The Oral Carriage of Candida in Oral Cancer Patients of Indian Origin Undergoing Radiotherapy and/or Chemotherapy

Jain, Manish; Shah, Raksha; Chandolia, Betina; Mathur, Ayush; Chauhan, Yashwant; Chawda, Jyoti; Mosby, Siddarth; Bhagalia, Sanjay

doi:10.7860/jcdr/2016/15702.7180

Cited by 35 publications

(42 citation statements)

References 18 publications

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“…In our study population of postradiotherapy head and neck cancer patients with xerostomia, we found that 87.5% were Candida carriers. The result is consistent with previous studies which reported 55%–100% Candida colonization in postradiotherapy cancer patients (de Freitas et al, ; Jain et al, ; Karbach et al, ; Thaweboon et al, ). The prevalence was considerably higher than previously reported 25.7%–55% Candida colonization in healthy population (Ergun et al, ; Lam‐Ubol et al, ; Meurman et al, ; Sun et al, ; Thanyasrisung et al, ).…”

Section: Discussionsupporting

confidence: 93%

“…Thus, the information regarding risk factors associated with oral colonization of Candida species is important for identifying ways to reduce risk for this critical opportunistic infection in these patients.In our study population of postradiotherapy head and neck cancer patients with xerostomia, we found that 87.5% were Candida carriers. The result is consistent with previous studies which reported 55%-100% Candida colonization in postradiotherapy cancer patients(de Freitas et al, 2013;Jain et al, 2016;Karbach et al, 2012;Thaweboon et al, 2008). The prevalence was considerably higher than previously reported 25.7%-55% Candida colonization in healthy population(Ergun et al, 2010;Lam-Ubol et al, 2019;Meurman et al, 2007;Sun et al, 2016;Thanyasrisung et al, 2014).…”

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confidence: 93%

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Oral Candida colonization in xerostomic postradiotherapy head and neck cancer patients

et al. 2019

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Objectives To evaluate (a) oral colonization of Candida species, especially for non‐albicans Candida species (NACS), in xerostomic postradiotherapy head and neck cancer patients and (b) risk factors affecting their colonization. Materials and methods Subjective and objective dry mouth scores, stimulated salivary flow rates, pH and buffering capacity were measured in 72 xerostomic postradiotherapy head and neck cancer patients. Candida counts and species identification were performed using oral rinse samples cultured in Candida Chromagar, followed by polymerase chain reaction and API 20C AUX system. Results Candida colonization was observed in 87.5% of subjects, with 80.6% and 48.6% of study population colonized by C. albicans and NACS, respectively. NACS was associated with high objective dry mouth scores, denture use, and females (p = .006, .009, and .036, respectively). In addition, Candida glabrata was detected more in females (p = .018) and denture wearers (p = .026), while Candida tropicalis was associated with high objective dry mouth scores (p = .022) and females (p = .027). Quantity of Candida colonization correlated positively with objective dry mouth scores (r = 0.599, p < .001) and negatively with salivary flow rates (r = −0.258, p = .041) and pH (r = −0.290, p = .022). Conclusion NACS colonization was common in xerostomic head and neck cancer patients. Increased signs of dry mouth, female and dental prostheses may promote NACS colonization.

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Section: Discussionsupporting

confidence: 93%

supporting

confidence: 93%

Oral Candida colonization in xerostomic postradiotherapy head and neck cancer patients

et al. 2019

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“…Referente a la infección por el virus herpes simple, ocurre en el 21 al 90% de los pacientes seropositivos que reciben altas dosis de quimioterapia, especialmente en pacientes receptores de trasplantes. Esta infección se asocia a grados graves de mucositis [15][16][17] . De acuerdo con nuestras observaciones, la implementación de una buena higiene oral y el uso de un protocolo de cuidado oral normalizado para todos los niños susceptibles de MO es tan importante como utilizar láser terapéutico, ya que la asociación no significativa entre utilizar o no TLBP no disminuye el riesgo de padecer MO.…”

Section: Discussionunclassified

Impacto de un protocolo de prevención y atención de mucositis oral en pacientes con diagnóstico oncológico pediátrico

