The ontogenesis of language lateralization and its relation to handedness

Ocklenburg, Sebastian; Beste, Christian; Arning, Larissa; Peterburs, Jutta; Güntürkün, Onur

doi:10.1016/j.neubiorev.2014.04.008

Cited by 129 publications

(98 citation statements)

References 103 publications

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“…Admittedly, these handedness differences are frequently weak (e.g. Bless et al, 2015;Brysbaert, 1994;Ocklenburg et al, 2014) or do not occurr at all (e.g. Chiarello et al, 1984).…”

Section: Discussionmentioning

confidence: 99%

“…As summarized recently, "Empirically, there are no other processes that have produced such reliable differences between the hemispheres as experiments on language (e.g., lexical decision) and spatial (e.g., mental rotation) tasks" (Hugdahl, 2000, p. 217). While the origins of functional hemispheric specialization (including handedness) remain to be determined (Bradshaw, 1988;Hugdahl, 2000;Ocklenburg, Beste, Arning, Peterburs, & Güntürkün, 2014) studies that assess its stability (Blumstein, Goodglass, & Tartter, 1975;Chiarello, Dronkers, & Hardyck, 1984;Teng, 1981;Voyer, 2003), short-term and longterm fluctuations (Bayer & Hausmann, 2009;Cabeza, 2002;Hausmann & Gunturkun, 2000;Mohr, Michel, et al, 2005), clinical relationships (Eyler, Pierce, & Courchesne, 2012;Grimshaw & Carmel, 2014;Mitchell & Crow, 2005) and individual difference relationships (Hausmann & Gunturkun, 1999;Mikheev, Mohr, Afanasiev, Landis, & Thut, 2002;Nicholls, Orr, & Lindell, 2005) require that its experimental assessment is reliable and valid (Voyer, 1998).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Stability of right visual field advantage in an international lateralized lexical decision task irrespective of participants’ sex, handedness or bilingualism

Willemin

Hausmann

Brysbaert³

et al. 2016

Laterality: Asymmetries of Body, Brain and Cognition

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Additional information:Use policyThe full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-pro t purposes provided that:• a full bibliographic reference is made to the original source • a link is made to the metadata record in DRO • the full-text is not changed in any way The full-text must not be sold in any format or medium without the formal permission of the copyright holders.Please consult the full DRO policy for further details. Willemin, J., Hausmann, M., Brysbaert, M., Dael, N., Chmetz, F., Fioravera, A., Gieruc, K., Mohr, C. (2016). Stability of right visual field advantage in an international lateralized lexical decision task irrespective of participants' sex, handedness or bilingualis. AbstractIn lateralized lexical decision tasks, accuracy is higher and reaction times are faster for right visual field (RVF) than left visual field (LVF) presentations. Visual field differences are thought to demonstrate the left hemisphere's dominance for language.The use of different tasks and words between studies and languages make direct comparisons difficult. We performed a lateralized lexical decision task for which we selected 4-6 letter words that are used in three languages of Switzerland (French, German, and Italian) and English and Dutch. We accounted for the potential moderating roles of sex, handedness, and multilingualism (early acquisition versus late acquisition of at least one second language). One hundred participants were tested at a French-speaking University in Switzerland. All performed a French vocabulary knowledge task (Brysbaert, 2013). Results showed a RVF over LVF advantage (accuracy, reaction times, signal detection theory measures) for all groups, i.e. irrespective of participants' sex, handedness and how many languages they spoke. We observed, however, that enhanced vocabulary knowledge related to a right hemisphere shift in early bilinguals and a left hemisphere shift in late bilinguals. We discuss how the current observations can inform future studies suitable for the validation of the current task using an "international"vocabulary.

