The optimal bowel preparation intervals before colonoscopy: A randomized study comparing polyethylene glycol and low-volume solutions

Kojecký, Vladimír; Matouš, Jan; Keil, Radan; Dastych, Milan; Zádorová, Zdena; Varga, Michal; Kroupa, Radek; Dolina, Jiří; Mišurec, Miroslav; Hep, Aleš; Gřiva, Martin

doi:10.1016/j.dld.2017.10.010

Cited by 10 publications

(22 citation statements)

References 16 publications

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“…Some authors have reported better results of inpatient colonoscopy preparation with split-dose administration of 4 L polyethylene glycol (PEG) [15], based on the outpatient data that shows that splitdose PEG solution is superior to single-dosing [8,16,17]. In the outpatient setting, it is known that timing between completion of purgative intake and the colonoscopy is an important factor for bowel-preparation quality, regardless if the procedure is performed in the morning or afternoon [9][10][11]. In our study, we used split dosing of bowel preparation in all subjects, giving half of the solution starting the evening prior to day of procedure and the remaining half in the morning of the planned procedure.…”

Section: Discussionmentioning

confidence: 99%

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Effect of bowel preparation volume in inpatient colonoscopy. Results of a prospective, randomized, comparative pilot study

et al. 2020

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Background: Inpatient status has been shown to be a predictor of poor bowel preparation for colonoscopy; however, the optimal bowel preparation regimen for hospitalized patients is unknown. Our aim was to compare the efficacy of bowel preparation volume size in hospitalized patients undergoing inpatient colonoscopy. Methods: This prospective, single blinded (endoscopist), randomized controlled trial was conducted as a pilot study at a tertiary referral medical center. Hospitalized patients undergoing inpatient colonoscopy were assigned randomly to receive a high, medium, or low-volume preparation. Data collection included colon preparation quality, based on the Boston Bowel Preparation Scale, and a questionnaire given to all subjects evaluating the ability to completely finish bowel preparation and adverse effects (unpleasant taste, nausea, and vomiting). Results: Twenty-five colonoscopies were performed in 25 subjects. Patients who received low-volume preparation averaged a higher mean total BBPS (7.4, SD 1.62), in comparison to patients who received high-volume (7.0, SD 1.41) and medium-volume prep (6.9, SD 1.55), P = 0.77. When evaluating taste a higher score meant worse taste. The low-volume group scored unpleasant taste as 0.6 (0.74), while the high-volume group gave unpleasant taste a score of 2.2 (0.97) and the medium-volume group gave a score of 2.1 (1.36), P < 0.01. Conclusion: In this pilot study we found that low-volume colon preparation may be preferred in the inpatient setting due its better rate of tolerability and comparable bowel cleanliness when compared to larger volume preparation, although we cannot overreach any definitive conclusion. Further more robust studies are required to confirm these findings. Trial registration: The Affect of Low-Volume Bowel Preparation for Hospitalized Patients Colonoscopies. Trial registration: NCT01978509 (terminated). Retrospectively registered on November 07, 2013.

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Section: Discussionmentioning

confidence: 99%

“…Studies in outpatient populations have demonstrated that timing and choice of cathartic medication affects the cleanliness of the bowel preparations [9][10][11]. However, no standardized (or optimized) bowel preparation regimen exists for inpatient populations undergoing colonoscopy.…”

Section: Introductionmentioning

confidence: 99%

Effect of bowel preparation volume in inpatient colonoscopy. Results of a prospective, randomized, comparative pilot study

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Some authors have reported better results of inpatient colonoscopy preparation with split-dose administration of 4-liter polyethylene glycol (PEG) [15], based on the outpatient data that shows that split-dose PEG solution is superior to single-dosing [8,16,17]. In the outpatient setting, it is known that timing between completion of purgative intake and the colonoscopy is an important factor for bowel-preparation quality, regardless if the procedure is performed in the morning or afternoon [9][10][11]. In our study, we used split dosing of bowel preparation in all subjects received colon cleansing preparations giving half of the solution starting the evening prior to day of procedure and the remaining half in the morning of the planned procedure.…”

Section: Discussionmentioning

confidence: 99%

Effect of Bowel Preparation Volume in Inpatient Colonoscopy. Results of a Prospective, Randomized, Comparative Pilot Study

