The origin and evolution of eucaryal HIS7 genes: from metabolon to bifunctional proteins?

Brilli, Matteo; Fani, Renato

doi:10.1016/j.gene.2004.06.033

Cited by 20 publications

(22 citation statements)

References 36 publications

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“…Filamentation, as well as the other pleiotropic effects associated with his overexpression, was shown to occur in E. coli and S. typhimurium strains because of interrupting the carbon flow through the histidine and purine pathways in his pur double mutants (Frandsen and D'Ari, 1993). It has been also suggested (Fani et al, 2005) that proteins encoded by the four genes hisBHAF might interact to form a metabolon (Brilli and Fani, 2004b;Srere, 1987), that is a complex constituted by (transiently) interacting proteins that can facilitate the catalysis of reactions by producing intermediates in the proximity of enzymes that act upon them. This idea is in agreement with the notion that genes coding for proteins that have to interact to form an active complex very often are clustered in conserved operons (Tamames, 2001).…”

Section: Discussionmentioning

confidence: 99%

Structural, evolutionary and genetic analysis of the histidine biosynthetic “core” in the genus Burkholderia

Papaleo

Russo

Fondi

et al. 2009

Gene

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Section: Discussionmentioning

confidence: 99%

Structural, evolutionary and genetic analysis of the histidine biosynthetic “core” in the genus Burkholderia

Papaleo

Russo

Fondi

et al. 2009

Gene

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“…In addition, it was found that some proteins were endowed with more than one catalytic function in a single polypeptide chain (80). These multifunctional proteins are widespread among organisms ranging from bacteria to mammals (12,22,29,68,108), and usually their different activities remain limited to the realm of metabolism. In many cases, it has been demonstrated that the dual function resulted from the fusion of two genes that initially encoded proteins with single functions (12,22,29).…”

Section: Introductionmentioning

confidence: 99%

“…These multifunctional proteins are widespread among organisms ranging from bacteria to mammals (12,22,29,68,108), and usually their different activities remain limited to the realm of metabolism. In many cases, it has been demonstrated that the dual function resulted from the fusion of two genes that initially encoded proteins with single functions (12,22,29). Later on, new results uncovered the surprising fact that a significant number of proteins could perform apparently disparate functions; for example, phosphoglucose isomerase can act as an autocrine motility factor (58), aconitase can act as an iron-responsive element binding protein (79) or as a determinant of mitochondrial DNA stability (27), and glyceraldehyde-3-phosphate dehydrogenase participates in apoptosis and neurodegeneration (125).…”

Section: Introductionmentioning

confidence: 99%

Moonlighting Proteins in Yeasts

Gancedo

Flores

2008

Microbiol Mol Biol Rev

149

123

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SUMMARY Proteins able to participate in unrelated biological processes have been grouped under the generic name of moonlighting proteins. Work with different yeast species has uncovered a great number of moonlighting proteins and shown their importance for adequate functioning of the yeast cell. Moonlighting activities in yeasts include such diverse functions as control of gene expression, organelle assembly, and modification of the activity of metabolic pathways. In this review, we consider several well-studied moonlighting proteins in different yeast species, paying attention to the experimental approaches used to identify them and the evidence that supports their participation in the unexpected function. Usually, moonlighting activities have been uncovered unexpectedly, and up to now, no satisfactory way to predict moonlighting activities has been found. Among the well-characterized moonlighting proteins in yeasts, enzymes from the glycolytic pathway appear to be prominent. For some cases, it is shown that despite close phylogenetic relationships, moonlighting activities are not necessarily conserved among yeast species. Organisms may utilize moonlighting to add a new layer of regulation to conventional regulatory networks. The existence of this type of proteins in yeasts should be taken into account when designing mutant screens or in attempts to model or modify yeast metabolism.

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“…Both of these classes have been shown to play important roles across a wide range of taxa, from vertebrates (1, 2) to bacteria (3,4), and their relative importance has been the topic of considerable discussion (5)(6)(7)(8)(9)(10)(11)(12). Significantly, many previous studies have addressed these questions by focusing on single instances of functional innovation (13)(14)(15)(16) or selective regimes (17)(18)(19)(20)(21)(22). However, to identify general principles, it is necessary to study evolutionary innovation for a large number of different functions in parallel.…”

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confidence: 99%

The predictability of molecular evolution during functional innovation

Blank

Wolf

Ackermann

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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Determining the molecular changes that give rise to functional innovations is a major unresolved problem in biology. The paucity of examples has served as a significant hindrance in furthering our understanding of this process. Here we used experimental evolution with the bacterium Escherichia coli to quantify the molecular changes underlying functional innovation in 68 independent instances ranging over 22 different metabolic functions. Using whole-genome sequencing, we show that the relative contribution of regulatory and structural mutations depends on the cellular context of the metabolic function. In addition, we find that regulatory mutations affect genes that act in pathways relevant to the novel function, whereas structural mutations affect genes that act in unrelated pathways. Finally, we use population genetic modeling to show that the relative contributions of regulatory and structural mutations during functional innovation may be affected by population size. These results provide a predictive framework for the molecular basis of evolutionary innovation, which is essential for anticipating future evolutionary trajectories in the face of rapid environmental change.adaptation | transcription | compensatory mutation | biosynthesis O ne of the most important questions in evolutionary biology concerns the molecular mechanisms that underlie functional innovations. These changes are often polarized into two classes: those that affect protein structure and those that affect protein expression level. Both of these classes have been shown to play important roles across a wide range of taxa, from vertebrates (1, 2) to bacteria (3, 4), and their relative importance has been the topic of considerable discussion (5-12). Significantly, many previous studies have addressed these questions by focusing on single instances of functional innovation (13-16) or selective regimes (17)(18)(19)(20)(21)(22). However, to identify general principles, it is necessary to study evolutionary innovation for a large number of different functions in parallel. Indeed, the fact that only a small number of examples exist has resulted in few hypotheses being put forth that identify general characteristics of the molecular changes underlying functional innovation. One prominent hypothesis states that if the development of a novel trait is spatially or temporally limited, then innovation frequently occurs through changes in regulation (23,24). Whether there are general patterns beyond this is not well-established.Here we used an experimental system that allows the analysis of a large number of independent cases of evolutionary innovation and investigation of the underlying genetic changes. We worked with a collection of 87 strains of Escherichia coli that each had a deletion of one gene encoding a different metabolic function (SI Appendix, Table S1). Each of these deletions resulted in an inability to grow in minimal glucose media. Then, for each of these 87 deleted metabolic functions, we used experimental evolution to select for novel func...

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The origin and evolution of eucaryal HIS7 genes: from metabolon to bifunctional proteins?

Cited by 20 publications

References 36 publications

Structural, evolutionary and genetic analysis of the histidine biosynthetic “core” in the genus Burkholderia

Structural, evolutionary and genetic analysis of the histidine biosynthetic “core” in the genus Burkholderia

Moonlighting Proteins in Yeasts

The predictability of molecular evolution during functional innovation

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