2004
DOI: 10.1261/rna.7105504
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The organization and evolution of the Dipteran and Hymenopteran Down syndrome cell adhesion molecule (Dscam) genes

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Cited by 96 publications
(102 citation statements)
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References 17 publications
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“…This is best demonstrated by genes in arthropods that contain both multiple MXE clusters (“multi‐cluster”) and large clusters with up to 53 MXEs such as in the Drosophila Dscam genes (Graveley et al , 2004; Pillmann et al , 2011). This is in strong contrast to mutually exclusive splicing in vertebrates as there is to date no evidence of multi‐cluster or higher order MXE clusters (Matlin et al , 2005; Pan et al , 2008; Wang et al , 2008; Gerstein et al , 2014; Abascal et al , 2015a,b).…”
Section: Resultsmentioning
confidence: 99%
“…This is best demonstrated by genes in arthropods that contain both multiple MXE clusters (“multi‐cluster”) and large clusters with up to 53 MXEs such as in the Drosophila Dscam genes (Graveley et al , 2004; Pillmann et al , 2011). This is in strong contrast to mutually exclusive splicing in vertebrates as there is to date no evidence of multi‐cluster or higher order MXE clusters (Matlin et al , 2005; Pan et al , 2008; Wang et al , 2008; Gerstein et al , 2014; Abascal et al , 2015a,b).…”
Section: Resultsmentioning
confidence: 99%
“…Recent studies in mammals have shown that a surprisingly large number of alternative exons are species specific. Additionally, there are some alternatively spliced exons that are specific to D. melanogaster or D. pseudoobscura (Graveley et al 2004). Nonetheless, there are numerous alternative exons that are highly conserved between related species.…”
Section: Computational Prediction Of Alternative Exonsmentioning
confidence: 99%
“…Each locus has many alleles that yield high levels of protein diversity among individuals. In insects, a novel system exists for generating immune diversity using the Down syndrome cell adhesion molecule (Dscam) gene, which also encodes Ig domains (12)(13)(14). Dscam is a single-copy locus in which 4 of the 24 exons exhibit substantial duplication that results in differential exon arrays.…”
mentioning
confidence: 99%