Hernandez

Horsley‐Silva

Snyder

et al. 2020

Preprint

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Background: Inpatient status has been shown to be a predictor of poor bowel preparation for colonoscopy; however, the optimal bowel preparation regimen for hospitalized patients is unknown. Our aim was to compare the efficacy of bowel preparation volume size in hospitalized patients undergoing inpatient colonoscopy. Methods: This prospective, single blinded (endoscopist), randomized controlled trial was conducted as a pilot study at a tertiary referral medical center. Hospitalized patients undergoing inpatient colonoscopy were assigned randomly to receive a high, medium, or low-volume preparation. Data collection included colon preparation quality, based on the Boston Bowel Preparation Scale, and a questionnaire given to all subjects evaluating the ability to completely finish bowel preparation and adverse effects (unpleasant taste, nausea, and vomiting). Results: Twenty-five colonoscopies were performed in 25 subjects. Patients who received low-volume preparation averaged a higher mean total BBPS (7.4, SD 1.62), in comparison to patients who received high-volume (7.0, SD 1.41) and medium-volume prep (6.9, SD 1.55), P = 0.77. When evaluating taste a higher score meant worse taste. The low-volume group scored unpleasant taste as 0.6 (0.74), while the high-volume group gave unpleasant taste a score of 2.2 (0.97) and the medium-volume group gave a score of 2.1 (1.36), P < 0.01. Conclusion: In this pilot study, the low-volume colon preparation Prepopik® may be preferred in the inpatient setting due its better rate of tolerability and comparable bowel cleanliness when compared to larger volume preparation, although we cannot overreach any definitive conclusion. Further more robust studies are required to confirm these findings.

show abstract

“…Some authors have reported better results of inpatient colonoscopy preparation with split-dose administration of 4-liter polyethylene glycol (PEG) [15], based on the outpatient data that shows that splitdose PEG solution is superior to single-dosing [8,16,17]. In the outpatient setting, it is known that timing between completion of purgative intake and the colonoscopy is an important factor for bowel-preparation quality, regardless if the procedure is performed in the morning or afternoon [9][10][11]. In our study, we used split dosing of bowel preparation in all subjects, giving half of the solution starting the evening prior to day of procedure and the remaining half in the morning of the planned procedure.…”

Section: Discussionmentioning

confidence: 99%

Effect of Bowel Preparation Volume in Inpatient Colonoscopy. Results of a Prospective, Randomized, Comparative Pilot Study

Hernandez

Horsley‐Silva

Snyder

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Inpatient status has been shown to be a predictor of poor bowel preparation for colonoscopy; however, the optimal bowel preparation regimen for hospitalized patients is unknown. Our aim was to compare the efficacy of bowel preparation volume size in hospitalized patients undergoing inpatient colonoscopy.Methods: This prospective, single blinded (endoscopist), randomized controlled trial was conducted as a pilot study at a tertiary referral medical center. Hospitalized patients undergoing inpatient colonoscopy were assigned randomly to receive a high, medium, or low-volume preparation. Data collection included colon preparation quality, based on the Boston Bowel Preparation Scale, and a questionnaire given to all subjects evaluating the ability to completely finish bowel preparation and adverse effects (unpleasant taste, nausea, and vomiting). Results: Twenty-five colonoscopies were performed in 25 subjects. Patients who received low-volume preparation averaged a higher mean total BBPS (7.4, SD 1.62), in comparison to patients who received high-volume (7.0, SD 1.41) and medium-volume prep (6.9, SD 1.55), P = 0.77. When evaluating taste a higher score meant worse taste. The low-volume group scored unpleasant taste as 0.6 (0.74), while the high-volume group gave unpleasant taste a score of 2.2 (0.97) and the medium-volume group gave a score of 2.1 (1.36), P < 0.01.Conclusion: In this pilot study we found that low-volume colon preparation may be preferred in the inpatient setting due its better rate of tolerability and comparable bowel cleanliness when compared to larger volume preparation, although we cannot overreach any definitive conclusion. Further more robust studies are required to confirm these findings.Trial registration: clinicaltrials.gov NCT01978509

show abstract

The optimal bowel preparation intervals before colonoscopy: A randomized study comparing polyethylene glycol and low-volume solutions

Cited by 10 publications

References 16 publications

Effect of bowel preparation volume in inpatient colonoscopy. Results of a prospective, randomized, comparative pilot study

Effect of bowel preparation volume in inpatient colonoscopy. Results of a prospective, randomized, comparative pilot study

Effect of Bowel Preparation Volume in Inpatient Colonoscopy. Results of a Prospective, Randomized, Comparative Pilot Study

Effect of Bowel Preparation Volume in Inpatient Colonoscopy. Results of a Prospective, Randomized, Comparative Pilot Study

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