The opioid crisis and … reconsidering the use of drugs that affect body temperature

Patwardhan, Amol; Porreca, Frank; Schmidt, William K.; Romanovsky, Andrej A.

doi:10.1080/23328940.2018.1437312

Cited by 3 publications

(5 citation statements)

References 5 publications

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“…In warm environments, the hypothalamus is activated, stimulating the release of mediators that promote vasodilation [40]. This can result in an increase in the heart rate, favouring a greater surface permeability, allowing the blood to carry out the heat exchange with the periphery of the body, mainly through the dissipation of heat by convection and radiation [25,26]. If these mechanisms are not sufficient to cool the body, the sweat process is triggered, which facilitates thermal exchange by evaporating sweat [3,4].…”

Section: Physiological Effects Of Thermoregulation and Hypothermiamentioning

confidence: 99%

“…Anesthesia-induced hypothermia is associated with a number of significant health-related problems, including increased infection at the surgical site [6], increased bleeding [15], increased stay in the post-anesthetic recovery unit which takes longer hospitalizations and increased pain [17,26]. With this in mind, the aim of this review was to provide comprehensive information on the effects of perioperative hypothermia and its risks and consequences in patients undergoing the anesthetic act inside and outside the surgical block, from the study of the current available literature.…”

Section: Introductionmentioning

confidence: 99%

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Hypothermia Effects Observed Under Anesthesia: An Integrative Literature Review

Salgado,

Barros,

Auzier

et al. 2023

JAMMR

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Of the regular temperature of approximately 37°C, about 0.8°C are dedicated to the internal maintenance of the brain, heart and organs located in the abdomen, being said of the central temperature, with the aim of avoiding large variations in temperature, in order to favour the functions of the vital systems. When the central temperature drops to less than 36°C, then hypothermia occurs.The studies suggest the control and monitoring of the patient's temperature during surgery, and point out strategies for the maintenance of the temperature and loss of heat in the patient, from preheating with varying duration thermal blanket and heating of intravenous fluids.Thinking about this, the objective of this review was to provide comprehensive information about the effects of perioperative hypothermia and its risks and consequences in patients undergoing the anesthetic act within and outside the surgical block, from the study of the current available literature.The research led to ten publications, mostly listed with level I evidence (5); in other level II articles (2); only one level III article and fourth level articles. All the papers explored the control, monitoring, consequences and risks of perioperative hypothermia. Concluding that continuing education, training, building skills to implement the current hypothermia management guidelines and institutional support are fundamental aspects inining episodes of perioperative hypothermie.

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Section: Physiological Effects Of Thermoregulation and Hypothermiamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hypothermia Effects Observed Under Anesthesia: An Integrative Literature Review

Salgado,

Barros,

Auzier

et al. 2023

JAMMR

View full text Add to dashboard Cite

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“…The Centers for Disease Control and Prevention (CDC) reports that in 2012 there were 259 million prescriptions for opioid substances in the United States of America (USA), and that in 2013 there were 16,235 overdoses deaths [8]. Surprisingly, in 2017, 70,237 people died in this country from abusive use of opioids, which corresponds to an increase of 9.6% compared to 2016 [6,8].…”

Section: Why Alternatives To Opioids Are Neededmentioning

confidence: 99%

“…Although opioid analgesics remain the most effective pharmacological class in the control of moderate to severe pain, it brings with it great additive potential for physical-chemical dependence, in addition to adverse effects such as nausea, constipation, euphoria, respiratory depression, drowsiness, urinary retention, hyperalgesia and tolerance, which are often not taken into account [6][7][8][9][10][11][12][13].…”

Section: Acute Postoperative Painmentioning

confidence: 99%

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Viminol hydroxybenzoate as a non-narcotic analgesic pharmacological choic

Hummig¹,

Kubiak²,

Cardoso³

et al. 2022

GSC Adv. Res. Rev.

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Acute postoperative pain is a constant challenge for medical professionals, who seek to choose drugs capable of generating a high degree of analgesia, without, however, inducing adverse effects, such as: intense sedation, gastrointestinal effects, addiction and breathing depression, inherent to opioids. It is already well known that narcotic analgesics constitute the pharmacological group most used in the immediate postoperative period. Here we present Viminol Hydroxybenzoate which has peculiar analgesic characteristics, being considered a potent non-narcotic analgesic of central action and equipotent to codeine. The aim of this study was to highlight the prescriptive importance of Viminol Hydroxybenzoate in the context of acute postoperative pain, explore its pharmacological aspects and warn about the prescriptive risk of opioids. Thus, we suggest the use of Viminol Hydroxybenzoate as an interesting therapeutic alternative to replace opioids, especially in conditions of mild to moderate acute postoperative pain, capable of providing a reduction in pain and, consequently, a better quality of life for patients, without the deleterious effects of opioids.

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