2024
DOI: 10.7554/elife.91345
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The ORP9-ORP11 dimer promotes sphingomyelin synthesis

Birol Cabukusta,
Shalom Borst Pauwels,
Jimmy JLL Akkermans
et al.

Abstract: Numerous lipids are heterogeneously distributed among organelles. Most lipid trafficking between organelles is achieved by a group of lipid transfer proteins (LTPs) that carry lipids using their hydrophobic cavities. The human genome encodes many intracellular LTPs responsible for lipid trafficking and the function of many LTPs in defining cellular lipid levels and distributions is unclear. Here, we created a gene knockout library targeting 90 intracellular LTPs and performed whole-cell lipidomics analysis. Th… Show more

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