The OPRM1 A118G polymorphism modulates the descending pain modulatory system for individual pain experience in young women with primary dysmenorrhea

Wei, Shyh Yuh; Chen, Lifen; Lin, Ming‐Wei; Li, Wei‐Chi; Low, Intan; Yang, Ching-Ju; Chao, Hsiang‐Tai; Hsieh, Jen Chuen

doi:10.1038/srep39906

Cited by 30 publications

(27 citation statements)

References 57 publications

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“… 38 Similarly, one recent study found lower heat pain thresholds in women with PD compared to women without PD when tested on the abdomen, although these differences did not reach statistical significance. 39 …”

Section: Resultsmentioning

confidence: 99%

“… 41 Women with and without PD have also shown similar heat and cold pain thresholds when tested on the abdomen during the periovulatory period. 38 , 39 …”

Section: Resultsmentioning

confidence: 99%

“…Variations in type and intensity of stimuli used may account for some of these seemingly contradictory findings. For example, Lee et al 38 and Wei et al 39 restricted the temperature range on the heat thermode from 0°C to 50°C, which may have unintentionally created a ceiling effect due to a low maximum temperature. However, generally, results suggest that women with PD do experience hypersensitivity to areas of referred pain.…”

Section: Resultsmentioning

confidence: 99%

“… 44 Women with PD have also reported higher peak pain during the menstrual phase than women without PD following a saline injection into the forearm, 37 and in a subsequent study testing muscle ischemia, the authors found that women with PD reported higher pain ratings compared to controls during menstruation. 47 Women with PD have higher heat pain thresholds when tested on the forearm during menstruation, 39 and report more pain from a bladder distension during menstruation, 48 when compared to women without PD.…”

Section: Resultsmentioning

confidence: 99%

“… 48 Heat pain thresholds on the forearm are also higher in women with PD compared to women without PD in the periovulatory period. 39 …”

Section: Resultsmentioning

confidence: 99%

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Experimental and procedural pain responses in primary dysmenorrhea: a systematic review

Payne¹,

Rapkin²,

Seidman³

et al. 2017

JPR

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Primary dysmenorrhea (PD) has been the focus of a number of experimental pain studies. Although a number of reviews exist, few have critically evaluated the existing body of research on PD and experimental and procedural pain. Data from 19 published research articles that include women with PD and responses to an experimental or procedural pain stimulus (or stimuli) suggest that women with PD may have elevated pain reactivity, as compared to women without PD. This pattern appears to be true across different phases of the menstrual cycle. However, there is an abundance of conflicting findings, which may be due to significant methodological issues such as inconsistent definitions of PD, wide variation in experimental pain methodologies, and inaccurate assessment of the menstrual cycle. Future research should focus on identifying specific symptoms (i.e., pain threshold ratings) to more clearly define what constitutes PD, establish reliable and valid laboratory testing protocols, and assess the menstrual cycle with greater precision.

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Section: Resultsmentioning

confidence: 99%

“… 41 Women with and without PD have also shown similar heat and cold pain thresholds when tested on the abdomen during the periovulatory period. 38 , 39 …”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“… 48 Heat pain thresholds on the forearm are also higher in women with PD compared to women without PD in the periovulatory period. 39 …”

Section: Resultsmentioning

confidence: 99%

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Experimental and procedural pain responses in primary dysmenorrhea: a systematic review

Payne¹,

Rapkin²,

Seidman³

et al. 2017

JPR

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Polymorphisms of the μ‐opioid receptor gene influence cerebral pain processing in fibromyalgia

Ellerbrock

Sandström

Tour

et al. 2020

European Journal of Pain

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Background: Dysregulation of the μ-opioid receptor has been reported in fibromyalgia (FM) and was linked to pain severity. Here, we investigated the effect of the functional genetic polymorphism of the μ-opioid receptor gene (OPRM1) (rs1799971) on symptom severity, pain sensitivity and cerebral pain processing in FM subjects and healthy controls (HC). Methods: Symptom severity and pressure pain sensitivity was assessed in FM subjects (n = 70) and HC (n = 35). Cerebral pain-related activation was assessed by functional magnetic resonance imaging during individually calibrated painful pressure stimuli. Results: Fibromyalgia subjects were more pain sensitive but no significant differences in pain sensitivity or pain ratings were observed between OPRM1 genotypes. A significant difference was found in cerebral pain processing, with carriers of at least one G-allele showing increased activation in posterior cingulate cortex (PCC) extending to precentral gyrus, compared to AA homozygotes. This effect was significant in FM subjects but not in healthy participants, however, between-group comparisons did not yield significant results. Seed-based functional connectivity analysis was performed with the seed based on differences in PCC/precentral gyrus activation between OPRM1 genotypes during evoked pain across groups. G-allele carriers displayed decreased functional connectivity between PCC/precentral gyrus and prefrontal cortex. Conclusions: G-allele carriers showed increased activation in PCC/precentral gyrus but decreased functional connectivity with the frontal control network during pressure stimulation, suggesting different pain modulatory processes between OPRM1 genotypes involving altered fronto-parietal network involvement. Furthermore, our results suggest that the overall effects of the OPRM1 G-allele may be driven by FM subjects. Significance: We show that the functional polymorphism of the μ-opioid receptor gene OPRM1 was associated with alterations in the fronto-parietal network as well as with increased activation of posterior cingulum during evoked pain in FM. Thus, the OPRM1 polymorphism affects cerebral processing in brain regions implicated This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Placebo Hypoalgesic Effects and Genomics

Colloca

Raghuraman

2020

Genomics of Pain and Co-Morbid Symptoms

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The OPRM1 A118G polymorphism modulates the descending pain modulatory system for individual pain experience in young women with primary dysmenorrhea

Cited by 30 publications

References 57 publications

Experimental and procedural pain responses in primary dysmenorrhea: a systematic review

Experimental and procedural pain responses in primary dysmenorrhea: a systematic review

Polymorphisms of the μ‐opioid receptor gene influence cerebral pain processing in fibromyalgia

Placebo Hypoalgesic Effects and Genomics

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