The Origin of the Hydroxyl Radical Oxygen in the Fenton Reaction

Lloyd, Roger V.; Hanna, Phillip M.; Mason, Ronald P.

doi:10.1016/s0891-5849(96)00432-7

Cited by 363 publications

(206 citation statements)

References 16 publications

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“…Fenton Weiss reaction is a reaction between ferrous ion and hydrogen peroxide which produces highly reactive hydroxyl radicals implicated in many diseases. 35 The metal chelating effects of the samples were dependent on concentration and linearly increased with the sample concentration increased. The affinity of 3a-i for ferrous ions was relatively low comparison to EDTA (Fig.3).…”

Section: Biologymentioning

confidence: 97%

Schiff bases of 4-(methylthio)benzaldehydes: Synthesis,characterization, antibacterial, antioxidant and cytotoxicity Studies

Karthik¹,

Mallesha²,

Nagashree³

et al. 2016

10.5267/j.ccl

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A series of new Schiff bases of 4-(methylthio)benzaldehyde derivatives 3(a-i) were synthesized by the reaction of 4-(methylthio)benzaldehyde with various amines 2(a-i). Newly synthesized compounds were characterized by elemental analyses, UV-visible, FT-IR, Mass and 1 H NMR spectral studies. All compounds were evaluated for their in vitro antibacterial activity against clinically isolated strains i.e., E. Coli, P. Fluorescence, M. Luteus and B. Subtilis. These compounds were screened for their antioxidant activity by 2,2-diphenyl-1-picryl-hydrazyl (DPPH • ) and ferrous ion chelating assay (Fe 2+ ) methods. The cytotoxicity assay was performed by tryphan blue dye exclusion method. Compounds 3g, 3h and 3i exhibited good antibacterial activity when compared with other compounds in the series against tested pathogenic bacterial strains. All the compounds showed antioxidant activity, where compound 3b was the best radical scavenger and Fe 2+ ion scavenger. These findings showed that the Schiff bases of 4-(methylthio)benzaldehyde derivatives possess antioxidant activity with different mechanism of actions towards the different free radicals tested. Among these derivatives, 3b and 3h had the strongest activity against human peripheral lymphocytes.

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Section: Biologymentioning

confidence: 97%

Schiff bases of 4-(methylthio)benzaldehydes: Synthesis,characterization, antibacterial, antioxidant and cytotoxicity Studies

Karthik¹,

Mallesha²,

Nagashree³

et al. 2016

10.5267/j.ccl

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“…Unfortunately, they contain unpaired electrons that enable them to participate in one-electron transfer reactions. Hence, they are powerful catalysts of autoxidation reactions 14) . Antioxidant factors can be divided into two groups such as scavenging of radicals formed during reaction and inhibiting the radical generation.…”

Section: Discussionmentioning

confidence: 99%

The root extract of Paeonia lactiflora Pall inhibits the oxidative damage via its anti-oxidant activity

Yun¹,

Jeong²,

Park³

et al. 2012

The Korea Journal of Herbology

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Objectives : Reactive oxygen species (ROS) have been associated with pathogenic processes including carcinogenesis through direct effect on DNA directly and by acting as a tumor promoter. Therefore, it has been regarded that ROS may be a major target for cancer prevention. The root of Paeonia lactiflora pall (PL), a traditional Chinese herb, has been a component of effective prescriptions for treatment of liver disease. Also, there are some reports about the antioxidant activities of the extracts from PL. However, little has been known about the effects of PL against oxidative damage. This work aimed to elucidate the anti-oxidant effects of Paeonia lactiflora pall (PL) in the non-cellular system and cellular system. Methods : Antioxidant activities of PL were evaluated by hydroxyl radical scavenging assay and Fe 2+ chelating assay. Anti-oxidative effect of PL was evaluated by φX-174 RF I plasmid DNA cleavage assay in non-cellular system. In addition, DNA migration assay, expression level of phospho-H2AX, MTT assay and lipid peroxidation assay were performed for evaluate the anti-oxidative effect of PL in cellular system. Results : PL had a dose-dependent hydroxyl radical scavenging and Fe 2+ chelating capacity. In addition, PL inhibited oxidative DNA and cell damage induced by hydroxyl radical in non-cellular system and cellular system.Conclusion : Taken together, P. lactiflora pall may be possible for the application to a potential drug for treating the oxidative diseases such as cancer.

