The Origin and Molecular Epidemiology of Dengue Fever in Hainan Province, China, 2019

Abstract

There was an outbreak of Dengue fever on September 5, 2019, in Hainan Province, which has not been endemic for 28 years. We aim to describe the clinical and epidemiological features of the 2019 outbreak in Hainan Province and identify the cause. All type 1 Dengue fever cases that occurred in this outbreak of Hainan exhibited mild clinical symptoms. The epidemiological investigations indicate that the outbreak might originate from workers in the Xiuying area, Haikou City, form a concentrated outbreak, and then spread out. Bayesian phylogenies results and epidemiological data were used to infer a likely series of events for the dengue virus’s potential spread and trace the possible sources. The strains’ sequences were close to a sequence from the nearby Guangdong province, supporting the hypothesis that the dengue virus was imported from Guangdong province and then spread across Hainan province. Furthermore, it is interesting that two other strains didn’t group with this cluster, suggesting that additional introduction pathways might exist. The study indicated that the dengue fever epidemic presented two important modes in Hainan. Firstly, epidemics prevalence was caused by imported cases, and then endogenous epidemics broke out in the natural epidemic focus.

Spatio-temporal evolution and trend prediction of the incidence of Class B notifiable infectious diseases in China: a sample of statistical data from 2007 to 2020

“…This indicates that we have achieved notable results in the prevention and control of infectious diseases in China, which is consistent with the results of previous studies [43]. According to the research analysis, the fact that the four provinces have not seen a decline in the incidence of Class B notifiable infectious diseases may be mainly related to their special geographical location and climatic conditions [44][45][46][47][48][49]. In spite of a certain economic boost in Tibet, a border region in the southwest, the increasing trade flows results in the bigger size of the mobile population, which leads to the problem of new and traditional infectious diseases and their increasingly prominent crossborder transmission.…”

Contributions of single-particle cryoelectron microscopy toward fighting COVID-19

“…Although the methods for cryopreparation of sample and computational methods for data analysis and reconstruction go back all the way to the 1980s, atomic resolution could not be achieved for asymmetric structures until the development of novel single-electron-detecting cameras [3][4][5] and their commercial introduction in 2012. It is fortuitous [6], in hindsight, that the technique was ready in time to help in the combat against several viruses implicated in recent deadly epidemics -Ebola (2014-2016) [7][8][9], Zika (2015-2016) [10,11], dengue (2019-2020) [12][13][14][15][16], MERS-CoV (2012-2015) [17][18][19][20], and now SARS-CoV-2.…”

Efektifitas Aplikasi Kobotoolbox terhadap Peningkatan Pengetahuan Petugas Surveilans Demam Berdarah Dengue

“…Dampak dari epidemi terkait demam berdarah menghadirkan dua modus yaitu prevalensi epidemi disebabkan kasus impor dan epidemi endogen yang muncul sebagai fokus epidemi alamiah penyakit (17). Upaya skrining penting dalam menanggulangi kasus khususnya import (18).…”