The origin of intrinsic ganglia of trunk viscera from vagal neural crest in the chick embryo

Yntema, C. L.; Hammond, Warner S.

doi:10.1002/cne.901010212

Cited by 411 publications

(205 citation statements)

References 18 publications

Supporting

Mentioning

189

Contrasting

Unclassified

Order By: Relevance

“…This could mean that the vagal neural crest, which gives rise to enteric ganglia along the entire digestive tract in quail-chick chimeras (Le Douarin and Teillet, 1973), may not be the only source for enteric ganglia in the foregut. Yntema and Hammond (1954) described aganglionosis of the entire digestive tract after ablation of the vagal neural crest. This was only the case, however, when the ablation included the anterior rhombencephalic neural crest from the otic vesicle up to the level of the fifth cranial nerve (corre- sponding to rhombomere 2).…”

Section: Discussion Regional Differences Within the Vagal Neural Cresmentioning

confidence: 99%

Ablation of various regions within the avian vagal neural crest has differential effects on ganglion formation in the fore‐, mid‐ and hindgut

Sanden¹,

Kirby

Groot

et al. 1993

Developmental Dynamics

View full text Add to dashboard Cite

The vagal neural crest adjacent to the first seven somites gives rise to both ganglionic and ectomesenchymal derivatives. Ganglionic derivatives are the neurons and supportive cells of the enteric nervous system (ENS), cardiac, and dorsal root ganglia. Ectomesenchymal derivatives are cells in the cardiac outflow tract and the mesenchymal components of thymus and parathyroids. Ectomesenchymal derivatives are formed by a segment of the vagal neural crest, from the level of the otic vesicle down to the caudal boundary of the third somite, called the cardiac neural crest. We performed neural crest ablations to study regional differences within the avian vagal neural crest with regard to the formation of the ENS. Ablation of the entire vagal neural crest from the mid-otic vesicle down to the seventh somite plus the nodose placode resulted in the absence of ganglia in the midgut (jejunum and ileum) and hindgut (colon). The foregut (esophagus, proventriculus, gizzard, and duodenum) was normally innervated. After ablation of the vagal neural crest adjacent to somites 3-5, ganglia were absent in the hindgut. Ablations of vagal neural crest not including this segment had no effect on the formation of the ENS. We surmise that the innervation of the hindgut in vivo depends specifically on the neural crest adjacent to somites 3-5, whereas innervation of the midgut can be accomplished by all segments within the vagal neural crest. The foregut can also be innervated by a source outside the vagal neural crest.To study intrinsic differences between various vagal neural crest segments regarding ENS formation, we performed chorioallantoic membrane cocultures of segments of quail vagal neural anlage and E4 chicken hindgut. We found that all vagal neural crest segments were able to give rise to enteric ganglia in the hindgut. When the neural crest of somites 6 and 7 was included in the segment, we also found melanocytes in the hindgut, suggesting that this segment is more related to trunk neural crest. Furthermore, we found that the vagal neural anlage from older embryos (>18 somites) showed an increased potential to form enteric ganglia. This suggests that vagal neural crest cells that have been in prolonged contact with the neural tube in vivo, because of either late emigration or delayed migration, have an increased probability to form enteric ganglia.0 1993 Wiley-Liss, Inc.

show abstract

Section: Discussion Regional Differences Within the Vagal Neural Cresmentioning

confidence: 99%

Ablation of various regions within the avian vagal neural crest has differential effects on ganglion formation in the fore‐, mid‐ and hindgut