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“…[24] The hydroxyl radical (OH -) thus produced may attack the sugar of DNA base causing sugar fragmentation, base loss and DNA strand breakage. [25] In the present study, this hydroxyl radical scavenging activity was shown by all the six bioactive factions [ figure-3(b)].…”

Section: Free Radical Inhibition Activitiesmentioning

confidence: 99%

Phytochemical Screening and ln-vitro Antioxidant Profiling of Solvent Fractions of Canna edulis Ker Gawler

Mishra

Sen

2012

Free Radicals and Antioxidants

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13Fr e e R a d . A n t i ox .Re s e a r c h A r t i c l e West Bengal, apdas.nbu@gmail.com; senarnab_nbu@hotmail.com INTRODUCTIONOxygen plays a vital role in the survival of life on earth. However, during it's utilization in various life processes, a tiny amount of oxygen gets reduced to different free radicals like hydrogen peroxide, superoxide, nitric oxide, hydroxyl radicals etc. [1,2] All these reactive oxygen radicals are accountable for various health hazards to human life causing the development of degenerative diseases.[3] Antioxidant molecules, on the other hand, can slow down or cease the activity of these harmful oxygen species by being oxidizing themselves. Plants often contain good amount of natural antioxidants. [4,5] Different phytochemicals like phenols, flavonols, carotenoids, proanthocyanidins, vitamin C and E can be utilized to scavenge the excess free radicals from human body. [6] Canna edulis Ker Gawler, is a medium sized perennial flowering plant found in the north eastern Himalayan regions of India.[7] The plants bear broad, flat, blackish green leaves with spectacular red flowers. Besides, it also tickles our test buds as it is known to be edible and mainly consumed by the Indian tribes like Lepchas, Bhutias and Nepalis. [8] Different parts of the plants like rhizomes, leaves and seeds are used as medicines by the tribal communities of North eastern India.[9] Amongst various plant parts the extracts of rhizomes are rich source of polyphenolic compounds like phenols and flavonoids, [10] which in turn provide the evidences of antioxidative properties of the plant. ABSTRACT Introduction:Canna edulis Ker Gawler, grown in the sub Himalayan region containing starchy rhizome are used by the tribal people as food and herbal medicine. Methods: Investigations were done to find out 2,2-diphenyl-1-picryl hydrazyl (DPPH) radical scavenging activity, total flavonols and total proanthocyanidin contents, nitric oxide (NO) scavenging activity, hydroxyl radical scavenging activity of different solvent fractions of aquous extract of C. edulis rhizome. Among the cellular molecules, lipids containing unsaturated fatty acids with more than one double bond are particularly susceptible to action of free radicals. The resulting reaction, known as lipid peroxidation and anti lipid peroxidation activity has been performed using goat liver homogenate. Results: Six out of 29 fractions showed DPPH free radical inhibition above 75% and were used for further phytochemical screening. Diethyl ether : ethyl acetate (1:3) fraction showed the maximum inhibition percent. Highest amount of total flavonol and total proanthocyanidins were recorded in diethyl ether : ethyl acetate (1:3) fraction. Maximum NO scavenging activity and hydroxyl radical inhibition activity were observed in bioactive diethyl ether : ethyl acetate (1:1) fraction. Inhibition of lipid peroxides was maximum in ethyl acetate fraction. Data from thin layer chromatography (TLC) revealed the presence of phenolic compounds in all fractions, whereas flavono...

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The Origin of the Hydroxyl Radical Oxygen in the Fenton Reaction

Cited by 363 publications

References 16 publications

Schiff bases of 4-(methylthio)benzaldehydes: Synthesis,characterization, antibacterial, antioxidant and cytotoxicity Studies

Schiff bases of 4-(methylthio)benzaldehydes: Synthesis,characterization, antibacterial, antioxidant and cytotoxicity Studies

The root extract of Paeonia lactiflora Pall inhibits the oxidative damage via its anti-oxidant activity

Phytochemical Screening and ln-vitro Antioxidant Profiling of Solvent Fractions of Canna edulis Ker Gawler

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