Prediction and parameter optimization are effective methods for mine personnel to control blast-induced ground vibration. However, the challenge of effective prediction and optimization lies in the multi-factor and multi-effect nature of open-pit blasting. This study proposes a hybrid intelligent model to predict ground vibrations using a least-squares support vector machine (LSSVM) optimized by a particle swarm algorithm (PSO). Meanwhile, multi-objective particle swarm optimization (MOPSO) was used to optimize the blast design parameters by considering the vibration of particular areas and the bulk rate of blast fragmentation. To compare the prediction performance of PSO-LSSVM, a genetic-algorithm-optimized BP neural network (GA-BP), unoptimized LSSVM, and BP were used, by applying the same database. In addition, the root-mean-squared error (RMSE), the mean absolute error (MAE), and the correlation coefficient (r) were regarded as the evaluation indicators. Furthermore, the optimization results of the blasting parameters were obtained by quoting the established vibration prediction model and bulk rate proxy model in MOPSO and verified by field tests. The results indicated that the PSO-LSSVM model provided the highest efficiency in predicting vibrations with an RMSE of 1.954, MAE of 1.717, and r of 0.965. Furthermore, the blasting vibration can be controlled by using the two-objective optimization model to obtain the best blasting parameters. Consequently, this study can provide more specific recommendations for vibration hazard control.