2023
DOI: 10.2147/idr.s411615
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The Oral Lesion in the COVID-19 Patient: Is It True Oral Manifestation or Not?

Abstract: Objective Many previously reported publications mentioned that oral lesion in COVID-19 patients was varied. The term oral manifestations refer to pathognomonic features that are found consistently with a specific cause and effect. In this context, the oral manifestation of COVID-19 was inconclusive. This systematic review aimed to analyse previously reported publications related to oral lesions in COVID-19 patients to define as oral manifestations or not. The PRISMA guidelines were implemented in … Show more

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Cited by 4 publications
(4 citation statements)
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References 139 publications
(756 reference statements)
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“…ACE-2 is suspected to serve as the initial receptor for developing oral lesions in SARS-CoV-2-infected patients. With ACE2 expression, oral tissues could facilitate direct SARS-CoV-2 invasion, contributing to its pathogenesis and potentially enhancing human-to-human transmission rates [6,16]. Limongelli et al [18].…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…ACE-2 is suspected to serve as the initial receptor for developing oral lesions in SARS-CoV-2-infected patients. With ACE2 expression, oral tissues could facilitate direct SARS-CoV-2 invasion, contributing to its pathogenesis and potentially enhancing human-to-human transmission rates [6,16]. Limongelli et al [18].…”
Section: Discussionmentioning
confidence: 99%
“…The term “oral manifestations” has not yet been conclusively associated with pathognomonic features of COVID-19. Sarasati et al [ 16 ]. found inconsistencies and the absence of pathognomonic features in previous studies on oral lesions in COVID-19 patients.…”
Section: Discussionmentioning
confidence: 99%
“…Estimates of the prevalence of COVID-19 associated oral lesions vary widely due to differences in study methodologies and patient populations. However, studies suggest that oral lesions may affect a significant proportion of COVID-19 patients, with some reports indicating a prevalence of up to 30% [ 24 , 28 ].…”
Section: Discussionmentioning
confidence: 99%
“…A wide range of clinical oral lesions was attributed to SARS-CoV-2 infection and it has been covered in a vast body of literature, which is beyond the aim of the present study [37,38]. However, when data was compilated, selected and systematically analyzed it became obvious that lesions lacked pathognomonic features and were inconsistent so that the current published literature does not allow establishment of a direct link between the oral lesions and causation by SARS-CoV-2 infection, but seems that these were rather related to oral manifestations secondary to existing comorbidities, secondary infections, or the treatment given to combat COVID-19 disease [39][40][41][42][43][44]. Furthermore, the interesting finding of ACE2 isoforms that do not bind SARS-CoV-2 [45][46][47][48], means that identification of ACE2 in host cells does not automatically mean universal viral attachment and infection potential, and should be further analyzed on a personalized level for individual susceptibility for infection.…”
Section: Plos Onementioning
confidence: 90%