We propose a class of toric Lagrangian A-branes on the resolved conifold that is suitable to describe torus knots on S 3 . The key role is played by the SL(2, Z) transformation, which generates a general torus knot from the unknot. Applying the topological vertex to the proposed A-branes, we rederive the colored HOMFLY polynomials for torus knots, in agreement with the Rosso and Jones formula. We show that our A-model construction is mirror symmetric to the B-model analysis of Brini, Eynard and Mariño. Comparing to the recent proposal by Aganagic and Vafa for knots on S 3 , we demonstrate that the disk amplitude of the A-brane associated to any knot is sufficient to reconstruct the entire Bmodel spectral curve. Finally, the construction of toric Lagrangian A-branes is generalized to other local toric Calabi-Yau geometries, which paves the road to study knots in other three-manifolds such as lens spaces.