The oral microbiome of patients undergoing treatment for severe aplastic anemia: a pilot study

Ames, Nancy J.; Barb, Jennifer; Ranucci, Alexandra; Kim, H; Mudra, Sarah; Cashion, Ann K.; Townsley, Danielle M.; Childs, Richard W.; Paster, Bruce J.; Faller, Lina L.; Wallen, Gwenyth R.

doi:10.1007/s00277-019-03599-w

Cited by 23 publications

(20 citation statements)

References 51 publications

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“…The most common oral organisms, e.g., Streptococcus, Gemella, and Veillonella, remained relatively stable after transplant 34 . However, another study showed a reduction in alpha diversity after allo-HSCT when compared with the pretransplant OM 35 , and this reduction was more pronounced in patients who developed oral mucositis 48 . Besides, we did not nd any direct correlation between the use of antibiotics after conditioning and transplant outcomes, as other studies have shown for IM diversity 23,24 .…”

Section: Discussionmentioning

confidence: 95%

“…OM disruption has been observed in several diseases, including diabetes, autoimmune diseases, endocarditis, gastrointestinal cancer, head and neck cancer [30][31][32] , and acute lymphoblastic leukemia 33 . Changes in the OM in patients undergoing allo-HSCT are known to be associated with respiratory signs and symptoms 34 and oral mucositis 35 ; however, no correlation between OM and allo-HSCT outcomes have been reported to date. Accordingly, in this study, we evaluated whether the OM disruption is related to outcomes in patients who underwent allo-HSCT.…”

Section: Introductionmentioning

confidence: 99%

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Disruption of the Oral Microbiota Is Associated With a Higher Risk of Relapse After Allogeneic Hematopoietic Stem Cell Transplantation

Molla

Heidrich

Bruno

et al. 2021

Preprint

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Background: Intestinal microbiota (IM) diversity and composition regulates host immunity and affects outcomes after allogeneic stem cell transplantation (allo-HSCT). Methods: We evaluated how the oral mucosa microbiota (OM) impacts the outcomes in patients who underwent allo-HSCT. Samples from the oral mucosa of 30 patients were collected at three time points: before the conditioning, at aplasia, and at engraftment. We analyzed the associations of OM diversity and composition with allo-HSCT outcomes. Results: Higher OM diversity at preconditioning was associated with a lower risk of relapse in 3 years (33% versus 68%, respectively; P = 0.04). Dominance (relative abundance ≥30%) by a single genus at preconditioning was associated with a higher risk of relapse (63% versus 36%, respectively; P = 0.04), worse progression-free survival (PFS; 19% versus 55%, respectively; P = 0.01), and poorer overall survival (OS) at 3 years (38% versus 81%, respectively; P= 0.02). Conclusion: The presence of Solobacterium at preconditioning was associated with a lower risk of relapse (9% versus 56%, respectively; P = 0.04). This is the first study to address the relationship between OM and clinical outcomes after allo-HSCT.

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Section: Discussionmentioning

confidence: 95%

Section: Introductionmentioning

confidence: 99%

Disruption of the Oral Microbiota Is Associated With a Higher Risk of Relapse After Allogeneic Hematopoietic Stem Cell Transplantation

Molla

Heidrich

Bruno

et al. 2021

Preprint

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“…The copyright holder for this preprint this version posted February 8, 2021. ; https://doi.org/10.1101/2021.02.04.21251019 doi: medRxiv preprint context, studies are still limited and have focused mainly on the saliva and the tongue microbiota [38][39][40][41] .…”

Section: (Which Was Not Certified By Peer Review)mentioning

confidence: 99%

Dental biofilm microbiota dysbiosis is associated with the risk of acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation

