2021
DOI: 10.1016/j.abb.2021.108811
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The oncogenic role of ubiquitin specific peptidase (USP8) and its signaling pathways targeting for cancer therapeutics

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Cited by 39 publications
(40 citation statements)
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“…Increasing studies have revealed that the elevated expression of human USP8 correlates with tumorigenesis, including proliferation and metastasis [ 34 ]. USP8 promotes the progression of breast cancer via deubiquitinating and stabilizing Connexin-43 (Cx43) and Notch1 intracellular domain (NICD) [ 24 , 35 ].…”
Section: Discussionmentioning
confidence: 99%
“…Increasing studies have revealed that the elevated expression of human USP8 correlates with tumorigenesis, including proliferation and metastasis [ 34 ]. USP8 promotes the progression of breast cancer via deubiquitinating and stabilizing Connexin-43 (Cx43) and Notch1 intracellular domain (NICD) [ 24 , 35 ].…”
Section: Discussionmentioning
confidence: 99%
“…USP8, a deubiquitinase, counters NRDP1 autoubiquitination and thereby increases NRDP1 levels [32]. Inhibition of USP8 has been shown to decrease NRDP1 levels and decrease cell proliferation and drug resistance in several cancers including breast, lung, and cervical cancer [47]. For example, knockdown of USP8 in lung cancer cells inhibited the proliferation of lung cancer cells by regulating several cell cycle and apoptosis-related proteins [48].…”
Section: Discussionmentioning
confidence: 99%
“…Ubiquitin-specific proteases (USPs) as a deubiquitinases, regulate multiple fundamental cellular processes including cell proliferation, cell cycle, and cancer progression by removing ubiquitin from the substrate proteins [ 1 , 2 ]. However, recent evidences have demonstrated that ubiquitin specific peptidase 8 (USP8) stabilizes oncogenes and proto-oncogenes, therefore promoting cancer progression and survival through the activation of multiple signaling pathways [ 1 , 3 , 4 ]. It is critically associated with the movement of the ubiquitin from oncogenes and proto-oncogenes, and thus protect the proteins from degradation [ 3 , 4 ].…”
Section: Introductionmentioning
confidence: 99%
“…However, recent evidences have demonstrated that ubiquitin specific peptidase 8 (USP8) stabilizes oncogenes and proto-oncogenes, therefore promoting cancer progression and survival through the activation of multiple signaling pathways [ 1 , 3 , 4 ]. It is critically associated with the movement of the ubiquitin from oncogenes and proto-oncogenes, and thus protect the proteins from degradation [ 3 , 4 ]. Depending with the ubiquitination linkages, the ubiquitinated substrate proteins can either play part in the regulation of protein degradation pathway, like in the case of K48-linkage ubiquitination, or functional regulation of cellular signaling, like in the case of K63-linkage ubiquitination [5] , [6] , [7] .…”
Section: Introductionmentioning
confidence: 99%