The on-off action of Forkhead protein O3a in endotoxin tolerance of Kupffer cells depends on the PI3K/AKT pathway

Mu, Di; Miao, Chun-Mu; Cheng, Yao; Li, Peizhi; Gong, Jianping; Zhang, Wenfeng

doi:10.1016/j.intimp.2020.106342

Cited by 2 publications

(2 citation statements)

References 38 publications

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“…PI3K/AKT signaling activation and EBV lytic induction responded to IL-10 knockdown (Gao et al, 2019). In addition, Mu et al (2020) found that the PI3K agonist impaired the tolerance of Kupffer cells FIGURE 7 | The effect of IL10RA on cell proliferation in vitro using CCK8 assays after downregulating IL10RA in A375 (A) and B16-F10 (B) cells. * P < 0.05, * * P < 0.01, * * * P < 0.001.…”

Section: Il10ra Potentially Mediates In Metastatic Melanoma Via Pi3k-mentioning

confidence: 99%

Identification of IL10RA by Weighted Correlation Network Analysis and in vitro Validation of Its Association With Prognosis of Metastatic Melanoma

Cheng

Zhang

et al. 2021

Front. Cell Dev. Biol.

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Skin cutaneous melanoma (SKCM) is the major cause of death for skin cancer patients, its high metastasis often leads to poor prognosis of patients with malignant melanoma. However, the molecular mechanisms underlying metastatic melanoma remain to be elucidated. In this study we aim to identify and validate prognostic biomarkers associated with metastatic melanoma. We first construct a co-expression network using large-scale public gene expression profiles from GEO, from which candidate genes are screened out using weighted gene co-expression network analysis (WGCNA). A total of eight modules are established via the average linkage hierarchical clustering, and 111 hub genes are identified from the clinically significant modules. Next, two other datasets from GEO and TCGA are used for further screening of biomarker genes related to prognosis of metastatic melanoma, and identified 11 key genes via survival analysis. We find that IL10RA has the highest correlation with clinically important modules among all identified biomarker genes. Further in vitro biochemical experiments, including CCK8 assays, wound-healing assays and transwell assays, have verified that IL10RA can significantly inhibit the proliferation, migration and invasion of melanoma cells. Furthermore, gene set enrichment analysis shows that PI3K-AKT signaling pathway is significantly enriched in metastatic melanoma with highly expressed IL10RA, indicating that IL10RA mediates in metastatic melanoma via PI3K-AKT pathway.

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Section: Il10ra Potentially Mediates In Metastatic Melanoma Via Pi3k-mentioning

confidence: 99%

Identification of IL10RA by Weighted Correlation Network Analysis and in vitro Validation of Its Association With Prognosis of Metastatic Melanoma

Cheng

Zhang

et al. 2021

Front. Cell Dev. Biol.

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“…Indeed, the PI3K-AKT-mTOR pathway plays a role in the regulation of monocyte-derived macrophage and Kupffer cell activity. (51,52) It has demonstrated that the PI3K-AKT-mTOR pathway is involved in the activation of macrophages and the proinflammatory cytokines produced by macrophages in CCl 4 -induced hepatobiliary injuries and fibrosis. (53) Because mTOR signaling plays a key role in cholangiocytes and immune cell function, there is increasing interest in developing therapies to inhibit the PI3K-AKT-mTOR signaling pathway to fight different types of cholangiopathies.…”

Section: Changes In Immune Cell Metabolismmentioning

confidence: 99%

Roles of Trained Immunity in the Pathogenesis of Cholangiopathies: A Therapeutic Target

Yan

Koda

et al. 2020

Hepatology

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altered production of defense cytokines and chemokines (interleukin 6 , tumor necrosis factor-α [TNF-α], IL-1β, IL-8, and so on; Fig. 1). In the trained immunity process induced by Candida albicans and β-glucan, metabolic change occurs through the AKT-mammalian target of rapamycin (mTOR)hypoxia inducible factor 1α (HIF1α) pathway. This pathway leads to epigenetic reprogramming of innate immune cells. (9) It is interesting to note that there is a direct link between metabolic changes and the aRtICle INFoRMatIoN:

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The on-off action of Forkhead protein O3a in endotoxin tolerance of Kupffer cells depends on the PI3K/AKT pathway

Cited by 2 publications

References 38 publications

Identification of IL10RA by Weighted Correlation Network Analysis and in vitro Validation of Its Association With Prognosis of Metastatic Melanoma

Identification of IL10RA by Weighted Correlation Network Analysis and in vitro Validation of Its Association With Prognosis of Metastatic Melanoma

Roles of Trained Immunity in the Pathogenesis of Cholangiopathies: A Therapeutic Target

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