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“…Admittedly, these handedness differences are frequently weak (e.g. Bless et al, 2015;Brysbaert, 1994;Ocklenburg et al, 2014) or do not occurr at all (e.g. Chiarello et al, 1984).…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Stability of right visual field advantage in an international lateralized lexical decision task irrespective of participants’ sex, handedness or bilingualism

Willemin

Hausmann

Brysbaert³

et al. 2016

Laterality: Asymmetries of Body, Brain and Cognition

View full text Add to dashboard Cite

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“…Along these lines, research linking handedness to the development of dyslexia is now progressing and dyslexia-candidate genes have been discovered to play a role in the biological mechanisms that establish left-right asymmetry of the body and influence handedness [42]. Nevertheless, as Ocklenburg et al [43] point out, the ontogenetic relationship of handedness to lateralization of language (and, by extrapolation, dyslexia) is multifactorial and complex.…”

Section: Limb Preference and Performancementioning

confidence: 99%

A Matter of Degree: Strength of Brain Asymmetry and Behaviour

Rogers

2017

Symmetry

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Abstract:Research on a growing number of vertebrate species has shown that the left and right sides of the brain process information in different ways and that lateralized brain function is expressed in both specific and broad aspects of behaviour. This paper reviews the available evidence relating strength of lateralization to behavioural/cognitive performance. It begins by considering the relationship between limb preference and behaviour in humans and primates from the perspectives of direction and strength of lateralization. In birds, eye preference is used as a reflection of brain asymmetry and the strength of this asymmetry is associated with behaviour important for survival (e.g., visual discrimination of food from non-food and performance of two tasks in parallel). The same applies to studies on aquatic species, mainly fish but also tadpoles, in which strength of lateralization has been assessed as eye preferences or turning biases. Overall, the empirical evidence across vertebrate species points to the conclusion that stronger lateralization is advantageous in a wide range of contexts. Brief discussion of interhemispheric communication follows together with discussion of experiments that examined the effects of sectioning pathways connecting the left and right sides of the brain, or of preventing the development of these left-right connections. The conclusion reached is that degree of functional lateralization affects behaviour in quite similar ways across vertebrate species. Although the direction of lateralization is also important, in many situations strength of lateralization matters more. Finally, possible interactions between asymmetry in different sensory modalities is considered.

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“…Since CNTNAP2 plays roles in brain development (Graham & Fisher, 2013;Rodenas-Cuadrado et al, 2014), it is interesting to note that the dorsal stream has been observed as particularly susceptible to damage during early development (Braddick et al, 2003;Grinter et al, 2010) and that genetic influences are greatest on brain regions which mature early, exemplified by the occipital lobe (Brun et al, 2009). Brain lateralization similarly begins early in development (Francks, 2015), and our lateralized finding in LSOG might add to discussions about the neurogenetics of language lateralization (Ocklenburg, Beste, Arning, Peterburs, & Gunturkun, 2014). There are a number of lateralized functional accounts of the dorsal visual stream (including LSOG and the left intraparietal sulcus) in relation to aspects of language processing.…”

Section: Discussionmentioning

confidence: 55%

A common variant of the CNTNAP2 gene is associated with structural variation in the left superior occipital gyrus

et al. 2017

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a b s t r a c tThe CNTNAP2 gene encodes a cell-adhesion molecule that influences the properties of neural networks and the morphology and density of neurons and glial cells. Previous studies have shown association of CNTNAP2 variants with language-related phenotypes in health and disease. Here, we report associations of a common CNTNAP2 polymorphism (rs7794745) with variation in grey matter in a region in the dorsal visual stream. We tried to replicate an earlier study on 314 subjects by Tan et al. (2010), but now in a substantially larger group of more than 1700 subjects. Carriers of the T allele showed reduced grey matter volume in left superior occipital gyrus, while we did not replicate associations with grey matter volume in other regions identified by Tan et al. (2010). Our work illustrates the importance of independent replication in neuroimaging genetic studies of language-related candidate genes.

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The ontogenesis of language lateralization and its relation to handedness

Cited by 129 publications

References 103 publications

Stability of right visual field advantage in an international lateralized lexical decision task irrespective of participants’ sex, handedness or bilingualism

Stability of right visual field advantage in an international lateralized lexical decision task irrespective of participants’ sex, handedness or bilingualism

A Matter of Degree: Strength of Brain Asymmetry and Behaviour

A common variant of the CNTNAP2 gene is associated with structural variation in the left superior occipital gyrus

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