Ávila-Sánchez

Purizaca-Bazán

Félix-Bermúdez

et al. 2022

GAMO

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Resumen Introducción: La mucositis oral (MO) es una complicación frecuente asociada al tratamiento oncológico, y puede ir desde un grado leve a uno grave. Hasta el 80% de los niños sometidos a quimioterapia experimentarán algún grado de MO, que puede llegar a incrementar la mortalidad hasta en un 40% en los casos graves. Aunque la incidencia de MO difiere de acuerdo con el tipo de cáncer y el régimen de tratamiento, los niños con neoplasias hematológicas experimentan una incidencia y una prevalencia mayores que aquellos niños con diagnóstico de tumores sólidos. De acuerdo con lo anterior, la MO llega a representar una causa importante en la reducción de dosis común protocolizada y por lo tanto un retraso en el tratamiento, por lo que este trabajo analiza el impacto que se ha tenido en la prevención y el tratamiento oportuno de la MO, además de contribuir a estadísticas nacionales que aún no se encuentran reportadas. Material y métodos: Estudio retrospectivo y descriptivo de 157 pacientes con diagnóstico oncológico pediátrico atendidos durante el periodo de septiembre de 2014 a junio de 2016 con riesgo de presentar un evento de MO durante su etapa de tratamiento. Resultados: La presentación de MO fue del 21.6% y la prevalencia anual fue del 2.6%, del total de 1731 valoraciones. Conclusiones: Nuestros resultados son prometedores y se propone ampliar el tamaño de la muestra, así como la perspectiva de colaboración con otras instituciones, para promover un protocolo estandarizado del cuidado bucal en niños con diagnóstico oncológico. (creativecommons.org/licenses/by-nc-nd/4.0/). ARTÍCULO ORIGINALImpacto de un protocolo de prevención y atención de mucositis oral en pacientes con diagnóstico oncológico pediátrico

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“…With regard to HSV infection, it occurs in 21% to 90% of seropositive patients who receive high-dose chemotherapy, especially in transplanted patients. This infection is associated with severe grades of mucositis [15][16][17] . According to our observations, implementation of good oral hygiene and the use of a standardized oral care protocol for all OM-susceptible children is as important as the use of therapeutic laser, since the non-significant association between using or not low-level laser does not decrease the risk to suffer OM.…”

Section: Description Of Therapeutic Protocols Used By the Department mentioning

confidence: 99%

Impact of a protocol for the prevention and care of oral mucositis in pediatric patients diagnosed with cancer

Ávila-Sánchez¹,

Purizaca-Bazán²,

Félix-Bermúdez³

et al. 2022

GAMO

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Introduction: Oral mucositis (OM) is a common complication associated with cancer treatment, and it can range from mild to severe degree. Up to 80% of children undergoing chemotherapy will experience some degree of OM, which can get to increase mortality by up to 40% in severe cases. Although OM incidence differs according to cancer type and treatment regimen, children with hematological malignancies experience higher incidence and prevalence than children diagnosed with solid tumors. According to the above, OM is likely to represent a major cause for common protocol-indicated dose reduction and, hence, for treatment delay. Therefore, this work analyzes approaches that been used to impact on OM prevention and opportune treatment, in addition to contributing to yet-unpublished national statistics. Material and Methods: This was a retrospective, descriptive study of 157 cancer-diagnosed pediatric patients attended to during the period from September 2014 to June 2016 and who were at risk for experiencing an OM event during their treatment stage. Results: OM occurrence was 21.6% and annual prevalence was 2.6% out of a total of 1731 assessments. Conclusions: Our results are promising, and expanding the sample size, as well the perspective of collaboration with other institutions is suggested in order to promote a standardized oral care protocol for children diagnosed with cancer. (creativecommons.org/licenses/by-nc-nd/4.0/). KEYWORDSOral mucositis; Pediatric cancer; Oral care protocol Protocol for the prevention and care of oral mucositis in pediatric patients diagnosed with cancer 97

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The Oral Carriage of Candida in Oral Cancer Patients of Indian Origin Undergoing Radiotherapy and/or Chemotherapy

Cited by 35 publications

References 18 publications

Oral Candida colonization in xerostomic postradiotherapy head and neck cancer patients

Oral Candida colonization in xerostomic postradiotherapy head and neck cancer patients

Impacto de un protocolo de prevención y atención de mucositis oral en pacientes con diagnóstico oncológico pediátrico

Impact of a protocol for the prevention and care of oral mucositis in pediatric patients diagnosed with cancer

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