The optimal therapeutic timing and mechanism of puerarin treatment of spinal cord ischemia–reperfusion injury in rats

Tian, Feng; Xu, Lihui; Zhao, Wei; Tian, Lijie; Ji, Xianglu

doi:10.1016/j.jep.2011.01.055

Cited by 34 publications

(27 citation statements)

References 30 publications

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“…The SCII model proposed by Zivin et al has been developed into a mature and reliable model. Although initially developed in rabbits, many following studies have proved its effectiveness in rats (Usul et al, 2004;Wang and Jiang, 2009;Tian et al, 2011). All animals were prohibited from drinking during the morning of the surgery.…”

Section: Rat Model Of Acute Sciimentioning

confidence: 99%

Panax notoginsenoside produces neuroprotective effects in rat model of acute spinal cord ischemia–reperfusion injury

Ning

Dang

Bai

et al. 2012

Journal of Ethnopharmacology

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Section: Rat Model Of Acute Sciimentioning

confidence: 99%

Panax notoginsenoside produces neuroprotective effects in rat model of acute spinal cord ischemia–reperfusion injury

Ning

Dang

Bai

et al. 2012

Journal of Ethnopharmacology

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“…Previous studies revealed that puerarin might possess many physiological and pharmacological activities and has long been used for cardiovascular diseases, such as coronary artery disease, myocardial damage, and heart failure [18–20]. Puerarin also shows antioxidative [21] and antiallergic activities [22].…”

Section: Introductionmentioning

confidence: 99%

Puerarin Attenuates Ovalbumin‐Induced Lung Inflammation and Hemostatic Unbalance in Rat Asthma Model

Dong

Wang

Duan

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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Aim. We aimed to investigate and evaluate the preventive activity of puerarin on the ovalbumin-induced asthma rat model. Materials and Methods. Male Wistar rats were sensitized intraperitoneally on days 0, 7, and 14 and challenged to ovalbumin intratracheally on day 21. Groups of sensitized rats were treated randomly either with placebo, puerarin, dexamethasone, or puerarin combined with dexamethasone, from days 15 to 20. Inflammatory markers, including cell counts in bronchoalveolar lavage fluid (BALF), inflammatory cytokines, histopathology, and coagulation parameters, such as coagulation tests and the activity of coagulation factors, were analyzed. Results. Puerarin significantly inhibited the recruitment of inflammatory cells in BALF and lung tissue. At the same time, the release of IL-4, IL-10, and IFN-γ in serum and the expression of mRNAs in lung tissue homogenate were changed by puerarin. Administration of puerarin also effectively rectified the coagulation disorder in asthmatic rats, such as prothrombin time (PT) (P < 0.01), thrombin time (TT) (P < 0.05), fibrinogen (FIB) (P < 0.01),the activity of factor II (FII) (P < 0.01), the activity of factor V (FV) (P < 0.05), the activity of factor VII (FVII) (P < 0.05), the activity of factor X (FX) (P < 0.05), the activity of factor VIII (FVIII) (P < 0.01), the activity of factor IX (FIX) (P < 0.05), and the activity of factor XII (FXII) (P < 0.05). Conclusions. Our results provide a clue that puerarin was useful for the preventive of allergic airway disease in rodents.

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“…It has been widely used in treatment of various diseases such as cardiovascular disorder, neurodegenerative disease, cancer, diabetes and ischemic stroke [16]. Importantly, studies have demonstrated that puerarin had neuroprotective effect on spinal cord ischemia-reperfusion injury in rats [17,18]. In addition, Heng LS et al reported that puerarin could attenuate secondary injury in early SCI [19].…”

Section: Introductionmentioning

confidence: 99%

The Neuroprotective Effect of Puerarin in Acute Spinal Cord Injury Rats

Zhang

Hou

et al. 2016

Cell Physiol Biochem

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Background: Acute spinal cord injury (SCI) leads to permanent disabilities. This study evaluated the neuroprotective effect of puerarin, a natural extract, in a rat model of SCI. Methods: Acute SCI models were established in rats using a modified Allen's method. Locomotor function was evaluated using the BBB test. The histological changes in the spinal cord were observed by H&E staining. Neuron survival and glial cells activation were evaluated by immunostaining. ELISA and realtime PCR were used to measure secretion and gene expression of cytokines. TUNEL staining was used to examine cell apoptosis and western blot analysis was used to detect protein expression. Results: Puerarin significantly increased BBB score in SCI rats, attenuated histological injury of spinal cord, decreased neuron loss, inhibited glial cells activation, alleviated inflammation, and inhibited cell apoptosis in the injured spinal cords. In addition, the downregulated PI3K and phospho-Akt protein expression were restored by puerarin. Conclusion: Puerarin accelerated locomotor function recovery and tissue repair of SCI rats, which is associated with its neuroprotection, glial cell activation suppression, anti-inflammatory and anti-apoptosis effects. These effects may be associated with the activation of PI3K/Akt signaling pathway.

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The optimal therapeutic timing and mechanism of puerarin treatment of spinal cord ischemia–reperfusion injury in rats

Cited by 34 publications

References 30 publications

Panax notoginsenoside produces neuroprotective effects in rat model of acute spinal cord ischemia–reperfusion injury

Panax notoginsenoside produces neuroprotective effects in rat model of acute spinal cord ischemia–reperfusion injury

Puerarin Attenuates Ovalbumin‐Induced Lung Inflammation and Hemostatic Unbalance in Rat Asthma Model

The Neuroprotective Effect of Puerarin in Acute Spinal Cord Injury Rats

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