The orexinergic system mediates the excitatory effects of caffeine on the arousal and sympathetic activity

Li, Yan; Guo, Ziyue; Cai, Chenxi; Liu, Danni; Kang, Y. James; Liu, Pengfei

doi:10.1016/j.heliyon.2023.e14170

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Acetylcholine(ach)1

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2024

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“…Caffeine is renowned for its wake-promoting effect by inhibiting adenosine activity via adenosine receptor antagonism [30]. However, a recent study also reported that Caffeine could excite orexin activity [31]. Depletion of Hcrt neurons is also a major cause of Narcolepsy, a neurological disorder characterized by sudden, involuntary sleep during the day and excessive daytime sleepiness.…”

Section: Acetylcholine(ach)mentioning

confidence: 99%

The neurotransmitters of sleep and arousal

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2024

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The sleep and arousal, or the vigilance state, is controlled by a highly dynamic brain system that involves numerous interconnected brain circuits. However, while many reviews presented the anatomical bases of how different components of the brain area contribute to the vigilance states, less attention is paid from the perspective of different neurotransmitters. As multiple different neuronal populations could exist and express in the same brain area, attributing the effect of different brain areas on sleep and arousal would not be precise without consideration of the act of neurotransmitters. This review summarizes the recent progress on how different neurotransmitters affect vigilance states. By doing so, this review aims to provide an alternative angle in understanding how different vigilance state is regulated by the brain.

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Section: Acetylcholine(ach)mentioning

confidence: 99%

The neurotransmitters of sleep and arousal

Fan

2024

TNS

View full text Add to dashboard Cite

show abstract

The orexinergic system mediates the excitatory effects of caffeine on the arousal and sympathetic activity

Cited by 1 publication

References 32 publications

The neurotransmitters of sleep and arousal

The neurotransmitters of sleep and arousal

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