The optimal use of granulocyte macrophage colony stimulating factor in radiation induced mucositis in head and neck squamous cell carcinoma.

Patni, Nidhi; Patni, Sanjeev; Bapna, Ajay

doi:10.4103/0973-1482.19589

Cited by 14 publications

(8 citation statements)

References 25 publications

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“…Use of granulocyte/macrophage-colony stimulating factor (GM-CSF) has been used to ameliorate mucositis in cancer patients treated with radiotherapy,63 and to treat chemotherapy-induced neutropenia in many patients treated with chemotherapy 64. Although it is critical for these patients to receive G-CSF/GM-CSF to avoid treatment delays, recent research indicates a potential danger involving the stimulation of tumor angiogenesis by myeloid cells.…”

Section: Clinical Importance and Implicationsmentioning

confidence: 99%

Influence of bone marrow-derived hematopoietic cells on the tumor response to radiotherapy: Experimental models and clinical perspectives

Ahn¹,

Brown²

2009

Cell Cycle

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In this review, we highlight some of recent studies underscoring the importance of the tumor microenvironment, especially the role of bone marrow-derived myeloid cells, in restoring tumor growth after irradiation. Myeloid cells are hematopoietic cells that give rise to monocytes and macrophages in the peripheral blood and tissues. These cells have been shown to be proangiogenic in tumors promoting tumor growth. We also discuss our previously unpublished results on the effect of irradiation on the tumor vasculature including pericyte and basement membrane coverage to the endothelium of tumor blood vessels. We summarize the clinical significance of these studies including the use of MMP-9 inhibitors, administering white blood cell boosters, or planning safety margin of tumor volumes, in order to improve overall clinical benefits in cancer patients treated with radiotherapy.

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Section: Clinical Importance and Implicationsmentioning

confidence: 99%

Influence of bone marrow-derived hematopoietic cells on the tumor response to radiotherapy: Experimental models and clinical perspectives

Ahn¹,

Brown²

2009

Cell Cycle

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“…However, this study was not randomized and there was no placebo or treatment control group. Several other studies have since supported this finding and some even suggested that GM-CSF is more useful in patients receiving hyperfraction RT [1,67,68]. A more recent study using a higher subcutaneous dose of 4 μg/kg/day suggested that GM-CSF is more effective than conventional treatment in severe mucositis [69].…”

Section: G-csf/cm-csfmentioning

confidence: 76%

“…Radiation therapy (RT) is an important and indispensable mode of treatment for head and neck cancers, with up to 75% of all head and neck cancer patients receiving it [1]. As it is currently not possible to prevent radiation therapyinduced mucositis (RM) from happening, most healthcare workers aim to at least provide symptomatic relief to alleviate patients' suffering.…”

Section: Introductionmentioning

confidence: 99%

Management of radiation therapy-induced mucositis in head and neck cancer patients. Part II: supportive treatments

2008

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Oropharyngeal mucositis is the acute inflammatory and ulcerative reaction of the oral mucosa following radiation therapy to the head and neck region. It is such a common problem that nearly all head and neck cancer patients develop some degree of mucositis. This complication is usually transient in nature but it also represents an important clinical problem as it is a painful, debilitating, dose-dependent side effect for which there is no widely acceptable prophylaxis or effective treatment. As several authoritative groups have recently either undertaken systematic reviews or issued guidelines on the management of mucositis, it is the aim of this review instead, to provide an overview of all the remedies and pharmaceutical agents available, as well as highlighting to researchers the gaps that need to be filled.

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“…No intraoral tumor ablative procedures that altered the mucosal surfaces were carried out. 11 All the procedures were performed in accordance with the hospital's ethical guidelines.…”

Section: Patient Selection and Characteristicsmentioning

confidence: 99%

The effects of recombinant human granulocyte colony-stimulating factor mouthwash on radiotherapy-induced oral mucositis in locally advanced nasopharyngeal carcinoma patients

Liang¹,

Du²,

Ke³

et al. 2017

Adv Clin Exp Med

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The optimal use of granulocyte macrophage colony stimulating factor in radiation induced mucositis in head and neck squamous cell carcinoma.

Cited by 14 publications

References 25 publications

Influence of bone marrow-derived hematopoietic cells on the tumor response to radiotherapy: Experimental models and clinical perspectives

Influence of bone marrow-derived hematopoietic cells on the tumor response to radiotherapy: Experimental models and clinical perspectives

Management of radiation therapy-induced mucositis in head and neck cancer patients. Part II: supportive treatments

The effects of recombinant human granulocyte colony-stimulating factor mouthwash on radiotherapy-induced oral mucositis in locally advanced nasopharyngeal carcinoma patients

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