The origin and distribution of the main oxygen sensing mechanism across metazoans

Song, Bing; Modjewski, Luca David; Kapust, Nils; Mizrahi, Itzhak; Martin, William

doi:10.3389/fphys.2022.977391

Cited by 3 publications

(1 citation statement)

References 81 publications

(108 reference statements)

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“…HIF and the regulatory network that regulates oxygen-sensitive degradation are conserved and expressed in widely divergent metazoans [12]. HIF and its regulatory system are simplified in the nematode C. elegans, and this provides opportunities to interrogate this pathway through genetic analyses [13].…”

Section: Introductionmentioning

confidence: 99%

Transcriptome analyses describe the consequences of persistent HIF-1 over-activation in Caenorhabditis elegans

Feng,

Qu,

Powell-Coffman

2024

PLoS ONE

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Metazoan animals rely on oxygen for survival, but during normal development and homeostasis, animals are often challenged by hypoxia (low oxygen). In metazoans, many of the critical hypoxia responses are mediated by the evolutionarily conserved hypoxia-inducible transcription factors (HIFs). The stability and activity of HIF complexes are strictly regulated. In the model organism C. elegans, HIF-1 stability and activity are negatively regulated by VHL-1, EGL-9, RHY-1 and SWAN-1. Importantly, C. elegans mutants carrying strong loss-of-function mutations in these genes are viable, and this provides opportunities to interrogate the molecular consequences of persistent HIF-1 over-activation. We find that the genome-wide gene expression patterns are compellingly similar in these mutants, supporting models in which RHY-1, VHL-1 and EGL-9 function in common pathway(s) to regulate HIF-1 activity. These studies illuminate the diversified biological roles played by HIF-1, including metabolism and stress response. Genes regulated by persistent HIF-1 over-activation overlap with genes responsive to pathogens, and they overlap with genes regulated by DAF-16. As crucial stress regulators, HIF-1 and DAF-16 converge on key stress-responsive genes and function synergistically to enable hypoxia survival.

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Section: Introductionmentioning

confidence: 99%

Transcriptome analyses describe the consequences of persistent HIF-1 over-activation in Caenorhabditis elegans

Feng,

Qu,

Powell-Coffman

2024

PLoS ONE

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show abstract

A gene for all seasons: The evolutionary consequences of HIF-1 in carcinogenesis, tumor growth and metastasis

Bhattacharya,

Brown,

Gatenby

et al. 2024

Seminars in Cancer Biology

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Transcriptome analyses describe the consequences of persistent HIF-1 over-activation inCaenorhabditis elegans

Feng,

2023

Preprint

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Metazoan animals rely on oxygen for survival, but during normal development and homeostasis, animals are often challenged by hypoxia (low oxygen). In metazoans, many of the critical hypoxia responses are mediated by the evolutionarily conserved hypoxia-inducible transcription factors (HIFs). The stability and activity of HIF complexes are strictly regulated. In the model organismC. elegans, HIF-1 stability and activity are negatively regulated by VHL-1, EGL-9, RHY-1 and SWAN-1. Importantly,C. elegansmutants carrying strong loss-of-function mutations in these genes are viable, and this provides opportunities to interrogate the molecular consequences of persistent HIF-1 over-activation. We find that the genome-wide gene expression patterns are compellingly similar in these mutants, supporting models in which RHY-1, SWAN-1 and EGL-9 function in common pathway(s) to regulate HIF-1 activity. These studies illuminate the diversified biological roles played by HIF-1, including metabolism, hypoxia and other stress responses, reproduction and development. Genes regulated by persistent HIF-1 over-activation overlap with genes responsive to pathogens, and they overlap with genes regulated by DAF-16. As crucial stress regulators, HIF-1 and DAF-16 converge on key stress-responsive genes and function synergistically to enable hypoxia survival.

show abstract

The origin and distribution of the main oxygen sensing mechanism across metazoans

Cited by 3 publications

References 81 publications

Transcriptome analyses describe the consequences of persistent HIF-1 over-activation in Caenorhabditis elegans

Transcriptome analyses describe the consequences of persistent HIF-1 over-activation in Caenorhabditis elegans

A gene for all seasons: The evolutionary consequences of HIF-1 in carcinogenesis, tumor growth and metastasis

Transcriptome analyses describe the consequences of persistent HIF-1 over-activation inCaenorhabditis elegans

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