Abstract:The increasing size of the transplant waiting list and the increasing use of expanded criteria donors places a premium on efficient use of recovered organs. Maximal organ utilization often necessitates organ sharing between transplant organizations. Optimal organ sharing requires rapid, integrated communication of donor information combined with expedited organ transportation. For more than 20 years, the United Network for Organ Sharing's Organ Center has fulfilled this task for the United States transplant co… Show more
“…Two advances fostered growth of cooperative efforts of transplant centers to exchange kidneys more widely: the advancement of better preservation methods through the development of better preservation solutions and new advances in tissue typing. 32 In the early 1960s, before the development of these solutions, human deceased donor kidneys were preserved by surface cooling or by flushing with extracellular solutions such as Ringer lactate solution with added albumin. Collins and Sacks solutions proved to be much more effective in kidney preservation and permitted sharing of kidneys between transplant centers.…”
The historical development of deceased organ donation, transplantation, and organ procurement organizations is reviewed. The concept of transplantation, taking parts from one animal or person and putting them into another animal or person, is ancient. The development of organ transplantation brought on the need for a source of organs. Although many early kidney transplants used kidneys from living donors, these donors could not satisfy the ever-growing need for organs, and extrarenal organs were recovered only from deceased donors. This need for organs to satisfy the great demand led to specialized organizations to identify deceased donors, manage them until recovery occurred, and to notify transplant centers that organs were available for their patients. The functions of these organ procurement organizations expanded to include other required functions such as education, accounting, and compliance with state and federal requirements. Because of the shortage of organs relative to the demand, lack of a unified organ allocation system, the perception that organs are a national resource and should be governed by national regulations, and to improve results of organ procurement organizations and transplant centers, the federal government has regulated virtually all phases of organ procurement and transplantation.
“…Two advances fostered growth of cooperative efforts of transplant centers to exchange kidneys more widely: the advancement of better preservation methods through the development of better preservation solutions and new advances in tissue typing. 32 In the early 1960s, before the development of these solutions, human deceased donor kidneys were preserved by surface cooling or by flushing with extracellular solutions such as Ringer lactate solution with added albumin. Collins and Sacks solutions proved to be much more effective in kidney preservation and permitted sharing of kidneys between transplant centers.…”
The historical development of deceased organ donation, transplantation, and organ procurement organizations is reviewed. The concept of transplantation, taking parts from one animal or person and putting them into another animal or person, is ancient. The development of organ transplantation brought on the need for a source of organs. Although many early kidney transplants used kidneys from living donors, these donors could not satisfy the ever-growing need for organs, and extrarenal organs were recovered only from deceased donors. This need for organs to satisfy the great demand led to specialized organizations to identify deceased donors, manage them until recovery occurred, and to notify transplant centers that organs were available for their patients. The functions of these organ procurement organizations expanded to include other required functions such as education, accounting, and compliance with state and federal requirements. Because of the shortage of organs relative to the demand, lack of a unified organ allocation system, the perception that organs are a national resource and should be governed by national regulations, and to improve results of organ procurement organizations and transplant centers, the federal government has regulated virtually all phases of organ procurement and transplantation.
“…The allocation of organs has evolved significantly over time and has been facilitated by the United Network for Organ Sharing (UNOS) to promote equitable sharing . To accomplish this, UNOS created 11 regions, each with a significant number of transplantation centers, to maximize geographic limitations based upon organ ischemia time of <4 hours. Over the last 20 years, UNOS has created algorithms and implemented policies to align provisions of transplantation with clinical severity .…”
Background
The number of heart transplants performed is limited by organ availability and is managed by the United Network for Organ Sharing (UNOS). Efforts are underway to make organ disbursement more equitable as demand increases.
Hypothesis
Significant variation exists in contemporary patterns of care, wait times, and outcomes among patients undergoing heart transplantation across UNOS regions.
Methods
We identified adult patients undergoing first, single‐organ heart transplantation between January 2006 and December 2014 in the UNOS dataset and compared sociodemographic and clinical profiles, wait times, use of mechanical circulatory support (MCS), status at time of transplantation, and 1‐year survival across UNOS regions.
Results
We analyzed 17 096 patients undergoing heart transplantation. There were no differences in age, sex, renal function, and peripheral vascular resistance across regions; however, there was 3‐fold variation in median wait time (range, 48–166 days) across UNOS regions. Proportion of patients undergoing transplantation with status 1A ranged from 36% to 79% across regions (P < 0.01), and percentage of patients hospitalized at time of transplantation varied from 41% to 98%. There was also marked variation in MCS and inotrope utilization (28%–57% and 25%–58%, respectively; P < 0.001). Durable ventricular assist device implantation varied from 20% to 44% (P < 0.001), and intra‐aortic balloon pump utilization ranged from 4% to 18%.
Conclusions
Marked differences exist in patterns of care across UNOS regions that generally trend with differences in waitlist time. Novel policy initiatives are required to address disparities in access to allografts and ensure equitable and efficient allocation of organs.
“…the transplant candidate waiting list and organ-matching system that comprises UNet and DonorNet. 1 Available 24 hours a day, 365 days a year, the Organ Center assists the US transplant community by…”
mentioning
confidence: 99%
“…• Running and transmitting the computerized donor/recipient match results 1 The Organ Center is staffed by 17 full-time organ placement specialists, 1 data and operations specialist, and 3 managers. The Organ Center workday is divided into two 12-hour shifts and is typically staffed with 3 organ placement specialists per shift and 1 additional organ placement specialist on call.…”
One of the goals of the Organ Center of the Organ Procurement and Transplantation Network/United Network for Organ Sharing is to increase the efficiency of equitable organ allocation in the United States. Recognizing the ever-growing need for organ donors and transplants, leaders at the Organ Center increased its commitment to quality improvement initiatives through the development of a quality management team in 2001. The Organ Center began to focus on ways to capture data on processes and pinpoint areas for improvement. As the collection and analysis of data evolved, the Organ Center embraced formal quality standards, such as improvement cycles. Using these cycles, the Organ Center has seen significant improvement. One initiative involving lifesaving heart, lung, and liver placement showed success by doubling the Organ Center's organ placement rate. Another project involving the validation of donor information demonstrated that the accuracy of organ allocation can be improved by 5% on a consistent basis. As stewards for the gift of life and leaders in organ allocation, the Organ Center uses continuous quality improvement to achieve the goal of increasing the efficiency of equitable organ allocation.
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