The omics strategy: the use of systems vaccinology to characterize immune responses to childhood immunization

O’Connor, Daniel

doi:10.1080/14760584.2022.2093193

Cited by 7 publications

(2 citation statements)

References 102 publications

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“…One study showed that using Lactobacillus as a probiotic with vaccines improved the capacity of infants to mount immune responses against protein agents [180]. Probiotics may also have immunomodulatory effects on vaccine responses for children whose mothers had a history of allergic disease [181]. Recently, a murine study indicated that a probiotic strain of Lactobacillus plantarum improved immune response to SARS-CoV-2 vaccination [182].…”

Section: Vaccines and The Microbiomementioning

confidence: 99%

The Gut Microbiome of Children during the COVID-19 Pandemic

et al. 2022

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The gut microbiome has been shown to play a critical role in maintaining a healthy state. Dysbiosis of the gut microbiome is involved in modulating disease severity and potentially contributes to long-term outcomes in adults with COVID-19. Due to children having a significantly lower risk of severe illness and limited sample availability, much less is known about the role of the gut microbiome in children with COVID-19. It is well recognized that the developing gut microbiome of children differs from that of adults, but it is unclear if this difference contributes to the different clinical presentations and complications. In this review, we discuss the current knowledge of the gut microbiome in children with COVID-19, with gut microbiome dysbiosis being found in pediatric COVID-19 but specific taxa change often differing from those described in adults. Additionally, we discuss possible mechanisms of how the gut microbiome may mediate the presentation and complications of COVID-19 in children and the potential role for microbial therapeutics.

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Section: Vaccines and The Microbiomementioning

confidence: 99%

The Gut Microbiome of Children during the COVID-19 Pandemic

et al. 2022

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“…Nonetheless, if our work pinpoints rTcMIP as a potential efficient adjuvant for pediatric vaccines, huge work has still to be done. The mechanism of action should be further investigated with high-throughput approaches in human in vitro systems vaccinology (97)(98)(99). It should also be examined if rTcMIP would induce cross-antibodies to human FKBPs.…”

Section: Discussionmentioning

confidence: 99%

The macrophage infectivity potentiator of Trypanosoma cruzi induces innate IFN-γ and TNF-α production by human neonatal and adult blood cells through TLR2/1 and TLR4

et al. 2023

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We previously identified the recombinant (r) macrophage (M) infectivity (I) potentiator (P) of the protozoan parasite Trypanosoma cruzi (Tc) (rTcMIP) as an immuno-stimulatory protein that induces the release of IFN-γ, CCL2 and CCL3 by human cord blood cells. These cytokines and chemokines are important to direct a type 1 adaptive immune response. rTcMIP also increased the Ab response and favored the production of the Th1-related isotype IgG2a in mouse models of neonatal vaccination, indicating that rTcMIP could be used as a vaccine adjuvant to enhance T and B cell responses. In the present study, we used cord and adult blood cells, and isolated NK cells and human monocytes to investigate the pathways and to decipher the mechanism of action of the recombinant rTcMIP. We found that rTcMIP engaged TLR1/2 and TLR4 independently of CD14 and activated the MyD88, but not the TRIF, pathway to induce IFN-γ production by IL-15-primed NK cells, and TNF-α secretion by monocytes and myeloid dendritic cells. Our results also indicated that TNF-α boosted IFN-γ expression. Though cord blood cells displayed lower responses than adult cells, our results allow to consider rTcMIP as a potential pro-type 1 adjuvant that might be associated to vaccines administered in early life or later.

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Quo Vadis, pediatrics? Upcoming challenges and opportunity in child health

Valitutti,

Verrotti

2024

Global Pediatrics

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The omics strategy: the use of systems vaccinology to characterize immune responses to childhood immunization

Cited by 7 publications

References 102 publications

The Gut Microbiome of Children during the COVID-19 Pandemic

The Gut Microbiome of Children during the COVID-19 Pandemic

The macrophage infectivity potentiator of Trypanosoma cruzi induces innate IFN-γ and TNF-α production by human neonatal and adult blood cells through TLR2/1 and TLR4

Quo Vadis, pediatrics? Upcoming challenges and opportunity in child health

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