. Sci. U.S.A.

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We have carried out a study of large malignant skin tumors (squamous cell carcinomas) and other lesions in hairless mice (groups of 38-45) intermittently exposed to ultraviolet light over a period of 15 weeks, beginning when the mice were about 10 weeks old. The several groups were given a standard diet with 0%, 0.3%, 5%, and 10% added L-ascorbic acid (vitamin C) throughout the study. No lesions developed in unirradiated control groups. The lesions were counted every 14 days for 4 months, beginning 4 weeks before the end ofthe period ofirradiation. The observed incidence of lesions of several sizes during successive time periods was analyzed by the statistical method recommended by a committee of the International Agency for Research on Cancer. A pronounced effect of vitamin C in decreasing the incidence and delaying the onset of the malignant lesions was observed with high statistical significance.Interest in vitamin C and other dietary factors in relation to the incidence of and mortality from cancer in human beings has been stimulated by the studies of the value of vitamin C for patients with advanced cancer in Vale of Leven Hospital (Loch Lomondside, Scotland) from 1971 on (1-9). In 1973 it was suggested to one of us (L.P.) that we carry on studies of vitamin C in relation to cancer in animals (8). We began these studies in 1976, and we recently published a report on four studies of vitamin C and vitamin E in relation to skin cancer in hairless mice exposed to ultraviolet light in a standard way (10). In the present paper we report on another study on irradiated mice.About 10 years ago, Homer Black and his collaborators reported that cholesterol-5d,6d-epoxide (cholestan-5d,6d-epoxy-3-ol), a carcinogenic sterol, is formed in skin on ultraviolet irradiation, both in humans (11) and in mice (12, 13). They also reported that dietary anti-oxidants [a mixture ofL-ascorbic acid, butylated hydroxytoluene, D,L-a-tocopheryl acetate (vitamin E), and glutathione] suppressed tumor formation induced in hairless mice by exposure to ultraviolet light (12). Black has given us much information and advice about his techniques. MATERIALS AND METHODSThe hairless mouse is a mutant that loses its hair about 3 weeks after birth, providing easy visibility of skin lesions. It does not have the thymus defect of the nude mutant. Our mice, all females, were of the SK h-hr strain bred at Temple University Health Sciences Center (Philadelphia). They were obtained in March and April of 1980 at age 6-9 weeks. They were maintained for at least 2 weeks on Purina certified rodent chow no.5002 to stabilize the colony before the special diets were begun.They were then distributed five mice to a cage so that the combined weight and mean age per cage were standardized (individual weights, 17.6-32.9 g; ages, 8-11 weeks). Irradiation was begun 10 days later and was continued 5 days per week for about 15 weeks to a total exposure of 135 J/cm2. The radiation was from GE-UA3 mercury arc lamps as described by Black except that an automatic timi...

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Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Effects of intake of L-ascorbic acid on the incidence of dermal neoplasms induced in mice by ultraviolet light.

Dunham¹,

Zuckerkandl²,

Reynolds³

et al. 1982

Proc. Natl. Acad. Sci. U.S.A.

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“…Parenteral administration is needed to reach the 3 to 20 mM blood concentrations necessary to obtain the pro-oxidant function required for therapeutic effect [20]. Although there is some evidence for a therapeutic efficacy of intravenous (IV) ASC, its clinical benefit has remained elusive, and based on single or few case-reports [21–27]. A number of clinical trials are currently ongoing to ascertain the pharmacodynamic properties of IV ASC and its possible role in cancer treatment.…”

Section: Introductionmentioning

confidence: 99%

High-dose ascorbate and arsenic trioxide selectively kill acute myeloid leukemia and acute promyelocytic leukemia blasts in vitro

et al. 2017

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The use of high-dose ascorbate (ASC) for the treatment of human cancer has been attempted several decades ago and has been recently revived by several in vitro and in vivo studies in solid tumors. We tested the cytotoxic effects of ASC, alone or in combination with arsenic trioxide (ATO) in acute myeloid leukemia (AML) and acute promyelocytic leukemia (APL). Leukemic cell lines and primary blasts from AML and APL patients were treated with graded concentrations of ASC, alone or in association with standard concentration (1 μM) of ATO. The ASC/ATO combination killed myeloid blasts, including leukemic CD34+ cells, while sparing CD34+ progenitors obtained from normal cord blood and bone marrow. Actually, approximately one-third (11/36) of primary AML cases were highly sensitive to the ASC/ATO combination. The mechanism of cell killing appeared to be related to increased oxidative stress and overproduction of ROS in a non-quantitative fashion, which resulted in induction of apoptosis. These effects were reverted by the addition of the antioxidant N-Acetyl-Cysteine (NAC). In the APL NB4 model, ASC induced direct degradation of the PML and PML/RARA proteins via caspase activation, while the transcriptional repressor DAXX was recruited in re-constituted PML nuclear bodies. Our findings encourage the design of pilot studies to explore the potential clinical benefit of ASC alone or in combination with ATO in advanced AML and APL.

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“…It was also claimed that vitamin C-treated patients experienced increased feeling of well-being though this claim was not based on specific clinical features (69). Tumor regression was documented in an individual case (70). The critical question then is obviously if the established benefit of conventional chemotherapy can be weighed against a potential benefit from vitamin C for which the omission of conventional chemotherapy would be a prerequisite.…”

Section: A Role Of Vitamins C and E In The Chemotherapy Of Cancer?mentioning

confidence: 99%

The dual role of antioxidants in the modification of chemical carcinogenesis

Kahl¹

1986

Environmental Carcinogenesis Reviews

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The orthomolecular treatment of cancer

Cited by 73 publications

References 5 publications

Effects of intake of L-ascorbic acid on the incidence of dermal neoplasms induced in mice by ultraviolet light.

Effects of intake of L-ascorbic acid on the incidence of dermal neoplasms induced in mice by ultraviolet light.

High-dose ascorbate and arsenic trioxide selectively kill acute myeloid leukemia and acute promyelocytic leukemia blasts in vitro

The dual role of antioxidants in the modification of chemical carcinogenesis

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