The oral microbiome—the relevant reservoir for acute pediatric appendicitis?

Blod, Carlotta; Schlichting, Nadine; Schülin, Sara; Suttkus, Anne; Peukert, Nicole; Stîngu, Cătălina Suzana; Hirsch, Christian R; Elger, Wieland; Lacher, Martin; Bühligen, U.; Mayer, Steffi

doi:10.1007/s00384-017-2948-8

Cited by 30 publications

(33 citation statements)

References 48 publications

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“…Interaction of variable oral microorganisms helps human body against invasion of undesirable stimulation outside. However, imbalance of microbial flora contributes to oral diseases such as dental caries, periodontitis (Holt et al, 1988 ; Jorth et al, 2014 ; Liu et al, 2012 ; Philip et al, 2018 ; Wasfi et al, 2018 ; Costalonga and Herzberg, 2014 ), oral mucosal diseases (Saikaly, 2018 ) and systemic diseases, such as gastrointestinal and nervous systemic diseases (Jorth et al, 2014 ; Atarashi, 2017 ; Blod et al, 2017 ; Fardini et al, 2010 ; Kuczynski et al, 2012 ; Ling et al, 2015 ; Lirajunior and Boström, 2018 ; Peters et al, 2017 ; Plaza-Diaz et al, 2018 ; Reddy et al, 2018 ; Roszyk and Puszczewicz, 2017 ; Zarco et al, 2012 ). Oral microbiomes play an important role in the human microbial community and human health (Zarco et al, 2012 ).…”

Section: Introductionmentioning

confidence: 99%

Oral microbiomes: more and more importance in oral cavity and whole body

et al. 2018

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Microbes appear in every corner of human life, and microbes affect every aspect of human life. The human oral cavity contains a number of different habitats. Synergy and interaction of variable oral microorganisms help human body against invasion of undesirable stimulation outside. However, imbalance of microbial flora contributes to oral diseases and systemic diseases. Oral microbiomes play an important role in the human microbial community and human health. The use of recently developed molecular methods has greatly expanded our knowledge of the composition and function of the oral microbiome in health and disease. Studies in oral microbiomes and their interactions with microbiomes in variable body sites and variable health condition are critical in our cognition of our body and how to make effect on human health improvement.

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Section: Introductionmentioning

confidence: 99%

Oral microbiomes: more and more importance in oral cavity and whole body

et al. 2018

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“…Oral microbes contributed strongly to shape human health, its dysbiosis in early life related to many oral diseases, including dental caries, periodontitis, and oral mucosal diseases (13,14). Moreover, dynamic changes were observed in oral bacterial composition during pregnancy and childhood development (15).…”

Section: Introductionmentioning

confidence: 99%

The Initial Oral Microbiota of Neonates Among Subjects With Gestational Diabetes Mellitus

Xiao

et al. 2019

Front. Pediatr.

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The objective was to investigate the potential effect of gestational diabetes mellitus on the initial neonatal oral microbiome community structure. Methods: Oral samples were collected from 20 full-term, vaginally delivered newborns with sterile swabs. Nine of them had mothers diagnosed with gestational diabetes mellitus (GDM group), while 11 had non-diabetic mothers (NDM group). The oral microbiota was analyzed using multi-barcode 16S rRNA sequencing on Illumina MiSeq system. Results: The results showed that the birth weight, gestational age and gestational weight gain were significantly higher in NDM group. There was a significant correlation between gestational age and birth weight. Neonatal oral microbiome was composed of five dominant phyla from Actinobacteria, Bacteroidetes, Firmicutes, Proteobacteria, and Tenericutes. Compared to NDM group, a higher alpha diversity and reduction of phylum Firmicutes were observed in GDM group. Genus Lactobacillus dominated in NDM group, while Alistipes, Streptococcus, and Faecalibacterium were overabundant in GDM group. Additionally, carbohydrate metabolism increased in NDM group, whereas amino acid metabolism, vitamin metabolism and lipopolysaccharide biosynthesis were more abundant in GDM group. Conclusions: This study showed a distinct oral microbiota profile in neonates born to mothers with GDM, which indicated that maternal diabetes status played an important role in neonatal initial oral microbiota.

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“…The complex and variable interaction of oral microbes helps the body to fight against the external undesirable stimuli. However, the imbalances of microbial community in oral cavity can lead to the oral diseases, such as the dental caries, periodontitis, oral mucosal diseases and systemic diseases such as gastrointestinal and neurological diseases [2,[4][5][6][7][8][9][10][11][12][13]. Therefore, the oral microbiome plays an important role in maintaining the balance between human microbial communities and human health [14,15].…”

Section: Introductionmentioning

confidence: 99%

Human oral microbiome characterization and its association with environmental microbiome revealed by the Earth Microbiome Project

Wang

et al. 2019

Preprint

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The oral cavity is an important window for the microbial communication between environment and the human body. The oral microbiome plays an important role in human health. Here, we analyzed 447 datasets from human oral samples published by the Earth Microbiome Project (EMP). The microbes in these human oral samples were taxonomically assigned to at least 266 genera of 18 bacterial and archaeal phyla. Among them, 11 genera with the relative abundance more than 1% were identified as 5 different bacterial phyla. Compared with 815 samples from human gut, nose/pharynx and skin, the oral microbiome showed significantly lower diversity and possessed fewer unknown species than those of other body parts, and had distinct differences in species composition from other body parts. In addition, the oral microbiome showed significant differences in the populations of different countries, which may be determined by the living environment and lifestyle/dietary habits. Finally, the correlation analysis showed highly similarity between the oral microbiome and the microbiomes of Aerosol (non-saline) and Surface (non-saline), two types of environmental microbial habitats related closely to human. Together, these findings expand our understanding to the human oral microbiome.

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The oral microbiome—the relevant reservoir for acute pediatric appendicitis?

Cited by 30 publications

References 48 publications

Oral microbiomes: more and more importance in oral cavity and whole body

Oral microbiomes: more and more importance in oral cavity and whole body

The Initial Oral Microbiota of Neonates Among Subjects With Gestational Diabetes Mellitus

Human oral microbiome characterization and its association with environmental microbiome revealed by the Earth Microbiome Project

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