The Oncogene Metadherin Modulates the Apoptotic Pathway Based on the Tumor Necrosis Factor Superfamily Member TRAIL (Tumor Necrosis Factor-related Apoptosis-inducing Ligand) in Breast Cancer

Zhang, Ning; Wang, Xiaolong; Huo, Qiang; Li, Xiaoyan; Wang, Huiyun; Schneider, Pascal; Hu, Guohong; Yang, Qifeng

doi:10.1074/jbc.m112.395913

Cited by 37 publications

(31 citation statements)

References 43 publications

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“…By contrast, at 10 and 20 µM SM, the apoptosis rate was identified to be significantly different compared with the control group (P<0.001). In order to clarify the exact mechanism of apoptosis in hepatoma cells, the expression levels of Bcl-2 family proteins and caspases were examined (33,34). Bcl-2 family proteins play a crucial role in the mitochondrial apoptosis pathway, and the Bax/Bcl-2 ratio reflects a close association to the extent of apoptosis (35,36).…”

Section: Discussionmentioning

confidence: 99%

Solamargine triggers hepatoma cell death through apoptosis

et al. 2015

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Abstract. Solamargine (SM), a steroidal alkaloid glycoside extracted from the traditional Chinese herb Solanum incanum, has been evidenced to inhibit the growth and induce apoptosis in a number of human cancer cell lines. In the present study, the anticancer effect of SM and underlying molecular mechanism of SM-induced apoptosis were investigated on the human hepatocellular carcinoma cells, SMMC7721 and HepG2. The proliferation effects of SM on the SMMC7721 and HepG2 cell lines were evaluated using MTT and colony formation assays. In addition, the percentage of apoptosis was measured using an Annexin V/propidium iodide staining method and the cell cycle distribution mediated by SM was analyzed using flow cytometry. The expression levels of B-cell lymphoma-2 (Bcl-2), Bcl-2-associated X protein (Bax), caspase-3, caspase-9, proliferating cell nuclear antigen (pcna) and Ki67 proteins were examined to further demonstrate the proliferate and apoptosis effects of SM on the hepatoma cells. The results indicated that SM effectively inhibited hepatoma cell proliferation and promoted apoptosis. SM resulted in cell cycle arrest at the G 2 /M phase in the two cell lines. In addition, SM downregulated the levels of proliferation-associated (Ki67 and pcna) and anti-apoptotic (Bcl-2) proteins, and promoted the activity of apoptosis-associated proteins (Bax, caspase-3 and caspase-9). Therefore, the activation of the Bcl-2/Bax and caspase signaling pathways may be involved in the SM-induced apoptosis of hepatoma cells.

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Section: Discussionmentioning

confidence: 99%

Solamargine triggers hepatoma cell death through apoptosis

et al. 2015

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“…MTDH could mediate drug resistance in various cancers30 as suggested by Meng et al . For reproduction malignancies, it was reported that inhibition of MTDH increases cancer cells’ sensitivity to chemotherapy drugs, such as AZD6244, tumor necrosis factor-a-related apoptosis-inducing ligand (TRAIL) and HDAC inhibitor LBH589313233. Interestingly, Zhao Y et al .…”

Section: Discussionmentioning

confidence: 99%

Association of MTDH immunohistochemical expression with metastasis and prognosis in female reproduction malignancies: a systematic review and meta-analysis

