The oral cavity as a port of entry for early infections in patients treated with bone marrow transplantation

Heimdahl, Anders; Mattsson, Torsten; Dahllöf, Göran; Lönnquist, Berk; Ringdén, Olle

doi:10.1016/0030-4220(89)90160-6

Cited by 118 publications

(65 citation statements)

References 8 publications

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“…Numerous studies have investigated the immediate effects of chemotherapy and/or radiation on the oral mucosa and other perioral soft tissues, [1][2][3][4][5][6][7][8][9][10][11][12] but few have addressed late dental sequelae of cancer treatment received at an early age. Nasam, 13 Kaste et al [14][15][16] observed hypodontia, microdontia, enamel hypoplasia, root stunting, taurodontia, over-retention of primary teeth, and an increased caries index in survivors of childhood cancer.…”

Section: Discussionmentioning

confidence: 99%

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Dental abnormalities in children preparing for pediatric bone marrow transplantation

Vaughan

Rowland

Tong

et al. 2005

Bone Marrow Transplant

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Summary:The purpose of our study was to describe the types and frequencies of altered dental development in pediatric patients preparing for bone marrow transplantation (BMT). Retrospective review of the medical records and panoramic radiographs of all patients who underwent BMT at St Jude Children's Research Hospital between 1990 and 2000 for whom pre-BMT dental examination and panoramic radiography records were available. All patients were treated on institutional protocols. We recorded patient demographics and radiographic evidence of microdontia, hypodontia, taurodontia, root stunting, caries, enamel pearls, and pulpal calcifications. The 259 patients identified (150 male and 109 female) had a median age of 12.82 years (range, 3.18-25.93 years) at the time of BMT. In total, 203 were Caucasian, 38 were African-American, and 18 were of other races. In all, 150 (57.9%) had abnormal dentition. The most common dental abnormalities were caries (n ¼ 84), pulpal calcifications (n ¼ 34), and dental extractions (n ¼ 33). Developmental abnormalities occurred less frequently: taurodontia (n ¼ 8), hypodontia (n ¼ 10), microdontia (n ¼ 11), and root stunting (n ¼ 11). Dental abnormalities are prevalent in children undergoing BMT. Pre-transplant oral hygiene and dental examination should be standard care in order to minimize potential sites of infection.

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Section: Discussionmentioning

confidence: 99%

“…6,8,9 Their increased frequency is likely multifactorial and resulting from poor oral hygiene, altered salivary pH and diet. Radiation of 1000 cGy or more may result in reduced salivary flow and a resultant altered pH balance in the oral cavity, causing a shift in oral flora and an increase in caries.…”

Section: Discussionmentioning

confidence: 99%

Dental abnormalities in children preparing for pediatric bone marrow transplantation

Vaughan

Rowland

Tong

et al. 2005

Bone Marrow Transplant

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“…8 Therefore, to prevent significant morbidity, all sources of potential infection should be identified upon pre-transplant dental screening and treated appropriately. 2,9,10 Not all previous studies have supported a need for pre-HSCT dental treatment. Melkos et al 11 reported that there was no significant difference in the occurrence of infection originating from oral disease during and after HSCT therapy between patients, with and without pre-HSCT dental treatments, but they did not describe in detail the severity of the dental diseases of the patients in their study.…”

Section: Introductionmentioning

confidence: 99%

A prospective study to evaluate a new dental management protocol before hematopoietic stem cell transplantation

Yamagata

Onizawa

Yanagawa

et al. 2006

Bone Marrow Transplant

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“…Numerous studies have investigated the immediate effects of chemotherapy and/or radiation on the oral mucosa and other perioral soft tissues, [1][2][3][4][5][6][7][8][9] but few have addressed the late dental sequelae of cancer treatment received at an early age. Hypodontia, microdontia, enamel hypoplasia, root stunting, taurodontia, over-retention of primary teeth, and an increased caries index have been reported in survivors of childhood cancer.…”

mentioning

confidence: 99%

Dental abnormalities after pediatric bone marrow transplantation

Vaughan

Rowland

Tong

et al. 2005

Bone Marrow Transplant

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Summary:Our purpose was to describe the types and frequencies of altered dental development in pediatric patients following bone marrow transplantation (BMT). A retrospective review of the medical records and panoramic radiographs of all patients who underwent BMT at St Jude Children's Research Hospital between 1990 and 2000, for whom pre-BMT and post-BMT dental examination and panoramic radiography records were available, is presented. All patients were treated on institutional protocols. We recorded patient demographics and radiographic evidence of microdontia, hypodontia, taurodontia, root stunting, caries, enamel pearls, dental restorations/extractions and pulpal calcification. The 99 patients identified (52 males, 47 females) had a median age of 13.5 years (range, 3.4-25.9 years) at the time of BMT. In all, 73 were Caucasian, 15 were African-American, and 11 were of other races. The frequency of radiographically evident root stunting in permanent teeth was significantly increased after BMT (Po0.001), but there was no significant change in the frequency of other dental abnormalities after BMT. Dental abnormalities are prevalent in survivors of childhood BMT, but only root stunting appeared to progress with BMT. Bone Marrow Transplantation (2005) 36, 725-729.

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The oral cavity as a port of entry for early infections in patients treated with bone marrow transplantation

Cited by 118 publications

References 8 publications

Dental abnormalities in children preparing for pediatric bone marrow transplantation

Dental abnormalities in children preparing for pediatric bone marrow transplantation

A prospective study to evaluate a new dental management protocol before hematopoietic stem cell transplantation

Dental abnormalities after pediatric bone marrow transplantation

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