The onset of puberty in female mice as reflected in urinary steroids and uterine/ovarian mass: interactions of exposure to males, phyto-oestrogen content of diet, and ano-genital distance

Khan, Ayesha; Berger, Robert; deCatanzaro, Denys

doi:10.1530/rep-07-0314

Cited by 16 publications

(10 citation statements)

References 51 publications

(66 reference statements)

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“…There appears to be a strong relationship between urine progesterone and PDG, suggesting a relatively simple, though crude, transformation that links the 2 values (Stanczyk et al 1997, Falk et al 1999. The urine progesterone values were similar to other mammals (Herrick et al 2000, Khan et al 2008) and comparable to the transformed PDG values reported in other cetaceans (Robeck et al 2004(Robeck et al , 2005. Urine data was available for only 2 demographic groups in the present study: immature males and immature females.…”

Section: Urine Progesteronesupporting

confidence: 86%

Variation of bowhead whale progesterone concentrations across demographic groups and sample matrices

Kellar

Keliher²,

Trego³

et al. 2013

Endang. Species. Res.

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Bowhead whale Balaena mysticetus progesterone concentrations were measured in different sample matrices (serum, blubber, and urine) to investigate (1) concordance among sample type and (2) variation among life-history class. Samples were collected from subsistencehunted whales (n = 86) taken from 1999 to 2009. In general, irrespective of sample matrix, pregnant females had the highest concentrations by orders of magnitude, followed by mature animals of both sexes, and subadults had the lowest concentrations. Subadult males and females had similar progesterone concentrations in all sample matrices measured. When pregnant animals were included in our analyses, permuted regression models indicated a strong positive relationship between serum and blubber progesterone levels (r 2 = 0.894, p = 0.0002). When pregnant animals were not included, we found no significant relationship between serum and blubber levels (r 2 = 0.025, p = 0.224). These results suggest that progesterone concentrations are mirrored in these sample types over longer periods (i.e. on the order of weeks to months, time frame of reproductive changes) but not shorter periods (i.e. on the order of hours to days, time frame of daily fluctuations). This conclusion is consistent even for progesterone concentrations measured in females that had recently changed pregnancy states (either new mothers or newly pregnant animals), for which blubber progesterone levels seem to lag those in the serum. Finally, urine progesterone had statistically significant positive relationships with serum (r 2 = 0.136, p = 0.0460) and blubber progesterone (r 2 = 0.150, p = 0.0421). Our results suggest that progesterone concentrations first peak in the serum, then in the urine, and finally in the blubber.

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Section: Urine Progesteronesupporting

confidence: 86%

Variation of bowhead whale progesterone concentrations across demographic groups and sample matrices

Kellar

Keliher²,

Trego³

et al. 2013

Endang. Species. Res.

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“…This suggests that weight is a poor indicator of age. Furthermore, housing males in close proximity to females can accelerate the onset of female puberty (Khan et al 2008; Vandenbergh 1967; Vandenbergh et al 1976). Overall, there are many social and environmental determinants of the highly variable onset of puberty.…”

Section: Adolescence and Relevant Maturationmentioning

confidence: 99%

Stress in adolescence and drugs of abuse in rodent models: Role of dopamine, CRF, and HPA axis

2013

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Rationale Research on adolescence and drug abuse increased substantially in the past decade. However, drug-addiction related behaviors following stressful experiences during adolescence are less studied. We focus on rodent models of adolescent stress cross-sensitization to drugs of abuse. Objectives Review the ontogeny of behavior, dopamine, corticotropin-releasing factor (CRF), and the hypothalamic pituitary adrenal (HPA) axis in adolescent rodents. We evaluate evidence that stressful experiences during adolescence engender hypersensitivity to drugs of abuse and offer potential neural mechanisms. Results and Conclusions Much evidence suggests that final maturation of behavior, dopamine systems, and HPA axis occurs during adolescence. Stress during adolescence increases amphetamine- and ethanol-stimulated locomotion, preference, and self-administration under many conditions. The influence of adolescent stress on subsequent cocaine- and nicotine-stimulated locomotion and preference is less clear. The type of adolescent stress, temporal interval between stress and testing, species, sex, and the drug tested are key methodological determinants for successful cross-sensitization procedures. The sensitization of the mesolimbic dopamine system is proposed to underlie stress cross-sensitization to drugs of abuse in both adolescents and adults through modulation by CRF. Reduced levels of mesocortical dopamine appear to be a unique consequence of social stress during adolescence. Adolescent stress may reduce the final maturation of cortical dopamine through D2 dopamine receptor regulation of dopamine synthesis or glucocorticoid-facilitated pruning of cortical dopamine fibers. Certain rodent models of adolescent adversity are useful for determining neural mechanisms underlying the cross-sensitization to drugs of abuse.

