The Oral Side of Sjögren Syndrome. Diagnosis and Treatment. A Review

Soto-Rojas, Armando E.; Kraus, Arnoldo

doi:10.1016/s0188-4409(01)00371-x

Cited by 110 publications

(89 citation statements)

References 56 publications

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“…SS is classified as secondary (SS-2) when it is associated with other autoimmune diseases such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), and as primary (SS-1) when there is no other connective tissue disease (1,2). Several epidemiologic studies on SS have shown that the disease affects primarily females (nine fold higher than men) during the fourth and fifth decades of life (3).…”

Section: Introductionmentioning

confidence: 99%

Oral status and Candida colonization in patients with Sjogren s Syndrome

Ergün¹,

Çekici²,

Topçuoğlu³

et al. 2010

Med Oral

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Section: Introductionmentioning

confidence: 99%

Oral status and Candida colonization in patients with Sjogren s Syndrome

Ergün¹,

Çekici²,

Topçuoğlu³

et al. 2010

Med Oral

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“…In addition, salivary gland dysfunction is caused by Sjögren's syndrome, through multiple drug effects, and by senescence involving the replacement of the parenchyma with fat or connective tissue. Significant loss of function in the SMG leads to dry mouth, dental caries, a burning sensation in the mouth, difficulties in chewing and swallowing, and mucosal infection (Soto-Rojas and Kraus 2002). Therefore, the study of regeneration in the SMG is important to increase the quality of life.…”

Section: Introductionmentioning

confidence: 99%

Comparative analysis of ABCG2-expressing and label-retaining cells in mouse submandibular gland

et al. 2008

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The submandibular gland (SMG) is a tissue that can be regenerated in a tissue injury model and that has adult stem cells capable of self-renewal and differentiation into functional cells. We have analyzed the localization of label-retaining cells (LRCs), which are putative progenitor cells, by using the BrdU-labeling method. 5-Bromo-2'-deoxyuridine (BrdU) injection followed by a long chasing period permitted the identification of LRCs based on the slow-cycling characteristic. In order to confirm the accurate localization of LRCs, BrdU and SMG-specific markers, including aquaporin5, cytokeratin, and smooth muscle actin, were examined by double-immunofluorescence staining. We found that LRCs were distributed in the acinus, duct, myoepithelium, and connective tissue. Moreover, ABCG2 (a known stem cell marker) was used for the characterization of LRCs and the localization of cells as putative stem/progenitor cells. ABCG2-expressing cells were distributed in various regions of the SMG but did not co-localize with LRCs. We suggest that putative progenitor cells exist in various regions of the SMG and have diverse capacities to differentiate into specific cells.

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“…Regular use of fluoride dentifrices is mandatory, but products containing higher concentrations of fluoride are often recommended for patients with salivary gland hypofunction [6][7][8]. The preventive caries program consisting of meticulous oral hygiene and daily topical fluoride gel is confirmed and reliable method [9,10].…”

mentioning

confidence: 99%