Heidrich

Bruno

et al. 2021

Preprint

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Acute graft-versus-host disease (aGVHD) is one of the major causes of death after allogeneic hematopoietic stem-cell transplantation (allo-HSCT). Recently, aGVHD onset was linked to intestinal microbiota (IM). However, other bacterial-rich gastrointestinal sites, such as the mouth, which hosts several distinctive microbiotas, may also impact the risk of GVHD. The dental biofilm microbiota (DBM) is highly diverse and, like the IM, interacts with host cells and modulates immune homeostasis. We characterized changes in the DBM of patients during allo-HSCT and evaluated whether the DBM could be associated with the risk of aGVHD. DBM dysbiosis during allo-HSCT was marked by a gradual loss of bacterial diversity. We observed significant changes in DBM genera composition, with a decrease in the abundance of commensal genera, and overgrowths of potentially pathogenic bacteria. High Streptococcus and high Corynebacterium relative abundance at preconditioning were associated with higher risk of aGVHD (67% vs. 33%; HR = 2.89, P = 0.04 and 73% vs. 37%; HR = 2.74, P = 0.04, respectively), while high Veillonella relative abundance was associated with a lower risk of aGVHD (27% vs. 73%; HR = 0.24, P < 0.01). Enterococcus faecalis bloom was observed in 20% of allo-HSCT recipients' DBM and was significantly associated with a higher risk of aGVHD (100% vs. 40%; HR = 4.07, P < 0.001) and severe aGVHD (60% vs. 12%; HR = 6.82, P = 0.01). To the best of our knowledge, this is the first study demonstrating that DBM dysbiosis is associated with the aGVHD risk after allo-HSCT.

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“…Nurse scientists have a long history in examining the oral environment as a way to improve care (Ames et al, 2011; Feider et al, 2010; Munro & Baker, 2018; Prendergast et al, 2009). Focusing on the study of the oral microbiome is the next step in this science as oral cavity health status is linked to systemic outcomes (Acharya et al, 2017; Ames et al, 2019; Chapple et al, 2017; Farquhar et al, 2017; Lockhart et al, 2012). Nevertheless, the majority of studies exploring the human microbiome have collected fecal samples aimed at analyzing the gut microbiome as a sole measure.…”

mentioning

confidence: 99%

The Oral and Gut Bacterial Microbiomes: Similarities, Differences, and Connections

Maki

Kazmi

Barb

et al. 2020

Biological Research For Nursing

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Background: The oral cavity is associated with local and systemic diseases, although oral samples are not as commonly studied as fecal samples in microbiome research. There is a gap in understanding between the similarities and differences in oral and gut microbiomes and how they may influence each other. Methods: A scoping literature review was conducted comparing oral and gut microbiome communities in healthy humans. Results: Ten manuscripts met inclusion criteria and were examined. The oral microbiome sites demonstrated great variance in differential bacterial abundance and the oral microbiome had higher alpha diversity as compared to the gut microbiome. Studies using 16S rRNA sequencing analysis resulted in overall community differences between the oral and gut microbiomes when beta diversity was analyzed. Shotgun metagenomics sequencing increased taxonomic resolution to strain level (intraspecies) and demonstrated a greater percentage of shared taxonomy and oral bacterial translocation to the gut microbiome community. Discussion: The oral and gut microbiome bacterial communities may be more similar than earlier research has suggested, when species strain is analyzed through shotgun metagenomics sequencing. The association between oral health and systemic diseases has been widely reported but many mechanisms underlying this relationship are unknown. Although future research is needed, the oral microbiome may be a novel interventional target through its downstream effects on the gut microbiome. As nurse scientists are experts in symptom characterization and phenotyping of patients, they are also well posed to lead research on the connection of the oral microbiome to the gut microbiome in health and disease.

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The oral microbiome of patients undergoing treatment for severe aplastic anemia: a pilot study

Cited by 23 publications

References 51 publications

Disruption of the Oral Microbiota Is Associated With a Higher Risk of Relapse After Allogeneic Hematopoietic Stem Cell Transplantation

Disruption of the Oral Microbiota Is Associated With a Higher Risk of Relapse After Allogeneic Hematopoietic Stem Cell Transplantation

Dental biofilm microbiota dysbiosis is associated with the risk of acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation

The Oral and Gut Bacterial Microbiomes: Similarities, Differences, and Connections

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