The omentum, a niche for premetastatic ovarian cancer

Ma, Xiaojing

doi:10.1084/jem.20192312

Cited by 17 publications

(14 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Soft tissue thickening, nodularity, and all are the signs of peritoneal involvement [6]. The tumor cells traverse the peritoneum through the "transcoelomic" spread with the omentum being the most common site of these metastases [7].…”

Section: Discussionmentioning

confidence: 99%

Spiderweb omentum – A previously unknown surgical finding in ovarian cancer

Ray¹,

Chhebbi²

2022

J Clin Images Med Case Rep

View full text Add to dashboard Cite

Carcinoma ovary is the most lethal gynecological malignancy and thereby, leading cause of death worldwide. Most common histopathology of ovarian cancer is high-grade serous carcinoma. More than 75% patients present at advanced stages, FIGO stage III onwards. The response of chemotherapy in patients is variable and the surgical finding of the state of omentum following chemotherapy has not been described specifically in literature. Here we presented a case of carcinoma ovary whose omental caking totally dissolved after chemotherapy leaving behind only the vasculature resembling a spiderweb. Though the treatment policy was the same. Keywords: Carcinoma ovary; Neoadjuvant Chemotherapy; Omental caking; Spiderweb omentum.

show abstract

Section: Discussionmentioning

confidence: 99%

Spiderweb omentum – A previously unknown surgical finding in ovarian cancer

Ray¹,

Chhebbi²

2022

J Clin Images Med Case Rep

View full text Add to dashboard Cite

show abstract

“…Cancer associated fibroblasts (CAFs) promote tumorigenesis through production of cytokines, growth factors, and extracellular matrix components, leading to worsening fibrosis and tumor growth [ 8 ]. Subsequent to the growth of cancer cells in the ovary, these cells are susceptible to spread within the peritoneal cavity, homing to the highly vascular, fatty tissue of the omentum that uses immunologic and metabolic mechanisms to promote tumor growth [ 9 ]. In order to understand the role of HE4/ WFDC2 in ovarian cancer, it is important to consider its known functions and how these might interplay with this complex ovarian tumor microenvironment.…”

Section: Introductionmentioning

confidence: 99%

A bioinformatic analysis of WFDC2 (HE4) expression in high grade serous ovarian cancer reveals tumor-specific changes in metabolic and extracellular matrix gene expression

et al. 2022

View full text Add to dashboard Cite

“…It is widely accepted that the omentum is involved in the immune response and fluid exchange of the human abdominal cavity [ 4 ]. In addition, it is becoming increasingly apparent that the omentum is directly involved in the development of a series of cancers, including ovarian cancer, gastric cancer, and pancreatic cancer [ 5 , 6 , 7 ]. Previous research has suggested that adipocytes provide energy for the rapid growth of ovarian cancer and enhance tumor cell metastasis [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Exosomes from Human Omental Adipose-Derived Mesenchymal Stem Cells Secreted into Ascites Promote Peritoneal Metastasis of Epithelial Ovarian Cancer

Liu

Cui

et al. 2022

Cells

View full text Add to dashboard Cite

Epithelial ovarian cancer (EOC) patients frequently develop peritoneal metastasis, especially in the human omentum. However, the mechanism underlying this propensity remains unknown. A previous study found that human omental adipose-derived mesenchymal stem cells are potentially involved in ovarian cancer growth and metastasis, but the results were inconsistent and even contradictory. In addition, the underlying mechanisms of visceral adipose metastasis remain poorly understood. Here, our goal is to clarify the role and mechanism of human omental adipose-derived mesenchymal stem cells (HO-ADSCs) in EOC cancer growth and metastasis. We first found that human omental tissue conditioned medium (HO-CM) enhances EOC cell function. Subsequent coculture studies indicated that HO-ADSCs increase the growth, migratory and invasive capabilities of ovarian cancer cells. Then, we demonstrated that exosomes secreted by HO-ADSCs (HO-ADSC exosomes) enhanced ovarian cancer cell function, and further mechanistic studies showed that the FOXM1, Cyclin F, KIF20A, and MAPK signaling pathways were involved in this process. In addition, subcutaneous tumorigenesis and peritoneal metastatic xenograft experiments provided evidence that HO-ADSC exosomes promote ovarian cancer growth and metastasis in vivo. Finally, our clinical studies provided evidence that ascites from ovarian cancer patients enhance EOC cell line proliferation, migration, and invasion in vitro. The present study indicated that HO-ADSC exosomes are secreted into ascites and exert a tumor-promoting effect on EOC growth and metastasis, providing a new perspective and method to develop future novel therapeutic strategies for the treatment of ovarian cancer.

show abstract

The omentum, a niche for premetastatic ovarian cancer

Cited by 17 publications

References 14 publications

Spiderweb omentum – A previously unknown surgical finding in ovarian cancer

Spiderweb omentum – A previously unknown surgical finding in ovarian cancer

A bioinformatic analysis of WFDC2 (HE4) expression in high grade serous ovarian cancer reveals tumor-specific changes in metabolic and extracellular matrix gene expression

Exosomes from Human Omental Adipose-Derived Mesenchymal Stem Cells Secreted into Ascites Promote Peritoneal Metastasis of Epithelial Ovarian Cancer

Contact Info

Product

Resources

About