“…Being cognizant of such a broad range of options, our examination considers categories of data which may fit into a functional definition of DSI, namely: DNA, RNA, protein, genetic markers (with or without sequences), non-coding features and other data categories (Houssen et al, 2020;Brink et al, 2021) and specifically suggests ways to link these data to other ontologized knowledge to accommodate expansive views of DSI. As best practice, existing ontology may be used where each concept bears a unique and resolvable identifier, called a Uniform Resource Identifier, for which the definition, context of use and semantic relationships are validated by a large community (Arnaud et al, 2020). For example, the Sequence Ontology, the Protein Ontology, and the Gene Ontology, which include concepts and definitions of Genomic Objects along with other relevant ontologies, such as the NCBI taxonomy for species, and metadata standards, such as the Biosample record, may provide a useful point of departure.…”