The One Health approach to incident management of the 2019 Lassa fever outbreak response in Nigeria

Nwafor, Chioma Dan; Ilori, Elsie; Olayinka, Adebola; Ochu, Chinwe Lucia; Olorundare, Rosemary; Edeh, Edwin; Okwor, Tochi; Oyebanji, Oyeronke; Namukose, Esther M.; Ukponu, Winifred; Olugbile, Michael; Adekanye, Usman; Chandra, Nastassya; Bolt, Hikaru; Namara, Geofrey; Ipadeola, Oladipupo; Furuse, Yuki; Woldetsadik, Solomon Fisseha; Akano, Adejoke; Iniobong, Akanimo; Amedu, Michael; Anueyiagu, Chimezie; Bakare, Lawal; Ahumibe, Anthony; Joseph, Gbenga; Eneh, Chibuzo; Saleh, Muhammad Muhammad; Naidoo, Dhamari; Okoli, Ihekerenma; Kachalla, Mairo; Okea, Rita A; Okenyi, Collins; Makava, Favour; Makwe, Catherine; Ugbogulu, Nkem; Fonkeng, Fritz; Aniaku, Everistus; Agogo, Emmanuel; Nwando,; Aruna, Olusola; Nguku, Patrick; Ihekweazu, Chikwe

doi:10.1016/j.onehlt.2021.100346

Cited by 6 publications

(2 citation statements)

References 11 publications

(13 reference statements)

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“…Cases occur round the year but there is a notable seasonal peak during the dry season. Important hotspot states for these outbreaks include Edo, Ondo and Ebonyi states [9,10]. The increasing number of cases has also significantly led to increasing mortality rate due to lassa fever [11].…”

Section: The Annual Incidence Of Lf In Endemic Westmentioning

confidence: 99%

Knowledge, Attitude and Prevention of Lassa fever Transmission among Women in Nnewi North Lga, Anambra State, Nigeria

Areji,

Onyenemezu,

Ubah

et al. 2023

IJTDH

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Purpose: Lassa fever is a disease of public health concern associated with significant morbidity and mortality. It is noted to be endemic in the west-African Lassa fever belt with seasonal variations usually associated with epidemics. Nigeria among other countries is known to suffer from this. This study aims to determine the Knowledge, attitude, and prevention of Lassa Fever transmission among women in Nnewi North LGA of Anambra State and contributory factors. Methodology: A cross-sectional study conducted among women in Nnewi between 1st to 30th September, 2022. Data was collected using pretested interviewer-administered questionnaire among 252 respondents. It was analyzed with SPSS version 25.0. Results: Their mean age was 33.40 years ranging from 18-69 years. Overall, 80.2% of the respondents had good knowledge on Lassa fever, 77.8% had good attitude towards prevention and 84.9% showed a good level of practice of its prevention. Educational level was a statistically significant factor in all these. 21% of respondents reported knowledge through health workers. Conclusion: There is a high level of knowledge, attitude, and transmission prevention among women resident in Nnewi with educational status being a major determinant. This will significantly help to reduce the burden of and transmission of the disease though the means of awareness differed among different individuals. Practical Implication: There is a need to improve public health awareness by health workers in order to improve the integrity and content of the population’s health education.

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Section: The Annual Incidence Of Lf In Endemic Westmentioning

confidence: 99%

Knowledge, Attitude and Prevention of Lassa fever Transmission among Women in Nnewi North Lga, Anambra State, Nigeria

Areji,

Onyenemezu,

Ubah

et al. 2023

IJTDH

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“…(McCormick and Fisher-Hoch, 2002;Lassa Fever | CDC, 2022) In addition to endemic Lassa fever in West Africa, there is currently an outbreak of Lassa fever in Nigeria dating back to 2019 with a case fatality rate hovering around 20%. (Nwafor et al, 2021) LASV is on the Health and Human Services Select Agents and Toxins list as it poses a severe threat to human health and is listed on the World Health Organizations list of priority pathogens with the potential to cause outbreaks or pandemics. ("Prioritizing Diseases for Research and Development in Emergency Contexts" 2023; "HHS and USDA Select Agents and Toxins: 7 CFR Part 331, 9 CFR Part 121, and 42 CFR Part 73," 2023) It is also classified as a Centers for Disease Control and Prevention Category A bioterrorism agent because it can be transmitted from person-to-person, can have a high mortality rate giving it the potential for a major public health impact, may cause panic and social disruption, and requires special action for public health preparedness.…”

Section: Introductionmentioning

confidence: 99%

An atlas of gross and histologic lesions and immunohistochemical immunoreactivity during the temporal progression of aerosolized Lassa virus induced hemorrhagic fever in cynomolgus macaques

Bohler,

Cashman,

Wilkinson

et al. 2024

Front. Cell. Infect. Microbiol.

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Lassa virus (LASV) causes an acute multisystemic hemorrhagic fever in humans known as Lassa fever, which is endemic in several African countries. This manuscript focuses on the progression of disease in cynomolgus macaques challenged with aerosolized LASV and serially sampled for the development and progression of gross and histopathologic lesions. Gross lesions were first noted in tissues on day 6 and persisted throughout day 12. Viremia and histologic lesions were first noted on day 6 commencing with the pulmonary system and hemolymphatic system and progressing at later time points to include all systems. Immunoreactivity to LASV antigen was first observed in the lungs of one macaque on day 3 and appeared localized to macrophages with an increase at later time points to include immunoreactivity in all organ systems. Additionally, this manuscript will serve as a detailed atlas of histopathologic lesions and disease progression for comparison to other animal models of aerosolized Arenaviral disease.

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Chancen der Digitalisierung im Epidemie-Management – eine persönliche Sicht

Krause

2022

Infektionen Und Gesellschaft

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The One Health approach to incident management of the 2019 Lassa fever outbreak response in Nigeria

Cited by 6 publications

References 11 publications

Knowledge, Attitude and Prevention of Lassa fever Transmission among Women in Nnewi North Lga, Anambra State, Nigeria

Knowledge, Attitude and Prevention of Lassa fever Transmission among Women in Nnewi North Lga, Anambra State, Nigeria

An atlas of gross and histologic lesions and immunohistochemical immunoreactivity during the temporal progression of aerosolized Lassa virus induced hemorrhagic fever in cynomolgus macaques

Chancen der Digitalisierung im Epidemie-Management – eine persönliche Sicht

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