2017
DOI: 10.1016/j.devcel.2017.09.016
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The Origin of Animal Multicellularity and Cell Differentiation

Abstract: Over 600 million years ago, animals evolved from a unicellular or colonial organism whose cell(s) captured bacteria with a collar complex, a flagellum surrounded by a microvillar collar. Using principles from evolutionary cell biology, we reason that the transition to multicellularity required modification of pre-existing mechanisms for extracellular matrix synthesis and cytokinesis. We discuss two hypotheses for the origin of animal cell types: division of labor from ancient plurifunctional cells and conversi… Show more

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Cited by 315 publications
(447 citation statements)
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References 184 publications
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“…This might be a key question in attempts to decipher the onset of phytoplankton aggregates; do individual cells converge or do cells undergo clonal divisions while attached? Both modes of multicellularlike assemblages occur in various microorganisms including choanoflagellates, ciliates, fungi, amoeba, and more (Brunet and King, 2017). Aggregation and clonal division are considered to be ancestral forms of current complex multicellularity, with clonal development being ancestral to all forms (Brunet and King, 2017).…”
Section: Resultsmentioning
confidence: 99%
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“…This might be a key question in attempts to decipher the onset of phytoplankton aggregates; do individual cells converge or do cells undergo clonal divisions while attached? Both modes of multicellularlike assemblages occur in various microorganisms including choanoflagellates, ciliates, fungi, amoeba, and more (Brunet and King, 2017). Aggregation and clonal division are considered to be ancestral forms of current complex multicellularity, with clonal development being ancestral to all forms (Brunet and King, 2017).…”
Section: Resultsmentioning
confidence: 99%
“…Interestingly, many genes that are necessary for animal multicellularity are involved in cell-cell adhesion and have evolved prior to animal origins (Brunet and King, 2017). Furthermore, clumping has been used as a trait to experimentally evolve multicellularity in yeast and algae (Ratcliff et al, 2012(Ratcliff et al, , 2013Driscoll and Travisano, 2017).…”
Section: Phytoplankton Cell-cell Adhesionmentioning
confidence: 99%
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“…These unicellular opisthokonts are understudied compared to their multicellular relatives, even though they are essential for better understanding key evolutionary transitions, including those that took place at the origins of both animals and fungi (Ruiz-Trillo et al, 2007;Richter and King, 2013;Brunet and King, 2017;Richards et al, 2017;Sebé-Pedrós et al, 2017).…”
Section: Introductionmentioning
confidence: 99%