Sanden¹,

Kirby

Groot

et al. 1993

Developmental Dynamics

View full text Add to dashboard Cite

show abstract

“…They are induced along the entire length of neuraxis as a bilateral, segmented stripe of cells at the lateral border of the neural plate and nonneural ectoderm (Hall, 2008;Le Douarin and Kalcheim, 1999;Sauka-Spengler and Bronner-Fraser, 2008;Steventon et al, 2005). NC cells are subdivided into cranial (Graham et al, 2004;Cordero et al, 2011), cardiac (Kirby et al, 1983;Keyte and Hutson, 2012), vagal (Kuo and Erickson, 2011;Peters-Van Der Sanden et al, 1993;Burns and Le Douarin, 1998;Yntema and Hammond, 1954), trunk (Bronner-Fraser and Fraser, 1989;Serbedzija et al, 1994) and sacral (Burns and Le Douarin, 1998;Anderson et al, 2006) NC cells due to their diversity along neuraxis ( Fig.1.1A). Upon closure of the neural plate, NC cells undergo epithelial-to-mesenchymal transition (EMT) (Ahlstrom and Erickson, 2009;Alfandari et al, 2010;Berndt et al, 2008 andDuband, 2010) allowing them to delaminate from prospective neural tube and migrate throughout the embryo ( Fig.1.1B).…”

Section: An Overview Of Nc Cell Development and The Importance Of Nc mentioning

confidence: 99%

Controlled levels of canonical Wnt signaling are required for neural crest migration

Maj

Künneke

Loresch

et al. 2016

Developmental Biology

View full text Add to dashboard Cite

“…Although the ablation experiments of Yntema and Hammond (1954) had shown the importance of the vagal crest to the formation of the enteric nervous system, the orthotopic grafting studies of LeDouarin and Teillet (1973) first demonstrated the extent of the vagal crest which entered the gut. These authors transplanted 5 somite lengths of quail neural tube into chick hosts and concluded that the crest cells between somites 1-7 colonized the gut.…”

Section: Introductionmentioning

confidence: 99%

Mapping the origin of the avian enteric nervous system with a retroviral marker

Epstein

Matsukawa

Brown

et al. 1994

Developmental Dynamics

View full text Add to dashboard Cite

The enteric nervous system is largely formed from the vagal neural crest which arises from the neuroaxis between somites 1-7. In order to evaluate the contribution of different regions of the vagal crest to the enteric nervous system, we marked crest cells by injecting somites 1-10 with a replication-defective spleen necrosis virus vector which contains the marker gene ZucZ. After incubation in X-gal, ZucZ-positive blue cells were found in the wall of the gut in three locations. Most were found at the peripheral edge of the developing circular muscle and within the developing submucosa, sites characteristic of developing ganglia. LacZ-positive cells in these ganglionic sites were always surrounded by HNK-1 immunostained cells, confirming their neural crest origin. LucZ-positive cells were also seen in a third location, the circular muscle layer of the esophagus and crop, and were separated from the HNK-1 positive ganglionic elements. These cells in the circular muscle are probably muscle cells derived from labeled mesodermal cells of the somite. Injection of somites 3, 4, 5, and 6 resulted in the largest percentage of preparations with ZucZ-positive crest-derived cells and in the largest number of positive cells in the gut. After injection of these somites, ZacZpositive crest-derived cells were found in all regions of the gut from the proventriculus to the rectum. Very few positive crest-derived cells were found in the esophagus. Injection of somites 1, 2, and 7 resulted in a smaller percentage of preparations with positive crest-derived cells and in a smaller number of positive crest-derived cells, which were confined to the fore and midgut. The gizzard was the gut region most frequently containing labeled cells and the rectum was the region least frequently containing such cells. This suggests that the number of crest cells available for colonization of the gut decreases as the distance from the gizzard increases. We conclude that the region of the neuroaxis between somites 3-6 is the major source of crest cells to the gut and that crest cells from different segments of the neuroaxis do not appear to be segregated to different regions of the gut.

show abstract

The origin of intrinsic ganglia of trunk viscera from vagal neural crest in the chick embryo

Cited by 411 publications

References 18 publications

Ablation of various regions within the avian vagal neural crest has differential effects on ganglion formation in the fore‐, mid‐ and hindgut

Ablation of various regions within the avian vagal neural crest has differential effects on ganglion formation in the fore‐, mid‐ and hindgut

Controlled levels of canonical Wnt signaling are required for neural crest migration

Mapping the origin of the avian enteric nervous system with a retroviral marker

Contact Info

Product

Resources

About