The oncogenetic landscape and clinical impact of <i>BCL11B</i> alterations in adult and pediatric T-cell acute lymphoblastic leukemia

Abstract

Not available.

T‐cell lymphoma patient harboring BCL11B mutations had favorable overall survival

“…or MDS, the reason is thought that lower BCL11B related lower T cell activity. 18,36 In contrast, BCL11B is also considered as oncogene in T-ALL, 22,37 overexpression of BCL11B is frequently identified in T-ALL, inhibition of BCL11B effectively induces growth retardation and apoptosis of T-ALL cells. [22][23][24]38,39 These findings were consistent with present study that TCL patients harboring BCL11B mutation might predict favorable prognosis.…”

BCL11B Mutations Are Associated with Higher CD8+ T-Cell Percentage and Favorable Clinical Outcomes in Patients with T-Cell Acute Lymphoblastic Leukemia

“…These results were consistent with a previous report. 10 However, patients with T-ALL harboring a missense mutation of BCL11B which was the most common type of mutation had a lower percentage of CR (42.9% vs 88.2%, P < .001) and negative MRD (38.5% vs 58.3%, P = .173) (Figure S2). Therefore, CR or MRD was not associated with the most common type of mutation, but rather positively correlated with the overall BCL11B mutation.…”

“…Therefore, the prognostic value in this study was similar to the published articles on different types of diseases. 9 Moreover, a previous report found that BCL11B mutations predict better OS and event-free survival for patients with adult and pediatric T-ALL and may be a potential biomarker for risk stratification in T-ALL 10 ; the relationship between BCL11B mutations and T cells in T-ALL, and the prognostic importance, still remains unclear.…”

“…The mutation rate of BCL11B was 14.4% (107/741) in adult and pediatric T-ALL ( Figure 1A and Table S1), which was consistent with a previous study (18%). 10 The hotspot mutation site of BCL11B was zf-H2C2-2 ( Figure 1A ). The types of mutations included missense, frameshift insertion, non-frameshift insertion, nonsense, frameshift deletion, non-frameshift deletion, and splice site mutation.…”