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“…However, other evidence has shown that a male's preputial glands are not necessary for his ability to induce growth of the female's uterus and ovaries ). It is likely that there are convergent mechanisms that may each be sufficient and that multiple triggers are involved in various physiological and behavioural measures of female reproductive maturation (Vandenbergh 1967, Bronson & Desjardins 1974, Khan et al 2008a. Our data implicating male urinary E 2 in the Vandenbergh effect are specific to measures of uterine growth, and further research would be necessary to generalise our hypothesised mechanism to other measures of reproductive maturity.…”

Section: Discussionmentioning

confidence: 74%

“…This phyto-oestrogen-free diet contains !10.0 ppm total isoflavones (aglycone equivalents of genistein, daidzein and glycitein). Ingredients of the two diets are previously described (Khan et al 2008a). After at least 2 months on their respective diets, males were exposed to juvenile females and recently inseminated females in the exposure apparatus using protocols described below.…”

Section: Comparison Of Males On Soy-based and Phyto-oestrogenfree Dietsmentioning

confidence: 99%

“…A preliminary experiment was designed to compare the capacities of males to induce the Vandenbergh and Bruce effects when they were fed either a common laboratory soy-based diet or a phytooestrogen-free diet. This was based on evidence that dietary phyto-oestrogens can influence measures of urinary E 2 and possibly the Bruce effect (Beaton & deCatanzaro 2005) and evidence that they can also influence female reproductive maturation (Whitten & Naftolin 1992, Thigpen et al 2003, Khan et al 2008a. Subsequent experiments were conducted with all males on a phyto-oestrogen-free diet, used several weeks after castration in order to diminish baseline urinary testosterone and E 2 (Vella & deCatanzaro 2001).…”

Section: Introductionmentioning

confidence: 99%

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Oestradiol treatment restores the capacity of castrated males to induce both the Vandenbergh and the Bruce effects in mice (Mus musculus)

Thorpe¹,

deCatanzaro²

2012

Reproduction

Self Cite

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Androgen-dependent urinary constituents from males hasten reproductive maturation (the Vandenbergh effect) and disrupt periimplantation pregnancy (the Bruce effect) in nearby females. Each of these effects can be mimicked in socially isolated females by direct administration of exogenous oestrogens. The current experiments were designed to determine the role of males' urinary 17b-oestradiol (E 2 ) in their capacities to induce these effects. A preliminary experiment showed that both males on a phyto-oestrogen-rich soy-based diet and those on a phyto-oestrogen-free diet could induce both effects. For subsequent experiments, males were castrated and treated with either oil vehicle or E 2 . Enzyme immunoassay was conducted on non-invasively collected urine samples from these males. Concentrations of urinary testosterone were subnormal in both conditions, but urinary E 2 was restored to the normal range for intact males in castrates given E 2 . Urinary creatinine was also quantified as a measure of hydration and was significantly reduced in males treated with E 2 . Castration diminished the capacity of males to promote growth of the immature uterus and also their capacity to disrupt blastocyst implantation in inseminated females. Injections of E 2 to castrated males restored both capacities. These data converge with other studies indicating that E 2 is the main constituent of male urine responsible for induction of both the Vandenbergh and the Bruce effects.

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The onset of puberty in female mice as reflected in urinary steroids and uterine/ovarian mass: interactions of exposure to males, phyto-oestrogen content of diet, and ano-genital distance

Cited by 16 publications

References 51 publications

Variation of bowhead whale progesterone concentrations across demographic groups and sample matrices

Variation of bowhead whale progesterone concentrations across demographic groups and sample matrices

Stress in adolescence and drugs of abuse in rodent models: Role of dopamine, CRF, and HPA axis

Oestradiol treatment restores the capacity of castrated males to induce both the Vandenbergh and the Bruce effects in mice (Mus musculus)

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