The opposite effect of a 5-HT1B receptor agonist on 5-HT synthesis, as well as its resistant counterpart, in an animal model of depression

Skelin, Ivan; Kovačević, Tomislav; Sato, Hiroki; Dikšić, Mirko

doi:10.1016/j.brainresbull.2012.04.009

Cited by 4 publications

(4 citation statements)

References 57 publications

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“…The results of the present study including the fact that the pharmacological validity of the FST and TST was reproduced by the U-field test ( Fig. 3 ) support the envision that the TST and FST measure psychomotor retardation, which were previously proposed [ 21 , 22 , 23 ] and is a core symptom of depression suggested by the Diagnostic and Statistical Manual of Mental Disorders (DSM-V).…”

Section: Discussionsupporting

confidence: 88%

Implementation of a Two-dimensional Behavior Matrix to Distinguish Individuals with Differential Depression States in a Rodent Model of Depression

et al. 2014

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Animal models of depression are used to study pathophysiology of depression and to advance therapeutic strategies. Stress-induced depression models in rodents are widely used. However, amenable behavioral criteria and experimental procedures that are suitable for animal models have not been established. Given that depression is clinically diagnosed by multiple symptomatic criteria and stress effects are imposed to the brain non-specifically in stress-induced depression models, analyses of depression states in rodents using multiple symptomatic criteria may provide more power than any methods relying on a single symptomatic criterion. To address this, C57BL/6 inbred mice were restrained for 2 h daily for 14 d, and depression states of individual mice were assessed using the U-field test, behavioral assessment developed to measure animal's sociability, and the tail suspension test and/or forced swim test, which are the typical methods that measure psychomotor withdrawal states. Although the majority of these mice showed severe depressive behaviors in both tests, a significant proportion of them, which were all inbred mice and received the same amount of restraints, expressed differential depression states in the sociability test and psychomotor withdrawal tests. To easily read-out differential depression states of individuals in two different tests, a standard method and basic parameters required to construct two-way behavior matrix were introduced. The utility and features of this two-way behavior analysis method for studies of different depressive states of individuals were discussed.

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Section: Discussionsupporting

confidence: 88%

Implementation of a Two-dimensional Behavior Matrix to Distinguish Individuals with Differential Depression States in a Rodent Model of Depression

et al. 2014

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“… 89 , 90 It has been shown that the 5-HT 1B receptor agonist CP-94253 can modulate 5-HT synthesis in the Flinders Sensitive Line rat, an animal model of depression. 91 In intracerebral microdialysis studies, stimulation of 5-HT 1B receptors by RU 24969 potentiated the antidepressant-like effects of SSRIs and imipramine. 92 Additionally, 5-HT 1B receptor stimulation with the selective agonist CP-94253 in mice displayed an antidepressant-like profile in the forced swim test.…”

Section: Modulation Of Glutamate Transmission By 5-ht Receptorsmentioning

confidence: 99%

“…The 5-HT 1B receptor has been implicated in the pathophysiology and treatment of depression 89 90 It has been shown that the 5-HT 1B receptor agonist CP-94253 can modulate 5-HT synthesis in the Flinders Sensitive Line rat, an animal model of depression 91 . In intracerebral microdialysis studies, stimulation of 5-HT 1B receptors by RU 24969 potentiated the antidepressant-like effects of SSRIs and imipramine 92 .…”

Section: Modulation Of Glutamate Transmission By 5-ht Receptorsmentioning

confidence: 99%

Serotonergic modulation of glutamate neurotransmission as a strategy for treating depression and cognitive dysfunction

2013

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Monoamine-based treatments for depression have evolved greatly over the past several years, but shortcomings such as suboptimal efficacy, treatment lag, and residual cognitive dysfunction are still significant. Preclinical and clinical studies using compounds directly targeting glutamatergic neurotransmission present new opportunities for antidepressant treatment, with ketamine having a surprisingly rapid and sustained antidepressant effect that is presumably mediated through glutamate-dependent mechanisms. While direct modulation of glutamate transmission for antidepressant and cognition-enhancing actions may be hampered by nonspecific effects, indirect modulation through the serotonin (5-HT) system may be a viable alternative approach. Based on localization and function, 5-HT can modulate glutamate neurotransmission at least through the 5-HT1A, 5-HT1B, 5-HT3, and 5-HT7 receptors, which presents a rational pharmacological opportunity for modulating glutamatergic transmission without the direct use of glutamatergic compounds. Combining one or more of these glutamate-modulating 5-HT targets with 5-HT transporter inhibition may offer new therapeutic opportunities. The multimodal compounds vortioxetine and vilazodone are examples of this approach with diverse mechanisms, and their different clinical effects will provide valuable insights into serotonergic modulation of glutamate transmission for the potential treatment of depression and associated cognitive dysfunction.

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“…Such data would depend on the duration of 5-HT1B modulations and presence of antidepressant-like effect [159].…”

Section: -Ht1b and Depressionmentioning

confidence: 99%

Association of Platelet Serotonin Levels in Alzheimer’s Disease with Clinical and Cerebrospinal Fluid Markers

Tajeddinn

Fereshtehnejad

Ahmed

et al. 2016

JAD

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The opposite effect of a 5-HT1B receptor agonist on 5-HT synthesis, as well as its resistant counterpart, in an animal model of depression

Cited by 4 publications

References 57 publications

Implementation of a Two-dimensional Behavior Matrix to Distinguish Individuals with Differential Depression States in a Rodent Model of Depression

Implementation of a Two-dimensional Behavior Matrix to Distinguish Individuals with Differential Depression States in a Rodent Model of Depression

Serotonergic modulation of glutamate neurotransmission as a strategy for treating depression and cognitive dysfunction

Association of Platelet Serotonin Levels in Alzheimer’s Disease with Clinical and Cerebrospinal Fluid Markers

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