The ontogeny and developmental physiology of gastric acid secretion

Marciano, Tuvia; Wershil, Barry K.

doi:10.1007/s11894-007-0063-7

Cited by 12 publications

(4 citation statements)

References 20 publications

(16 reference statements)

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“…It is known that stomach full development during the fetal period is up to the 14 th or 15 th gestational week and that 27-week-old preterm infants are capable of gastric pH <4.0 on the first day of life. However, in the first 48 hours after birth, the literature indicates that the pH may be higher due to low gastric acid secretion, lack of food or the presence of amniotic fluid in the stomach ( 15 - 17 ) .…”

Section: Introductionmentioning

confidence: 99%

Use of pH reagent strips to verify gastric tube placement in newborns

Dias¹,

Almeida

Álvares

et al. 2019

Rev. Latino-Am. Enfermagem

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Objective:to confirm the accuracy of the pH test in identifying the placement of the gastric tube in newborns.Method:double-blind, diagnostic test study conducted with 162 newborns admitted to a neonatal intensive care unit and an intermediate care unit. The subjects were submitted to enteral intubation, followed by pH test with reagent strip, which was analyzed by a nurse, and radiological examination, analyzed by radiologist. Blinding was kept among professionals regarding test results. Diagnostic accuracy analysis of the pH test in relation to the radiological exam was performed.Results:the sample consisted of 56.17% boys, with average birth weight of 1,886.79g (SD 743,41), 32.92 (SD 2.99) weeks of gestational age and the mean pH was 3.36 (SD 1.27). Considering the cutoff point of pH≤5.5, the sensitivity was 96.25%, specificity 50%, positive predictive value 99.35% and negative predictive value 14.29%.Conclusion:The pH test performed with reagent strips is sensitive to identify the correct placement of the gastric tube, so it can be used as an adjuvant technique in the evaluation of the gastric tube placement. In interpreting the results, pH ≤5.5 points to correct placement and values > 5.5 require radiological confirmation.

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Section: Introductionmentioning

confidence: 99%

Use of pH reagent strips to verify gastric tube placement in newborns

Dias¹,

Almeida

Álvares

et al. 2019

Rev. Latino-Am. Enfermagem

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“…Lebenthal, E by 15 weeks. [29][30][31] This variation in the time of appearance in different studies may be attributed to the age of the fetus studied or the different study techniques. But, the present observation clearly demonstrated that the initial development of circular layer occurred before 12 weeks of gestation and not later; the muscularis externa showed a craniocaudal pattern of development since the innermost oblique layer was seen at 12 weeks in cardiac region and at 14 weeks in the body region.…”

Section: Discussionmentioning

confidence: 99%

Histogenesis of developing human fetal stomach

et al. 2021

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Background: Human stomach is a highly specialised organ with distinct types of glands and microscopic features for its physiological activity. This study aimed to assess the chronological order in the development of different layers and the cyto-differentiation of various glandular cells in 50 fetuses from 12 weeks of gestation till term.Methods: Tissue was taken from cardiac, body and pylorus to investigate with light and confocal microscopy.Results: The gastric gland formation began as an indentation of the surface epithelium, gastric pit and simultaneous development of glandular buds in the mucosa. The pyloric glands preceded the development of cardiac and gastric glands showing retro cranial sequence of development. In contrast, the muscularis externa showed the classical craniocaudal model of development with oblique layer in the cardiac region by 14 weeks and body region by 16 weeks of gestation. The parietal cells were well developed by 12 weeks and the chief cells by 16 weeks with prominent secretory granules. In addition, the pyloric sphincter was a clearly defined anatomical sphincter developed by whorling of the inner circular layer at the pyloric end of the stomach evident from 12 weeks of gestation.Conclusions: The results showed that the significant cellular morphogenesis occurred between 12-20 weeks of gestation. This aggregated data will serve as a catalyst in the understanding intricacy of embryogenesis, pathogenesis tracing of congenital anomalies and invention of new drugs.

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“…Typically, term infants have low acid output initially, which becomes normal within several days. 73 regulation of postnatal nutritional adaptation is schematically represented in Figure 11 -6. Human milk is the optimal nutritional source of calcium during the first year of life. 74 Human milk also contributes trophic factors that aid digestive system maturation and immunoglobulins that reduce the risk of infection.…”

Section: Function Across the Life Spanmentioning

confidence: 99%

Vital Functions

Cech

2012

Functional Movement Development Across the Life Span

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The ontogeny and developmental physiology of gastric acid secretion

Cited by 12 publications

References 20 publications

Use of pH reagent strips to verify gastric tube placement in newborns

Use of pH reagent strips to verify gastric tube placement in newborns

Histogenesis of developing human fetal stomach

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