The ontogenetic development of the rabbit's diencephalon

Rose, Jerzy E.

doi:10.1002/cne.900770105

Cited by 160 publications

(65 citation statements)

References 12 publications

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“…The area that gives rise to the dorsal thalamus is embryologically distinct from the areas that give rise to the epithalamus and the ventral thalamic nuclei (29). The dorsal thalamus is also distinct physiologically as it corresponds to the parts of the thalamus that project to the cerebral cortex (29,30). Interestingly, this differential labeling between dorsal and ventral thalamus is not seen with the probes for NGK2-KV4 and RBK2 (compare Fig.…”

Section: Design and Preparation Of Probes For Northern Blots And Inmentioning

confidence: 92%

“…ventral lateral geniculate complex and reticular thalamic nuclei) are much weaker and in some cases within background levels. The area that gives rise to the dorsal thalamus is embryologically distinct from the areas that give rise to the epithalamus and the ventral thalamic nuclei (29). The dorsal thalamus is also distinct physiologically as it corresponds to the parts of the thalamus that project to the cerebral cortex (29,30).…”

Section: Design and Preparation Of Probes For Northern Blots And Inmentioning

confidence: 99%

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Region-specific expression of a K+ channel gene in brain.

Rudy

Kentros

Weiser

et al. 1992

Proc. Natl. Acad. Sci. U.S.A.

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Northern blot analysis and in situ hybridization studies reveal the highly localized expression in rat brain of transcripts from a gene (KShIIIA) encoding components for voltage-gated K+ channels. KShIIIA expression is particularly prominent throughout the dorsal thalamus. The expression of KShIIIA is compared to that of a closely related gene, here called NGK2-KV4. These two genes encode transcripts that induce currents in Xenopus oocytes that are as of yet indistinguishable, but they show very different patterns of expression in rat brain. NGK2-KV4 transcripts are particularly abundant in the cerebellar cortex, where KShIIMA expression is very weak. These results demonstrate the existence of cell-typespecific K+ channel components and suggest that one reason for the unusually large diversity of K+ channel proteins is the presence of subtypes that participate in specific brain functions.

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Section: Design and Preparation Of Probes For Northern Blots And Inmentioning

confidence: 92%

Section: Design and Preparation Of Probes For Northern Blots And Inmentioning

confidence: 99%

Region-specific expression of a K+ channel gene in brain.

Rudy

Kentros

Weiser

et al. 1992

Proc. Natl. Acad. Sci. U.S.A.

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“…We include the intralaminar nuclei in the medial pronucleus (not in the central, as did Rose, 1942) because of marker and phenotype similarity (see below and Discussion). All derivatives of this pronucleus expressed Gbx2 (Fig.…”

Section: Medial Pronucleus (Medial and Intralaminar Nuclear Groups)mentioning

confidence: 99%

“…These differ from each other specifically in position, morphology, marker expression, membrane properties, and cortical targets (Jones, 2007a). Thalamic subdivisions originate as five undifferentiated cell masses or pronuclei that gradually resolve into specific nuclear groups: central pronucleus (anterior, ventral, and intralaminar groups), dorsal pronucleus (lateral and posterior groups), medial pronucleus (medial group), lateral geniculate pronucleus, and medial geniculate pronucleus (Rose, 1942;Jones, 2007b).…”

Section: Introductionmentioning

confidence: 99%

The Role of Sonic Hedgehog of Neural Origin in Thalamic Differentiation in the Mouse

Szabó¹,

Zhao²,

Zhou³

et al. 2009

J. Neurosci.

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The specification of the intricate neuronal assemblies that characterize the forebrain is not well understood. The ventral spinal cord is specified through a concentration gradient of Sonic hedgehog (Shh) protein secreted by the notochord. Shh is expressed also in the forebrain neuroepithelium (neural Shh) and the underlying notochord and prechordal plate. Neural Shh is essential for the development of the prethalamus (ventral thalamus), but its effects on the thalamus (dorsal thalamus) are still unclear. We hypothesized that neural Shh would act on a previously regionalized dorsal diencephalic region to promote the emergence of specific thalamic nuclear and histological traits. To find out, we generated a conditional mouse mutant line specifically lacking Shh expression in the diencephalic neuroepithelium. We show that the transcription factor Gbx2, required for thalamic development downstream Shh, is expressed in our mutant in a restricted thalamic region and is necessary and sufficient for the differentiation of the medial and intralaminar thalamic nuclei. In the rest of the thalamus, neural Shh is required to promote neuronal aggregation into nuclei as well as axonal extension. In this way, the individual thalamic nuclei show differential dependence on Shh, Gbx2, or both for their differentiation. Additionally, Gbx2 is required for the survival of thalamic neurons.

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“…The TRN develops from the ventral thalamus / 84,140 / forming a thin veil that covers most of the dorsal thalamus along its entire antero-posterior extent and separates it from the cortex (Figs. 1, 2A).…”

Section: Features Of Trn Anatomy and Cellular Architecturementioning

confidence: 99%

Circuits for Multisensory Integration and Attentional Modulation Through the Prefrontal Cortex and the Thalamic Reticular Nucleus in Primates

Zikopoulos

Barbas²

2007

Reviews in the Neurosciences

131

111

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Converging evidence from anatomic and physiologic studies suggests that the interaction of highorder association cortices with the thalamus is necessary to focus attention on a task in a complex environment with multiple distractions. Interposed between the thalamus and cortex, the inhibitory thalamic reticular nucleus intercepts and regulates communication between the two structures. Recent findings demonstrate that a unique circuitry links the prefrontal cortex with the reticular nucleus and may underlie the process of selective attention to enhance salient stimuli and suppress irrelevant stimuli in behavior. Unlike other cortices, some prefrontal areas issue widespread projections to the reticular nucleus, extending beyond the frontal sector to the sensory sectors of the nucleus and may influence the flow of sensory information from the thalamus to the cortex. Unlike other thalamic nuclei, the mediodorsal nucleus, which is the principal thalamic nucleus for the prefrontal cortex, has similarly widespread connections with the reticular nucleus. Unlike sensory association cortices, some terminations from prefrontal areas to the reticular nucleus are large, suggesting efficient transfer of information. We propose a model showing that the specialized features of prefrontal pathways in the reticular nucleus may allow selection of relevant information and override distractors, in processes that are deranged in schizophrenia.

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The ontogenetic development of the rabbit's diencephalon

Cited by 160 publications

References 12 publications

Region-specific expression of a K+ channel gene in brain.

Region-specific expression of a K+ channel gene in brain.

The Role of Sonic Hedgehog of Neural Origin in Thalamic Differentiation in the Mouse

Circuits for Multisensory Integration and Attentional Modulation Through the Prefrontal Cortex and the Thalamic Reticular Nucleus in Primates

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