The optimum number of oocytes in IVF treatment: an analysis of 2455 cycles in China

Ji, Jingjuan; Liu, Yusheng; Tong, Xian Hong; Luo, Lan; Ma, Jinlong; Chen, Zi‐Jiang

doi:10.1093/humrep/det303

Cited by 164 publications

(105 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The iET can also avoid unnecessarily submitting suboptimal responders to this strategy, which would lead to an unnecessary increase in treatment costs and delays in the embryo transfer. Previous studies have evaluated live birth rates in a fresh cycle, as well as cumulative live birth rates, correlating these outcomes to ovarian response [30,40]. The authors of these studies observed that when stratifying patients by the number of retrieved oocytes, the live birth rate following a fresh embryo transfer fails to increase when over 10-11 oocytes are retrieved.…”

Section: Discussionmentioning

confidence: 99%

Freeze-all cycle for all normal responders?

Roque

Valle

Guimarães

et al. 2016

J Assist Reprod Genet

View full text Add to dashboard Cite

Purpose The purpose of this study is to evaluate the freeze-all strategy in subgroups of normal responders, to assess whether this strategy is beneficial regardless of ovarian response, and to evaluate the possibility of implementing an individualized embryo transfer (iET) based on ovarian response. Methods This was an observational, cohort study performed in a private IVF center. A total of 938 IVF cycles were included in this study. The patients were submitted to controlled ovarian stimulation (COS) with a gonadotropin-releasing hormone (GnRH) antagonist protocol and a cleavage-stage day 3 embryo transfer. We performed a comparison of outcomes between the fresh embryo transfer (n = 523) and the freezeall cycles (n = 415). The analysis was performed in two subgroups of patients based on the number of retrieved oocytes: Group 1 (4-9 oocytes) and Group 2 (10-15 oocytes). Result(s) In Group 1 (4-9 retrieved oocytes), the implantation rates (IR) were 17.9 and 20.5% (P = 0.259) in the fresh and freeze-all group, respectively; the ongoing pregnancy rates (OPR) were 31 and 33% (P = 0.577) in the fresh and freezeall group, respectively. In Group 2 (10-15 oocytes), the IR were 22.1 and 30.1% (P = 0.028) and the OPR were 34 and 47% (P = 0.021) in the fresh and freeze-all groups, respectively. Conclusion(s) Although the freeze-all policy may be related to better in vitro fertilization (IVF) outcomes in normal responders, these potential advantages decrease with worsening ovarian response. Patients with poorer ovarian response do not benefit from the freeze-all strategy.

show abstract

Section: Discussionmentioning

confidence: 99%

Freeze-all cycle for all normal responders?

Roque

Valle

Guimarães

et al. 2016

J Assist Reprod Genet

View full text Add to dashboard Cite

show abstract

“…However, according to the literature [8,24], both groups of patients have been found to exhibit good prognoses considering the number of retrieved oocytes. When between 6 and 15 oocytes are retrieved, the pregnancy rates for one fresh ET are similar, and when oocyte numbers are either below or above that range, outcomes are compromised [25]. We observed statistically significant differences between the groups with P/F AFC antral follicle count, P progesterone, E 2 estradiol, MII mature eggs * The results are expressed as the mean±SD ratios that were under or over the established cut-off, suggesting that these ratios had different consequences on endometrial receptivity according to both ovarian response and P level.…”

Section: Discussionmentioning

confidence: 99%

Ratio of progesterone-to-number of follicles as a prognostic tool for in vitro fertilization cycles

Roque

Valle

Sampaio

et al. 2015

J Assist Reprod Genet

View full text Add to dashboard Cite

Purpose To establish a ratio of the P level to the number of follicles (P/F ratio) on the day of human chorionic gonadotropin (hCG) administration and to evaluate whether this ratio is associated with in vitro fertilization (IVF) outcome. Methods This study was conducted between January 2012 and June 2013. A total of 337 patients with cleavage-stage day-3 fresh embryo transfer with P levels ≤1.5 ng/mL on the day of hCG administration were included in the study. The main outcome was ongoing pregnancy rate. Result(s) The P/F ratio was calculated according to the equation (P[ng/mL]/number of follicles) on the day of final oocyte maturation. Using ROC, we established a cut-off level of 0.075 for the P/F ratio. The area under the curve (AUC) (0.756; 95 % confidence interval [CI]: 0.704-0.807) indicated that it was a good prognostic test. In group 1 (patients under 36 years old), the ongoing pregnancy rates were 57 and 30 % for patients with P/F ratios≤.075 and>.075, respectively, (p= 0.003). In group 2 (patients between 36 and 39 years old), the ongoing pregnancy rates were 58 % and 17 % (p=0.001) for patients with P/F ratios ≤.075 and>.075, respectively. In group 3 (patients≥40 years old), the ongoing pregnancy rates were 41.7 and 10.9 % (p=0.001) for patients with P/F ratios≤.075 and>.075, respectively. Conclusions The P/F ratio is a good prognostic test for predicting IVF outcome that can correlate the P level with ovarian response.

show abstract

“…We would expect that a higher number of oocytes would result in a higher pregnancy rate. Indeed, the studies of Van der Gaast et al, 30 Sunkara et al, 31 Mc Avey et al 32 and Ji et al 33 showed a positive correlation between number of oocytes and pregnancy rates (up to 15 oocytes). However, the association between AMH levels and IVF success has been controversial.…”

Section: Discussionmentioning

confidence: 96%

Correlation of serum anti-Müllerian hormone levels with positive in vitro fertilization outcome using a short agonist protocol

Mantzavinos

Vlahos

Rizos

et al. 2017

View full text Add to dashboard Cite

OBJECTIVE: We examined the predictive ability of anti-Müllerian hormone (AMH) for clinical pregnancy in women who underwent in vitro fertilization (IVF) cycles in a short agonist protocol. DESIGN: This is a retrospective cohort study of 222 women undergoing their first IVF attempt between June 2010 and March 2016. Multivariate logistic regression analysis was performed to evaluate the independent associations between clinical pregnancy and its possible predictors. RESULTS: 14.9% of cycles were cancelled, >3 oocytes were retrieved in 55.4% of cycles and embryo transfer was performed in 70.7% of cases. Live birth was the final outcome in 19.8% of subjects, miscarriage occurred in 4.1%, whereas no pregnancy occurred in the remaining 76.1% of the study sample. The number of oocytes, number of embryos, embryo transfer rate and pregnancy rates were positively associated with serum AMH concentrations (p <0.001, for each association). When analyzed by age quartiles, the overall association between AMH and clinical pregnancy rates was evident across all age strata. CONCLUSIONS: Serum AMH levels are a strong predictive marker of clinical pregnancy in women undergoing a short agonist IVF protocol. There is also a strong association with cancellation rate, number of oocytes retrieved, poor response (≤3 oocytes), number of embryos, embryo transfer rate and live birth rates.

show abstract

The optimum number of oocytes in IVF treatment: an analysis of 2455 cycles in China

Abstract: This study was supported by the Medical Scientific Research Plan Project of Anhui Provincial Department of Health (13ZC014) and the Natural Science Foundation of Anhui Higher Education Institutions (KJ2013Z132).

Cited by 164 publications

References 44 publications

Freeze-all cycle for all normal responders?

Freeze-all cycle for all normal responders?

Ratio of progesterone-to-number of follicles as a prognostic tool for in vitro fertilization cycles

Correlation of serum anti-Müllerian hormone levels with positive in vitro fertilization outcome using a short agonist protocol

Contact Info

Product

Resources

About