The oral‐systemic personalized medicine model at Marshfield Clinic

Glurich, Ingrid; Acharya, Amit; Shukla, Sanjay Kumar; Nycz, Greg; Brilliant, Murray H.

doi:10.1111/j.1601-0825.2012.01921.x

Cited by 27 publications

(21 citation statements)

References 95 publications

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“…Close collaboration among each patient's health care professionals would be warranted, especially among medical and dental care providers (Glurich et al. ).…”

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confidence: 99%

Effect of periodontal disease on diabetes: systematic review of epidemiologic observational evidence

Borgnakke

Ylöstalo

Taylor

et al. 2013

J Clinic Periodontology

276

286

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RJ. Effect of periodontal disease on diabetes: systematic review of epidemiologic observational evidence. J Clin Periodontol 2013; 40 (Suppl. 14): S135-S152. doi: 10.1111/jcpe.12080. AbstractBackground: Periodontal disease and diabetes mellitus are common, chronic diseases worldwide. Epidemiologic and biologic evidence suggest periodontal disease may affect diabetes. Objective: To systematically review non-experimental, epidemiologic evidence for effects of periodontal disease on diabetes control, complications and incidence. Data sources: Electronic bibliographic databases, supplemented by hand searches of recent and future issues of relevant journals. Study eligibility criteria and participants: Longitudinal and cross-sectional epidemiologic, non-interventional studies that permit determination of directionality of observed effects were included. Study appraisal and synthesis methods: Four reviewers evaluated pair-wise each study. Review findings regarding study results and quality were summarized in tables by topic, using the PRISMA Statement for reporting and the NewcastleOttawa System for quality assessment, respectively. From 2246 citations identified and available abstracts screened, 114 full-text reports were assessed and 17 included in the review. Results: A small body of evidence supports significant, adverse effects of periodontal disease on glycaemic control, diabetes complications, and development of type 2 (and possibly gestational) diabetes. Limitations: There were only a limited number of eligible studies, several of which included small sample sizes. Exposure and outcome parameters varied, and the generalizability of their results was limited. Conclusions and implications of key findings: Current evidence suggests that periodontal disease adversely affects diabetes outcomes, and that further longitudinal studies are warranted.

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“…Close collaboration among each patient's health care professionals would be warranted, especially among medical and dental care providers (Glurich et al. ).…”

mentioning

confidence: 99%

Effect of periodontal disease on diabetes: systematic review of epidemiologic observational evidence

Borgnakke

Ylöstalo

Taylor

et al. 2013

J Clinic Periodontology

276

286

View full text Add to dashboard Cite

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“…Patient cohort data from these studies allow the inclusion of large numbers of patients with a wide coverage. It also enables researchers to have better understanding of the knowledge of the occurrence, prevention and effective treatment of the specific disease which ultimately improves personalised patient care (van't Riet et al , ; Glurich et al , ). Patient cohort data such as the General Practitioners Research Database (GPRD) from the United Kingdom (Mulnier et al , ; Azoulay et al , ), the Swedish National Diabetes Register (Eeg‐Olofsson et al , ), the China Kandoori Biobank (Chen et al , ) and the Diabetes Pearl Research Group (van't Riet et al , ) have played a major role in facilitating research concerning diabetes.…”

Section: Discussionmentioning

confidence: 99%

Establishing and managing a periodontal biobank for research: the sharing of experience

et al. 2014

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Periodontal bio-repositories, which allow banking of clinically validated human data and biological samples, provide an opportunity to derive biomarkers for periodontal diagnosis, prognosis and therapeutic activities which are expected to improve patient management. This article presents the establishing of the Malaysian Periodontal Database and Biobank System (MPDBS) which was initiated in 2011 with the aim to facilitate periodontal research. Partnerships were established with collaborating centres. Policies on specimen access, authorship and acknowledgement policies were agreed upon by all participating centres before the initiation of the periodontal biobank. Ethical approval for the collection of samples and data were obtained from institutional ethics review boards. A broad-based approach for informed consent was used, which covered areas related to quality of life impacts, genetics and molecular aspects of periodontal disease. Sample collection and processing was performed using a standardized protocol. Biobanking resources such as equipment and freezers were shared with the Malaysian Oral Cancer Database and Tissue Bank System (MOCDTBS). In the development of the MPDBS, challenges that were previously faced by the MOCDTBS were considered. Future challenges in terms of ethical and legal issues will be faced when international collaborations necessitate the transportation of specimens across borders.

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“…Bacterial infections were previously connected to malignancies because of their ability to promote chronic inflammation [76,77]. A recent study compared the microbial species from the tumor and non-tumor tissues of patients with OSCC using denaturing gradient gel electrophoresis (DGGE), cloning, and sequencing.…”

Section: Current State Of Ossc-specific Salivary Biomarkersmentioning

confidence: 99%

Salivary Biomarkers for Detection of Oral Squamous Cell Carcinoma: Current State and Recent Advances

Yakob

Fuentes

Wang

et al. 2014

Curr Oral Health Rep

118

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Oral squamous cell carcinoma (OSCC) is the most common malignant neoplasm of the oral cavity. Detection of OSCC is currently based on thorough clinical oral examination combined with biopsy for histological analysis. Most cases of OSCC are not detected until the cancer has developed into advanced stages; thus, a reliable early stage diagnostic marker is needed. This literature review presents an overview of the status of current advances in salivary diagnostics for OSCC. Though many protein and mRNA salivary biomarkers have been identified that can detect OSCC with high sensitivity and specificity, the most discernable findings occur with the use of multiple markers. Studies that incorporate proteomic, transcriptomic, and potentially additional “omics”, including methylomics, need to be initiated to bring technology to clinical applications and allow the best use of saliva in diagnosing OSCC.

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The oral‐systemic personalized medicine model at Marshfield Clinic

Cited by 27 publications

References 95 publications

Effect of periodontal disease on diabetes: systematic review of epidemiologic observational evidence

Effect of periodontal disease on diabetes: systematic review of epidemiologic observational evidence

Establishing and managing a periodontal biobank for research: the sharing of experience

Salivary Biomarkers for Detection of Oral Squamous Cell Carcinoma: Current State and Recent Advances

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