Hou

Yonghua

et al. 2016

Sci Rep

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Various literatures have demonstrated that overexpression of Metadherin (MTDH) is correlated with tumor metastasis and it can predict poor survival outcomes in female reproduction malignancies. In order to enhance the statistical power and reach a recognized conclusion, we conducted a systematic review and meta-analysis to thoroughly investigate the association of MTDH expression with tumor metastasis and survival outcomes following PRISMA guidelines. Odds ratios (ORs) and hazard ratios (HRs) were used to demonstrate the impact of MTDH on tumor metastasis and prognosis respectively. Data were pooled with appropriate effects model on STATA12.0. Our results indicated that high MTDH expression is significantly correlated with higher mortality for breast, ovarian and cervical cancer. High immunohistochemical expression of MTDH is remarkably associated with shorter disease-free survival (DFS) in breast cancer but not in ovarian cancer. The pooled results suggested that high level of MTDH significantly predicted distant metastasis and lymph node metastasis in breast cancer. Strong associations were observed between MTDH expression and lymph node metastasis in ovarian and cervical cancer. In conclusion, MTDH might be a novel biomarker which can effectively reflect metastasis status and prognosis of breast cancer. However, its application in clinical practice needs more prospective studies with large samples.

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“…TRAIL expression activates immune cells through thyroid autoantigen generation, in order to generate IFN-γ and TNF-α. The synergic induction of IFN-γ and TNF-α results in the expression of TRAIL by thyroid cells, increasing the sensitivity of TRAIL on immune cells, and ultimately resulting in apoptosis (27). Furthermore, TNF-α and IL-1 may result in the destruction of thyroid cells.…”

Section: Discussionmentioning

confidence: 99%

“…At present, TRAIL is considered to result in apoptosis through activation of immune cells, leading to generation of TNF-α and IL-1 (24). TNF-α and IL-1 have a synergistic effect that improves thyroid cell sensitivity of TRAIL, resulting in the death of thyroid cells (27). TRAIL expression activates immune cells through thyroid autoantigen generation, in order to generate IFN-γ and TNF-α.…”

Section: Discussionmentioning

confidence: 99%

Neuroprotective effect of (‑)‑epigallocatechin‑3‑gallate on autoimmune thyroiditis in a rat model by an anti‑inflammation effect, anti‑apoptosis and inhibition of TRAIL signaling pathway

2017

Exp Ther Med

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Abstract. (-)-Epigallocatechin-3-gallate (EGCG) is a polyphenol monomer compound extracted and separated from green tea, and is a key catechin in green tea. Recent research has identified that EGCG is equipped with important biological activities, including antitumor, antioxidant, anti-inflammation, blood fat reduction and radiation protection abilities. In the current study, it was investigated whether EGCG exerts a neuroprotective effect on AIT and examined the possible underlying mechanism. The present study sought to establish an experimental autoimmune thyroiditis (AIT) rat model and to investigate the neuroprotective effect of EGCG in this model. EGCG was demonstrated to inhibit urinary iodine values and thyroid pathological features in AIT model rats. Treatment with EGCG significantly reduced interleukin-1β, interferon-γ (INF-γ) and tumor necrosis factor-α (TNF-α) levels in the AIT rats through suppression of nuclear factor-κB (NF-κB) pathway. In addition, pretreatment with EGCG significantly increased B-cell lymphoma-2 protein expression, and suppressed caspase-3 activity and TNF-α-related apoptosis-inducing ligand (TRAIL) protein expression levels in the AIT model rats. In conclusion, these results suggested that the neuroprotective effect of EGCG protects against AIT through its anti-inflammatory ability, anti-apoptosis and TRAIL signaling pathway in model rats, and it may be used as a therapeutic agent against AIT caused by inflammation.

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The Oncogene Metadherin Modulates the Apoptotic Pathway Based on the Tumor Necrosis Factor Superfamily Member TRAIL (Tumor Necrosis Factor-related Apoptosis-inducing Ligand) in Breast Cancer

Cited by 37 publications

References 43 publications

Solamargine triggers hepatoma cell death through apoptosis

Solamargine triggers hepatoma cell death through apoptosis

Association of MTDH immunohistochemical expression with metastasis and prognosis in female reproduction malignancies: a systematic review and meta-analysis

Neuroprotective effect of (‑)‑epigallocatechin‑3‑gallate on autoimmune thyroiditis in a rat model by an anti‑inflammation effect, anti‑apoptosis and inhibition of TRAIL signaling pathway

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