The origin of the sporadic prion

Damavandi, Pardis Tabaee

doi:10.31220/osf.io/r2kbt

2018

DOI: 10.31220/osf.io/r2kbt

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The origin of the sporadic prion

Pardis Tabaee Damavandi¹

Abstract: This is a perspective.

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“…Stochasticity in synthesis induces growth heterogeneity, which results in mechanical stress and feeds back on synthesis. We use a viscous description of long-term tissue remodeling, so that we cannot account for short-term elastic tissue behavior, which would be better captured by an elastic model as performed in a parallel study (34). Formally, the model describes an expanding, mechanoresponsive, nematic, and active fluid.…”

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Modulation of tissue growth heterogeneity by responses to mechanical stress

Fruleux

Boudaoud

2018

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Morphogenesis often yields organs with robust size and shapes, whereas cell growth and deformation feature significant spatio-temporal variability. Here, we investigate whether tissue responses to mechanical signals contribute to resolve this apparent paradox. We built a model of growing tissues made of fiber-like material, which may account for the cytoskeleton, polar cell-cell adhesion, or the extracellular matrix in animals, and for the cell wall in plants. We considered the synthesis and remodeling of this material, as well as the modulation of synthesis by isotropic and anisotropic response to mechanical stress. Formally, our model describes an expanding, mechanoresponsive, nematic, and active fluid. We show that mechanical responses buffer localized perturbations, with two possible regimes -hypo-responsive and hyper-responsive, and the transition between the two corresponds to a minimum value of the relaxation time. Whereas robustness of shapes suggests that growth fluctuations are confined to small scales, our model yields growth fluctuations that have long-range correlations. This indicates that growth fluctuations are a significant source of heterogeneity in development. Nevertheless, we find that mechanical responses may dampen such fluctuations, with a specific magnitude of anisotropic response that minimizes heterogeneity of tissue contours. We finally discuss how our predictions might apply to the development of plants and animals. Altogether, our results call for the systematic quantification of fluctuations in growing tissues.

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confidence: 99%

Modulation of tissue growth heterogeneity by responses to mechanical stress

Fruleux

Boudaoud

2018

Preprint

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The origin of the sporadic prion

Abstract: This is a perspective.

Cited by 1 publication

References 0 publications

Modulation of tissue growth heterogeneity by responses to mechanical stress

Modulation of tissue growth heterogeneity by responses to mechanical stress

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